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Proceedings of the Royal Society of... Mar 1932
PubMed: 19988622
DOI: No ID Found -
Journal of the European Academy of... Jul 2005Although a common dermatosis, idiopathic poikiloderma of the face and neck has not been studied in depth for decades.
BACKGROUND
Although a common dermatosis, idiopathic poikiloderma of the face and neck has not been studied in depth for decades.
OBJECTIVES
To reassess the clinical and epidemiological characteristics of poikiloderma of Civatte (PC).
MATERIAL AND METHODS
Fifty consecutive patients with PC. Evaluation included history taking and physical examination. Epidemiological and clinical parameters were recorded and analysed. The literature from 1923 until today, was reviewed thoroughly.
RESULTS
The frequency of PC among dermatologic patients was estimated to be 1.4%. There were 34 females (68%) and 16 males in the present study. The mean age at diagnosis was 47.8 years for females and 61.7 years for males. The majority (88%) had skin phototype II or III. Among females, 26 were at their peri-menopausal stage, including three cases of iatrogenic menopause. Four patients reported that other blood-related family members also had PC. The v and the sides of the neck and the upper chest were most often affected in a symmetric distribution. The face (preauricular and parotid region) was involved in 19 patients (38%). The erythemato-telangiectatic clinical type predominated (58%), followed by the mixed (22%) and the pigmented type (20%). Almost half of the patients (46%) were symptomatic (itching, burning and 'flushing'). The mean duration from onset to diagnosis was 6.2 years according to the patients' report. The course was usually slowly progressive (82%) and irreversible.
CONCLUSIONS
PC shows characteristic features, supporting the theory that it represents a distinct entity. It is rather common in Greece. Although menopausal women predominated in our cohort, men were not uncommonly affected and were diagnosed at an older age. Based on the predominating clinical feature, PC can be classified into three clinical forms. Symmetry and sparing of the anatomically shaded areas of the neck are highly characteristic for PC. Face involvement was not as common and as severe as it had been considered in the past. Recognition of clinical type is important for the selection of the most appropriate treatment, which, despite the advent of novel modalities, remains problematic.
Topics: Adult; Age Distribution; Aged; Facial Dermatoses; Female; Greece; Humans; Male; Middle Aged; Photosensitivity Disorders; Sex Distribution; Telangiectasis
PubMed: 15987290
DOI: 10.1111/j.1468-3083.2005.01213.x -
Dermatology (Basel, Switzerland) 2007Poikiloderma of the face and neck (Civatte) has not been studied in depth for decades, especially as far as the histopathology is concerned.
BACKGROUND
Poikiloderma of the face and neck (Civatte) has not been studied in depth for decades, especially as far as the histopathology is concerned.
MATERIAL AND METHODS
We studied 50 consecutive patients with poikiloderma of Civatte (PC). Their evaluation included: history, physical examination, lesional skin biopsy and histological examination of sections stained with hematoxylin-eosin, PAS, Fontana-Masson, acid orcein Giemsa for elastic fibers and toluidine blue for mast cells. In 10 randomly selected subjects, a second skin biopsy was performed and specimens were examined under the electron microscope.
RESULTS
There were 34 females (68%) and 16 males. The mean age at diagnosis was 47.8 years for females and 61.7 years for males. Histological examination revealed an atrophic (62%), flattened (84%) epidermis with hyperkeratosis (92%) and occasional follicular plugging (34%). In some cases, mild hydropic degeneration of the basal cell layer was evident (46%). Melanin was irregularly distributed in the lower epidermis (94%), and melanophages were often present in the dermis (92%). The most prominent and constant feature (100%) was solar elastosis of the papillary dermis. The blood vessels were almost invariably dilated (96%) with a mild perivascular lymphohistiocytic infiltrate (78%), sometimes with plasmacytes (56%). At the ultrastructural level, the epidermis showed only minor changes. The dermoepidermal junction was intact. The most constant findings were swelling and disruption of the collagen fibers as well as focal degeneration of the collagen bundles. Occasionally, several vacuolar spaces were found just under the basal lamina. Melanin-laden macrophages scattered in the dermis were also detected.
