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ANZ Journal of Surgery Jan 2022
Topics: Cytoreduction Surgical Procedures; Humans; Neurofibroma, Plexiform
PubMed: 34151490
DOI: 10.1111/ans.17018 -
Archives of Gynecology and Obstetrics Nov 2002Neurofibromatosis is a genetic disease that affects multiple organ systems, and has a wide range of clinical features. Neurofibromatosis in pregnancy is encountered with...
Neurofibromatosis is a genetic disease that affects multiple organ systems, and has a wide range of clinical features. Neurofibromatosis in pregnancy is encountered with a frequency of 1:2434 to 1:18,500 deliveries. Plexiform neurofibromas are rare subcutaneous nodules or amorphous overgrowth of subcutaneous tissues, which may affect the underlying bone, and produce deformities. We present a patient with a giant plexiform neurofibroma of the thigh which got larger in pregnancy, and shrunk a bit in the postpartum period.
Topics: Adult; Diagnosis, Differential; Female; Humans; Neurofibroma, Plexiform; Pregnancy; Pregnancy Complications, Neoplastic; Prenatal Care; Skin Neoplasms; Thigh
PubMed: 12410373
DOI: 10.1007/s004040100239 -
International Journal of Pediatric... May 2008Primary neurogenic tumours of facial nerve are uncommon with the majority found intra-temporally. Intracranial and intra-parotid neoplastic involvement of cranial nerve... (Review)
Review
INTRODUCTION
Primary neurogenic tumours of facial nerve are uncommon with the majority found intra-temporally. Intracranial and intra-parotid neoplastic involvement of cranial nerve VII is much less common. There are 11 reported cases, in the English-language literature, of intra-parotid facial nerve plexiform neurofibromas with eight of them associated with NF1.
MATERIALS AND METHODS
A child, 10 years old, with NF1, reached us for a cheek swelling, slowly increased in previous 8 years. At the age of 3 years, a plexiform neurofibroma was diagnosed by biopsy of the lesion. Clinical examination and NMR showed in the sub-cutaneous tissue of the right cheek, two contiguous nodular lesions, about 2 cm x 1.5 cm in diameter; a third neoformed lesion, about 1cm in diameter, was located above the ipsilateral labial commissure. No facial nerve impairment was seen. The patient underwent superficial parotidectomy with removal of the lesions and preservation of the facial nerve.
RESULTS
The patient had a considerable regional swelling in the immediate post-operative course; no facial nerve impairment was observed. The swelling of the cheek did not show a fully regression in the post-operative course. Ultrasonography at 3 months showed a recurrence of disease.
DISCUSSION
Plexiform neurofibromas should be distinguished due to their risk of malignant transformation seen in up to 15% of patients affected by NF1. Surgery is the only effective option currently available for the treatment of PNF. However, success of surgical intervention is limited by the infiltrating nature of the tumours, resulting in a high rate of tumour re-growth. Facial nerve preservation during surgery is unlikely and significant morbidity can result from their excision. The age of the patient at surgical resection seemed to influence outcome: tumours resected before age 10 years recurred in 60% of cases compared with only 30% recurrence in patients older than the age of 10 years.
CONCLUSION
Indication and timing of surgery, in paediatrics patients with NF1, are complex. To avoid eventual physical and psychological consequences, it seems prudent to delay surgery as long as it is feasible for otherwise asymptomatic paediatric patients with facial plexiform neurofibroma.
Topics: Child; Humans; Male; Neurofibroma, Plexiform; Neurofibromatosis 1; Parotid Neoplasms
PubMed: 18329107
DOI: 10.1016/j.ijporl.2008.01.022 -
Plastic and Reconstructive Surgery Aug 2021
Topics: Adult; Blood Loss, Surgical; Electrocoagulation; Female; Hemostasis, Surgical; Humans; Length of Stay; Male; Middle Aged; Neurofibroma, Plexiform; Neurofibromatosis 1; Operative Time; Treatment Outcome; Tumor Burden
PubMed: 34254965
DOI: 10.1097/PRS.0000000000008163 -
Urology Feb 1997We report extensive genitourinary neurofibroma in two children who presented with massive bilateral hydroureteronephrosis and a thick-walled bladder. The best radiologic... (Review)
Review
We report extensive genitourinary neurofibroma in two children who presented with massive bilateral hydroureteronephrosis and a thick-walled bladder. The best radiologic technique to stage the disease and determine treatment is magnetic resonance imaging. Management of extensive genitourinary neurofibroma is controversial. Based upon our experience and a review of the literature, aggressive surgery should be approached cautiously.
