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American Journal of Ophthalmology Nov 1946
Topics: Humans; Podophyllin
PubMed: 20276981
DOI: 10.1016/0002-9394(46)92042-9 -
Southern Medical Journal Oct 1982
Topics: Adult; Humans; Male; Podophyllin
PubMed: 7123303
DOI: 10.1097/00007611-198210000-00031 -
Lekarske Listy Feb 1951
Topics: Dermatology; Humans; Podophyllin
PubMed: 14805239
DOI: No ID Found -
Dermatologica 1948
Topics: Podophyllin; Podophyllum
PubMed: 18100128
DOI: No ID Found -
Genitourinary Medicine Apr 1995Topical application of podophyllin is a routine procedure in patients with ano-genital warts. Podophyllin is a crude plant extract and is therefore not a well-defined...
INTRODUCTION
Topical application of podophyllin is a routine procedure in patients with ano-genital warts. Podophyllin is a crude plant extract and is therefore not a well-defined product. It may contain variable amounts of the active lignan podophyllotoxin and the majority of the dry weight of podophyllin is made up of substances never identified.
OBJECTIVE
The purpose of the study was to estimate in podophyllin 20% the amounts of two mutagenic substances, quercetin and kaempherol.
METHODS
Using high-pressure liquid chromatography the amounts of quercetin and kaempherol were determined in 3 batches of podophyllin 20%.
RESULTS
Quercetin and kaempherol constitutes 2.5-3.8% and 6.0-6.4% of podophyllin dry substance, respectively. Podophyllotoxin constitutes in comparison 12.7-13.8% of podophyllin dry substance.
CONCLUSION
As approximately 10% of the amount of dry substance in podophyllin 20% is composed of two mutagenic flavonoids, quercetin and kaempherol, efforts should be focused on the production of a well-defined purified podophyllotoxin preparation that may replace podophyllin for clinic use in patients with genital warts. Self-medication with purified podophyllotoxin 0.5% may be considered as first-line treatment in well-instructed patients with external genital warts.
Topics: Chromatography, High Pressure Liquid; Condylomata Acuminata; Contraindications; Flavonoids; Mutagens; Podophyllin; Quercetin
PubMed: 7744421
DOI: 10.1136/sti.71.2.92 -
Archives of Dermatology Nov 1988
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, General; Condylomata Acuminata; Female; Humans; Podophyllin; Pregnancy; Pregnancy Complications, Neoplastic
PubMed: 3178255
DOI: No ID Found -
Clinical and Experimental Dermatology Jul 2008A 40-year-old woman presented with a delusion of warts on the forehead, for which she was applying podophyllin toxin. A skin biopsy was taken, which showed prominent...
A 40-year-old woman presented with a delusion of warts on the forehead, for which she was applying podophyllin toxin. A skin biopsy was taken, which showed prominent mitotic figures in the basal and suprabasal layers of the epidermis and apoptotic keratinocytes. Histopathologically Bowen's disease was suspected, but was discounted after clinicopathological correlation was obtained and showed absence of epidermal atypia or disorganization. This case demonstrates the histological resemblance of podophyllin reaction to Bowen's disease. Differentiation of self-inflicted from organic skin disease may be difficult, especially where histopathological findings are confounded by cutaneous application of toxins.
Topics: Adult; Bowen's Disease; Caustics; Delusions; Diagnosis, Differential; Female; Humans; Parakeratosis; Podophyllin; Scalp Dermatoses; Self Medication; Skin Neoplasms; Warts
PubMed: 18261136
DOI: 10.1111/j.1365-2230.2007.02668.x -
Journal of the American Academy of... Feb 1984
Comparative Study
Topics: Humans; Pharmacopoeias as Topic; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Resins, Plant; United States
PubMed: 6715606
DOI: 10.1016/s0190-9622(84)80238-8 -
Human & Experimental Toxicology Jan 1990Podophyllin is available without prescription and is commonly used in the topical treatment of warts. We describe a case of accidental ingestion of podophyllin, mistaken...
Podophyllin is available without prescription and is commonly used in the topical treatment of warts. We describe a case of accidental ingestion of podophyllin, mistaken for cough linctus, and its resultant toxicity.
Topics: Humans; Male; Middle Aged; Podophyllin
PubMed: 2328153
DOI: 10.1177/096032719000900113 -
Sexually Transmitted Diseases May 2020Anogenital warts (AGWs) are a common therapeutic challenge. All therapies are associated with burning, pain, and frustrating high rate of recurrence. The search for a... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Anogenital warts (AGWs) are a common therapeutic challenge. All therapies are associated with burning, pain, and frustrating high rate of recurrence. The search for a new alternative continues. Recently, a diterpene ester extracted from the Euphorbia peplus plant (ingenol mebutate [IM]) has been shown to possess activity against AGWs.
OBJECTIVE
This study aimed to compare and evaluate the therapeutic efficacy and safety of topical 0.05% ingenol gel with another herbal extract medication (topical 25% podophyllin solution) in treatment of AGWs.
METHODS
This was a comparative single blinded nonrandomized, 2-arm trial of ingenol 0.05% gel versus podophyllin solution 25% administered up to 6 times to patients with AGWs. To evaluate the therapeutic efficacy, the complete clearance rate and recurrence rate were assessed 1 and 12 weeks after last treatment, respectively. Safety was assessed by occurrence and severity of pain and local skin reaction (LSR).
RESULTS
Of 31 and 36 patients in the IM group and podophyllin group who completed the study, initial complete resolution was observed in 20 (64.5%) and 14 (38.9%) patients, respectively (P = 0.03). The initial clearance was faster in the IM group (2.00 ± 0.91 weeks) compared with the podophyllin group (4.21 ± 1.05 weeks, P = 0.00). After 3 months, recurrence was seen in 13 (65.0%) of 20 patients in the IM group and 6 (42.8%) of 14 in the podophyllin group (P = 0.20). The number of patients with complete resolution after 3 months was not different between the 2 groups (7/31 in the IM group and 8/36 in the podophyllin group, P = 0.97). The mean ± SD severity scores for LSR and pain in the IM group were 6.65 ± 1.76 and 6.13 ± 2.57, respectively, which was significantly higher than their scores (3.39 ± 1.57 and 2.58 ± 1.38) in the podophyllin group (P = 0.00).
CONCLUSION
Ingenol mebutate 0.05% gel is effective as podophyllin 25% solution in treating AGWs, with further benefit of being much more rapid. However, high recurrence rate, sever pain, and LSR limit its use.
Topics: Adult; Anus Diseases; Condylomata Acuminata; Diterpenes; Female; Gels; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Podophyllin; Prospective Studies; Treatment Outcome
PubMed: 32149954
DOI: 10.1097/OLQ.0000000000001165