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Revue Neurologique 1991A 53 year-old veterinary surgeon accidentally ingested 0.8 g of podophyllin. Twelve hours later, he was deeply comatose, with clinical and EMG signs of extensive axonal... (Review)
Review
A 53 year-old veterinary surgeon accidentally ingested 0.8 g of podophyllin. Twelve hours later, he was deeply comatose, with clinical and EMG signs of extensive axonal sensorimotor and autonomic peripheral neuropathy. In addition, transient bone marrow and hepatic toxicity occurred. The coma lasted 2 weeks. Systemic and neurological disturbances started to improve at 3 months post-onset, but the patient died four months later from gastro-intestinal bleeding. Sural nerve biopsy showed loss of myelinated fibers and signs of axonal degeneration with type E teased fibers. The cytoplasm of Schwann and endothelial cells was vacuolated and swelled. Diffuse interstitial aedema was noted. Podophyllin acts as a spindle poison, binds microtubular proteins and inhibits axoplasmic flow.
Topics: Accidents; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Podophyllin; Sural Nerve
PubMed: 1648254
DOI: No ID Found -
Obstetrics and Gynecology Jul 1978The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as...
The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as hematologic and hepatic toxicity was observed. Therapy with a new modality, charcoal hemoperfusion, resulted in resolution of the acute toxicity, leaving a peripheral neuropathy which had not completely resolved after 4 months. The pharmacology and suggested treatment measures for the toxicity of this rarely reported agent are reviewed.
Topics: Administration, Topical; Adolescent; Charcoal; Chemical Phenomena; Chemistry; Condylomata Acuminata; Female; Hemoperfusion; Humans; Podophyllin; Podophyllotoxin; Skin; Vulvar Neoplasms
PubMed: 683634
DOI: No ID Found -
American Journal of Obstetrics and... Apr 1947
Topics: Female; Humans; Male; Neoplasms; Papilloma; Podophyllin; Skin Neoplasms; Urethra; Vulva
PubMed: 20291237
DOI: 10.1016/0002-9378(47)90285-8 -
The Journal of Organic Chemistry Dec 1966
Topics: Chemical Phenomena; Chemistry; Chemistry, Organic; Organic Chemistry Phenomena; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Sodium
PubMed: 5978075
DOI: 10.1021/jo01350a028 -
British Medical Journal Sep 1972
Topics: Female; Genital Diseases, Female; Humans; Podophyllin; Pregnancy; Pregnancy Complications, Infectious; Vulva; Warts
PubMed: 4650855
DOI: No ID Found -
The Urologic and Cutaneous Review Jul 1949
Topics: Condylomata Acuminata; Humans; Podophyllin
PubMed: 18149907
DOI: No ID Found -
The Urologic and Cutaneous Review Apr 1947
Topics: Humans; Mental Disorders; Podophyllin; Substance-Related Disorders
PubMed: 20249395
DOI: No ID Found -
Archives of Dermatology Apr 1966
Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Humans; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Salicylates
PubMed: 5862640
DOI: No ID Found -
Genitourinary Medicine Aug 1988The increasing incidence of genital warts has led to more public awareness of this infection and its possible sequelae. Currently available treatment remains... (Comparative Study)
Comparative Study
The increasing incidence of genital warts has led to more public awareness of this infection and its possible sequelae. Currently available treatment remains unsatisfactory, and there is pressure to develop effective and convenient alternatives. Podophyllotoxin is standardised and stable, whereas podophyllin has a variable composition. In an open comparison of self applied podophyllotoxin 0.5% versus podophyllin 20% applied by a doctor to treat external penile warts, podophyllotoxin was more effective and gave quicker resolution than podophyllin. Side effects were similar for both preparations, and few patients experienced complications severe enough to stop treatment. Podophyllotoxin can therefore be used safely and effectively for home treatment monitored at an outpatient clinic and provides a useful alternative to treatment with podophyllin at overburdened genitourinary medicine clinics.
Topics: Adult; Condylomata Acuminata; Humans; Male; Middle Aged; Penile Neoplasms; Podophyllin; Podophyllotoxin; Self Administration
PubMed: 3169757
DOI: 10.1136/sti.64.4.263 -
The Journal of Infectious Diseases Jul 1990To determine the value of combining interferon with standard local therapy in the treatment of human papillomavirus infection, 97 patients with anogenital warts were... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
To determine the value of combining interferon with standard local therapy in the treatment of human papillomavirus infection, 97 patients with anogenital warts were randomized to a short course of either interferon plus podophyllin or podophyllin alone. Interferon alpha 2b (1.5 x 10(6) IU) was injected intralesionally and podophyllin resin applied topically to each of three warts once weekly for 3 weeks. Maximal responses occurred within 2 weeks of therapy, and overall there was complete clearance of treated warts in 67% of interferon and podophyllin versus 42% of podophyllin recipients (P less than .05, chi 2). Clearance rates were greater in women, patients with warts of less than or equal to 12 months' duration, and HIV-seronegative patients. Of patients with complete clearance, 67% of interferon and podophyllin and 65% of podophyllin recipients experienced recurrences. Thus, in short treatment courses of anogenital warts, intralesional interferon enhanced the effect of topical podophyllin, and trials of combination therapy using more intensive or prolonged regimens of interferon are warranted.
Topics: Administration, Topical; Adolescent; Adult; Analysis of Variance; Combined Modality Therapy; Condylomata Acuminata; Female; Follow-Up Studies; HIV Seropositivity; Humans; Injections, Intralesional; Interferon Type I; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Podophyllin; Recombinant Proteins; Recurrence
PubMed: 2192011
DOI: 10.1093/infdis/162.1.52