Topics: Humans; Infant; Male; Neurofibroma, Plexiform; Urogenital Neoplasms
PubMed: 9037291
DOI: 10.1016/S0090-4295(96)00354-8 -
British Journal of Neurosurgery Jun 2019We reported a rare peripheral nerve case, a patient developed carpal tunnel syndrome with a history of floating thumb in right hand. The median nerve was found expanded...
We reported a rare peripheral nerve case, a patient developed carpal tunnel syndrome with a history of floating thumb in right hand. The median nerve was found expanded and spindle-shaped and a plexiform neurofibroma was diagnosed. Our case sheds light on anatomy and possible etiological association which may help clinical management.
Topics: Adult; Carpal Tunnel Syndrome; Electrodiagnosis; Female; Humans; Magnetic Resonance Imaging; Median Nerve; Neurofibroma, Plexiform; Peripheral Nervous System Neoplasms; Thumb; Treatment Outcome
PubMed: 28554231
DOI: 10.1080/02688697.2017.1333572 -
Oral Oncology Jun 2011Plexiform neurofibroma (PN) is a rare, benign tumor of nerve sheath origin, which frequently manifests as part of neurofibromatosis type 1. The article presents a case... (Review)
Review
Plexiform neurofibroma (PN) is a rare, benign tumor of nerve sheath origin, which frequently manifests as part of neurofibromatosis type 1. The article presents a case of solitary PN in a 4-year-old girl, which manifested as a double lip and without systemic or familial involvement. A review of the literature on solitary PN in the oral soft tissue demonstrates the scarcity of such cases.
Topics: Child, Preschool; Female; Humans; Lip Neoplasms; Neurofibroma, Plexiform; Neurofibromatosis 1
PubMed: 21571578
DOI: 10.1016/j.oraloncology.2011.04.005 -
Journal of Cutaneous Pathology Jun 2010
Review
Topics: Humans; Neurofibroma, Plexiform; Skin Neoplasms
PubMed: 20175825
DOI: 10.1111/j.1600-0560.2010.01529.x -
Head & Neck Mar 1997Plexiform neurofibromatosis is a feature of von Recklinghausen's disease. Head and neck lesions may produce varying degrees of cosmetic and functional deformity.... (Review)
Review
BACKGROUND
Plexiform neurofibromatosis is a feature of von Recklinghausen's disease. Head and neck lesions may produce varying degrees of cosmetic and functional deformity. However, life-threatening hemorrhage into facial plexiform neurofibromas has not been previously reported.
METHOD
We report two patients with von Recklinghausen's disease who experienced massive hemorrhage into facial neurofibromas, one following a blunt injury and the other without a known initiating event.
RESULTS
Conservative management did not stop the hemorrhage into facial neurofibromas in either instance. Surgical exploration was mandated for hemorrhage control and evacuation of blood clots. Hemostasis was attained by a combination of hypotensive anesthesia and chromic catgut suture ligatures.
CONCLUSIONS
These case reports demonstrate a potentially lethal complication in patients with facial plexiform neurofibroma. Where a competent and experienced interventional neuroradiologist is not available, surgical exploration should be undertaken to control bleeding.
Topics: Adolescent; Adult; Facial Bones; Facial Neoplasms; Hemorrhage; Humans; Male; Neurofibroma, Plexiform; Neurofibromatosis 1
PubMed: 9059876
DOI: 10.1002/(sici)1097-0347(199703)19:2<158::aid-hed13>3.0.co;2-9 -
Journal of Plastic, Reconstructive &... Nov 2008
Topics: Adult; Fingers; Humans; Male; Neurofibroma, Plexiform; Neurofibromatosis 1
PubMed: 18722169
DOI: 10.1016/j.bjps.2008.02.038