CONCLUSIONS
PC shows distinct histological and ultrastructural features, supporting the theory that it represents a separate entity. The histology of PC is characteristic but not pathognomonic. On this basis, the differential diagnosis from Riehl's melanosis, poikiloderma atrophicans et vasculare and other acquired poikilodermas can be made. Ultrastructural findings were consistent with the histological findings. Changes of the dermal connective tissue (solar elastosis) predominated, providing morphological evidence for the role of ultraviolet radiation in the pathogenesis of PC.
Topics: Adult; Aged; Collagen; Diagnosis, Differential; Female; Humans; Hyperpigmentation; Macrophages; Male; Middle Aged; Skin; Skin Diseases; Telangiectasis; Ultraviolet Rays; Vacuoles
PubMed: 17341870
DOI: 10.1159/000098580 -
European Journal of Dermatology : EJD Jun 2016
Topics: Aged; Dermoscopy; Diagnosis, Differential; Female; Humans; Middle Aged; Parapsoriasis
PubMed: 27018371
DOI: 10.1684/ejd.2016.2738 -
Proceedings of the Royal Society of... Apr 1952
Topics: Parapsoriasis; Skin Diseases
PubMed: 14930035
DOI: No ID Found -
Proceedings of the Royal Society of... Nov 1949
Topics: Atrophy; Connective Tissue Diseases; Humans; Rothmund-Thomson Syndrome; Skin Diseases
PubMed: 15394811
DOI: No ID Found -
The British Journal of Dermatology Mar 1964
Topics: Carcinoma; Carcinoma, Squamous Cell; Geriatrics; Lymphocytosis; Melena; Pathology; Pigmentation Disorders; Radiotherapy; Skin Diseases
PubMed: 14128263
DOI: No ID Found -
American Journal of Medical Genetics.... Oct 2014Poikiloderma with neutropenia (PN), is a rare genodermatosis associated with patognomic features of poikiloderma and permanent neutropenia. Three common recurrent...
Poikiloderma with neutropenia (PN), is a rare genodermatosis associated with patognomic features of poikiloderma and permanent neutropenia. Three common recurrent mutations of related gene, USB1, were considered to be associated with three different ethnic origins. The most common recurrent mutation, c.531delA, has been detected in seven Caucasian patients in the literature. In this paper, we present review of all patients from the literature and report two additional patients of Turkish ancestry with the diagnosis of PN. The diagnosis of these two PN patients were made clinically and confirmed by molecular analysis which detected the most common recurrent mutation, c.531delA. Genotype-ethnic origin correlation hypothesis, therefore, has been strengthened with this result. Short stature in PN, is a common finding, which until now has never been treated with growth hormone (GH). One of our patients is the first patient with attempted treatment of short stature via GH administration. Finally, both of our patients had high-pitched voice and vocal cord nodules which might be considered as additional clinical findings not associated with PN before.
Topics: Adult; Female; Genotype; Humans; Male; Mutation; Neutropenia; Phenotype; Skin Abnormalities
PubMed: 25044170
DOI: 10.1002/ajmg.a.36683 -
Proceedings of the Royal Society of... Sep 1943
PubMed: 19992724
DOI: No ID Found -
Cutaneous and Ocular Toxicology Jun 2011Sulfur mustard (SM) is a potent chemical warfare agent that was widely used during the First World War and the Iran-Iraq conflict. This vesicant agent causes several...
Sulfur mustard (SM) is a potent chemical warfare agent that was widely used during the First World War and the Iran-Iraq conflict. This vesicant agent causes several acute and chronic effects on the skin, eye, and respiratory system. We report the case of a 41-year-old man who was injured with SM in Iraq chemical attack in 1988. After exposure, he developed severe skin blisters on his upper trunk, dorsum of hands, and genitalia. Based on several clinical observations, such as atrophy, pigmentation, and vascular changes on genitalia with relevant findings in histopathological studies, persistent pigmentation, and damaged skin appendix in hand lesions, a diagnosis of "SM-induced poikiloderma" was postulated. The absence of any complication on the palmar aspect of hands is another remarkable finding in presented case, which suggests a plausible role of the palms as a vector for transporting SM to other sites of the skin.
Topics: Adult; Chemical Warfare Agents; Dermatitis, Irritant; Humans; Male; Mustard Gas
PubMed: 21142708
DOI: 10.3109/15569527.2010.539585