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Archives of Dermatology and Syphilology Jul 1949
Topics: Podophyllin; Podophyllotoxin
PubMed: 18152062
DOI: 10.1001/archderm.1949.01530010004001 -
Deutsche Medizinische Wochenschrift... Jul 2002A 57-year-old depressive and alcohol-dependent man was admitted because of frequent nausea and vomiting and abdominal complaints after he had ingested 40 ml of a...
HISTORY AND ADMISSION FINDINGS
A 57-year-old depressive and alcohol-dependent man was admitted because of frequent nausea and vomiting and abdominal complaints after he had ingested 40 ml of a tincture for treating warts. He was under the influence of alcohol, but normally oriented and without contributory findings other than his gastrointestinal complaints and tachypnea.
INVESTIGATIONS
Transaminases were raised (GOT 1197 U/l, GPT 170 U/l, gammaGT 150 U/l, LDH 2047 U/l), as were creatine phosphokinase (426 U/l) and ferritin (12 200 ng/ml). Platelet count was 36000 mm3, Leucocytes count 11 700/mm (3). Gastroscopy showed marked mucosal necrosis along the entire esophagus and the pulled-up small intestine (state after gastrectomy).
DIAGNOSIS, TREATMENT AND COURSE
The patient became comatose within 5 hours, acidotic, oliguric, required ventilation and went into severe shock. The symptoms and the fact that podophyllin (pod.) was the main agent in the wart preparation confirmed the suspicion of pod. poisoning. Symptomatic and intensive care measures stabilized his critically grave condition. He was extubated on the 7th day after ingestion and on the 10th day was discharged at his own request in a relatively good general state. When he was re-admitted after 4 weeks he was without psychiatric symptoms but deeply depressed, and he had signs of a polyneuropathy in all limbs, typical of pod. toxin poisoning.
CONCLUSION
Pod. toxin, a spindle poison, is the toxic agent of pod., the resin from the roots and rhizomes of various Berberis plants. While the potential toxicity of the resin, taken either orally or applied externally, has been long known, the poorly definied raw product is still being added to anti-wart tinctures.
Topics: Administration, Oral; Alcoholism; Coma; Depression; Esophagus; Hospitalization; Humans; Keratolytic Agents; Male; Middle Aged; Platelet Count; Podophyllin; Podophyllotoxin; Polyneuropathies; Warts
PubMed: 12111657
DOI: 10.1055/s-2002-32755 -
British Medical Journal Aug 1954
Topics: Anal Canal; Anus Diseases; Condylomata Acuminata; Disease; Genitalia; Humans; Podophyllin; Warts
PubMed: 13182229
DOI: 10.1136/bmj.2.4884.397 -
International Journal of Dermatology Sep 1983Keratoacanthoma can be treated successfully with podophyllin, which has been used in cutaneous tumors for well over a century and has been in use for a much longer time....
Keratoacanthoma can be treated successfully with podophyllin, which has been used in cutaneous tumors for well over a century and has been in use for a much longer time. Podophyllin is useful alone, with cautery and curettage, or with radiotherapy.
Topics: Adult; Aged; Combined Modality Therapy; Facial Dermatoses; Female; Humans; Keratoacanthoma; Male; Middle Aged; Podophyllin; Wound Healing
PubMed: 6629612
DOI: 10.1111/j.1365-4362.1983.tb02168.x -
A.M.A. Archives of Dermatology and... Apr 1952
Topics: Animals; Foot Diseases; Humans; Podophyllin; Thoracica; Warts
PubMed: 14902122
DOI: 10.1001/archderm.1952.01530230114017 -
Acta Dermato-venereologica 1952
Topics: Humans; Neoplasms; Podophyllin; Skin Neoplasms
PubMed: 14932669
DOI: No ID Found -
La Semana Medica Feb 1946
Topics: Condylomata Acuminata; Humans; Podophyllin
PubMed: 21019658
DOI: No ID Found -
Wiener Klinische Wochenschrift Dec 1981Condylomata acuminata are benign epitheliomas which are caused by the human papilloma virus. 8 subgroups (variants) of the virus are known up to now. Condylomata... (Review)
Review
Condylomata acuminata are benign epitheliomas which are caused by the human papilloma virus. 8 subgroups (variants) of the virus are known up to now. Condylomata acuminata are infectious, the virus being transferred by direct contact with a lesion. Condylomata acuminata are found more often in males than in females and never occur in children prior to the age of two years. The peak incidence is between 19 and 22 years of age. Greatly proliferating condylomata acuminata (type Buschke-Löwenstein) may lead to malignant degeneration. There exists a broad spectrum of topical therapeutic modalities: cytotoxic substances such as podophyllin (10 to 25%), colchicine (8%), 5-fluorouracil (1 to 5%), cryotherapy (solid carbon dioxyde or liquid nitrogen), surgical treatment (excochleation, electrocautery or laser beam. Vaccination therapy may prove successful in certain cases in the future.
Topics: Adult; Cell Transformation, Neoplastic; Colchicine; Condylomata Acuminata; Cryosurgery; Electrocoagulation; Female; Fluorouracil; Humans; Laser Therapy; Male; Papillomaviridae; Podophyllin; Viral Vaccines
PubMed: 6281993
DOI: No ID Found -
Journal of the National Cancer Institute Jun 1950
Topics: Animals; Humans; Neoplasms; Podophyllin; Podophyllotoxin; Quercetin; Sarcoma 37
PubMed: 14774701
DOI: No ID Found -
The Anatomical Record Aug 1948
Topics: Animals; Planarians; Podophyllin; Podophyllum; Regeneration
PubMed: 18932963
DOI: No ID Found