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Proceedings of the Society For... Jun 1951
Topics: Humans; Podophyllin
PubMed: 14854016
DOI: 10.3181/00379727-77-18746 -
Journal of the American Academy of... Mar 1984
Topics: Humans; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Resins, Plant
PubMed: 6725662
DOI: 10.1016/s0190-9622(84)80106-1 -
Indian Pediatrics Jun 2002
Topics: Accidents, Home; Child, Preschool; Female; Follow-Up Studies; Humans; Podophyllin; Risk Assessment
PubMed: 12084961
DOI: No ID Found -
Genitourinary Medicine Jun 1997To compare the effectiveness and cost of self treatment of penile warts with a commercial preparation of podophyllotoxin 0.5% (PDX 0.5%) with podophyllin 0.5% and... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
OBJECTIVE
To compare the effectiveness and cost of self treatment of penile warts with a commercial preparation of podophyllotoxin 0.5% (PDX 0.5%) with podophyllin 0.5% and podophyllin 2.0% sourced from Podophyllum emodii.
DESIGN
A prospective double blind randomised study.
SUBJECTS
315 patients with penile warts attending two departments of genitourinary medicine.
MAIN OUTCOME MEASURES
Absence of warts, cessation of treatment due to severe side effects at 5 weeks.
RESULTS
Of the 315 patients, 244 conformed to the protocol. Analysis was on an intention to treat basis. At 5 weeks no significant differences were found in the extent of healing of warts or in side effects for the three treatment groups. The costs of drug treatment (excluding staff time) are at least pounds 10.00 less for podophyllin than podophyllotoxin. A fourfold variation in the active constituents of the podophyllin preparations did not produce appreciably different clinical responses. In a subanalysis no evidence of deterioration in effectiveness of podophyllin over time was demonstrated.
CONCLUSIONS
Penile warts in selected cases can be safely treated with 0.5-2.0% podophyllin self applied by the patient at a fraction of the cost of commercially available podophyllotoxin. The shelf life of the podophyllin extracts is at least 3 months. These findings may be especially relevant in countries where resources for health care are limited.
Topics: Condylomata Acuminata; Double-Blind Method; Drug Stability; Humans; Keratolytic Agents; Male; Penile Diseases; Podophyllin; Podophyllotoxin; Prospective Studies; Self Administration
PubMed: 9306898
DOI: 10.1136/sti.73.3.184 -
Ugeskrift For Laeger Dec 1959
Topics: Humans; Podophyllin; Podophyllum
PubMed: 13792145
DOI: No ID Found -
International Journal of STD & AIDS Aug 2023Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial. (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial.
AIM
To evaluate the effectiveness and safety of diphenylcyclopropenone and podophyllin in treating genital warts.
METHODS
This study included 57 patients, divided randomly into two groups. Group (A): diphenylcyclopropenone ( = 29). Group (B): podophyllin 25% ( = 28). In group (A), sensitization was done with 2% diphenylcyclopropenone. Then, after 1 or 2 weeks, treatment started with a weekly application of diphenylcyclopropenone solutions ranging between 0.001 and 1% until clearance, or for a maximum of 10 sessions. In group (B), podophyllin 25% was applied weekly until clearance or for a maximum of 6 weeks.
RESULTS
Higher clearance was achieved in group A, with 19 of 29 (65.5%) patients, than in group B, with 9 of 28 (32.1%) (-value = 0.004). Also, effectiveness increases with young age in group A. Shorter wart duration was associated with better response in both groups (-value = 0.005). No serious adverse effects occurred in either group. No recurrence was detected in group A, while seven patients (77.8%) had recurrence in group B after 1 year of follow up.
CONCLUSION
Diphenylcyclopropenone shows a higher success rate than podophyllin in treating genital warts and a lower recurrence rate.
Topics: Humans; Condylomata Acuminata; Cyclopropanes; Podophyllin; Warts
PubMed: 37018551
DOI: 10.1177/09564624231169330 -
The Journal of Investigative Dermatology Jul 1951
Topics: Acanthosis Nigricans; Humans; Podophyllin
PubMed: 14850774
DOI: 10.1038/jid.1951.55 -
Science (New York, N.Y.) Apr 1947
Topics: Cell Physiological Phenomena; Humans; Podophyllin
PubMed: 17752486
DOI: 10.1126/science.105.2730.433 -
The British Journal of Venereal Diseases Jun 1981One hundred and forty male patients with ano-genital warts were randomly allocated to a double-blind study of 10% and 25% podophyllin in tincture of benzoin compound.... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
One hundred and forty male patients with ano-genital warts were randomly allocated to a double-blind study of 10% and 25% podophyllin in tincture of benzoin compound. One hundred and nine patients attended for a three-month period of surveillance. Only 24 (22%) patients were free of warts after having podophyllin treatment alone, 12 each after treatment with 10% and 25% podophyllin. There was no significant difference in the number of applications needed with each treatment. Neither hypersensitivity nor chemical ulceration occurred.
Topics: Anus Diseases; Clinical Trials as Topic; Double-Blind Method; Genital Diseases, Male; Humans; Male; Podophyllin; Random Allocation; Warts
PubMed: 7016248
DOI: 10.1136/sti.57.3.208 -
Drug and Chemical Toxicology 2009The genotoxic potential of podophyllin (PD) was investigated in this study. PD increased bacterial revertants and abnormal chromosomal structures in a...
The genotoxic potential of podophyllin (PD) was investigated in this study. PD increased bacterial revertants and abnormal chromosomal structures in a concentration-dependent manner, both with and without metabolic activating enzymes, and increased the incidence of micronuclei in imprinted control region mouse reticulocytes. Results from three studied constituents of PD, such as podophyllotoxin, kampferol, and quercetin, suggested that the mutagenic effect of PD was not due to the presence of podophyllotoxin, kampferol, and quercetin and might be related to other components and the formation of reactive oxygen species. The detailed mutagenic mechanisms need further investigation, and the medicinal use of PD needs to be cautioned against.
Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Kaempferols; Male; Mice; Mice, Inbred ICR; Micronuclei, Chromosome-Defective; Mutagenicity Tests; Mutagens; Podophyllin; Podophyllotoxin; Quercetin; Rats; Rats, Wistar; Reactive Oxygen Species; Reticulocytes
PubMed: 19514941
DOI: 10.1080/01480540802433757