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Reumatizam 2008The etiology, pathogenesis, epidemiology, clinical picture, diagnosis, differential diagnosis and treatment of polymyalgia reumatica are presented. (Review)
Review
The etiology, pathogenesis, epidemiology, clinical picture, diagnosis, differential diagnosis and treatment of polymyalgia reumatica are presented.
Topics: Diagnosis, Differential; Humans; Polymyalgia Rheumatica
PubMed: 19024276
DOI: No ID Found -
International Journal of Environmental... Jan 2023Elderly-onset rheumatoid arthritis (EORA) is prevalent among older patients, and its incidence is increasing due to aging societies. However, differentiating between... (Review)
Review
Elderly-onset rheumatoid arthritis (EORA) is prevalent among older patients, and its incidence is increasing due to aging societies. However, differentiating between EORA and polymyalgia rheumatica (PMR) is challenging for clinicians and hinders the initiation of effective treatment for rheumatoid arthritis among older generations, thereby allowing its progression. Therefore, we conducted a qualitative synthesis of narrative reviews via meta-ethnography regarding seronegative EORA diagnosis to clarify the methods to differentiate seronegative EORA from PMR. Three databases (PubMed, EMBASE, and Web of Science) were searched for relevant reviews published between January 2011 and October 2022. The extracted articles were synthesized using meta-ethnography, and 185 studies were selected following the protocol. Seven reviews were analyzed, and four themes and nine concepts were identified. The four themes included difficulty in differentiation, mandatory follow-up, and factors favoring rheumatoid arthritis and those favoring PMR. Factors favoring seronegative EORA and PMR should be considered for effective diagnosis and prompt initiation of disease-modifying anti-rheumatic drugs. Mandatory and long follow-ups of suspected patients are essential for differentiating the two diseases. The attitude of rheumatologists toward tentatively diagnosing seronegative EORA and flexibly modifying their hypotheses based on new or altered symptoms can aid in effective management and avoiding misdiagnosis.
Topics: Humans; Aged; Polymyalgia Rheumatica; Arthritis, Rheumatoid
PubMed: 36767155
DOI: 10.3390/ijerph20031789 -
Clinical Medicine (London, England) Dec 2010
Topics: Biomarkers; Disease Progression; Glucocorticoids; Humans; Immunosuppressive Agents; Polymyalgia Rheumatica; Prognosis; Severity of Illness Index
PubMed: 21413499
DOI: 10.7861/clinmedicine.10-6-641 -
Zeitschrift Fur Rheumatologie Feb 2013Polymyalgia rheumatica is characterized by bilateral pain in the shoulder and pelvic girdles, malaise, morning stiffness and weight loss. The erythrocyte sedimentation...
Polymyalgia rheumatica is characterized by bilateral pain in the shoulder and pelvic girdles, malaise, morning stiffness and weight loss. The erythrocyte sedimentation rate (ESR) and the C-reactive protein (CRP) level are elevated. Imaging using ultrasound, magnetic resonance imaging (MRI) or positron emission tomography (PET) displays inflammatory changes in the painful anatomical areas. Nearly all patients are older than 50 years and the average age is 70-75 years. Polymyalgia rheumatica occurs 2-3 times more often in women than in men and some patients exhibit temporal arteritis or giant cell arteritis. Symptoms rapidly decrease with glucocorticoid treatment and the dose can normally be reduced during the course of the disease. Methotrexate may be given only if high glucocorticoid doses do not sufficiently control symptoms. On average treatment can be stopped after 2 years.
Topics: Antirheumatic Agents; Diagnostic Imaging; Female; Glucocorticoids; Humans; Male; Methotrexate; Polymyalgia Rheumatica
PubMed: 23392601
DOI: 10.1007/s00393-012-1103-8 -
Disease-a-month : DM Jan 1974
Review
Topics: Age Factors; Aged; Arteritis; Blood Sedimentation; Blood Vessels; Diagnosis, Differential; Female; Humans; Male; Microscopy, Electron; Middle Aged; Muscles; Polymyalgia Rheumatica; Prednisone; Steroids; Vision Disorders
PubMed: 4590802
DOI: 10.1016/s0011-5029(74)80005-2 -
Rheumatic Diseases Clinics of North... Aug 2000PMR and GCA are related conditions that seem to represent a continuum of disease. These conditions are relatively common and seem to be mediated by a cellular... (Review)
Review
PMR and GCA are related conditions that seem to represent a continuum of disease. These conditions are relatively common and seem to be mediated by a cellular inflammatory response. Increasing evidence suggests an infectious cause (or causes) precipitating this immune response in genetically susceptible individuals. Whereas previously thought to affect primarily branch vessels of the aortic arch, GCA is now thought of as a disease in which proximal aortic involvement is frequent. Despite the potential for serious, even fatal complications, overall prognosis for patients with GCA or PMR is excellent. Corticosteroids remain the standard treatment, although not curative. Whereas the ESR is a useful indicator of disease activity, other markers which may be more precise such as creative protein and Il-6 seem to offer added information about disease activity.
Topics: Aged; Aging; Humans; Polymyalgia Rheumatica
PubMed: 10989509
DOI: 10.1016/s0889-857x(05)70153-8 -
Journal of the American Geriatrics... Feb 1976Polymyalgia rheumatica should be considered when a syndrome of constitutional symptoms, especially weight loss, low-grade fever, weakness, wasting proximal muscles,...
Polymyalgia rheumatica should be considered when a syndrome of constitutional symptoms, especially weight loss, low-grade fever, weakness, wasting proximal muscles, fatigue, malaise and depression, is seen in the elderly. Giant-cell arteritis plays a part later in the course. Thus the need for biopsy of a long segment of the temporal artery to help in determining diagnosis and therapy. An elevated erythrocyte sedimentation rate (ESR) is an important clue. The usual high value is about 80 mm/hour; if it is over 100 mm/hour, giant-cell arteritis should be suspected. Salicylates, indomethacin, phenylbutazone and hydroxychloroquine produce some clinical improvement but do not lower the high ESR; moreover, the patients are prone to experience relapses. Prednisone, however, not only produces clinical improvement but lowers the high ESR. Potassium p-aminobenzoate may be useful in maintaining the remission.
Topics: Aged; Blood Sedimentation; Female; Humans; Indomethacin; Male; Middle Aged; Polymyalgia Rheumatica; Prednisone
PubMed: 1249388
DOI: 10.1111/j.1532-5415.1976.tb03296.x -
Polskie Archiwum Medycyny Wewnetrznej Jun 2008Polymyalgia rheumatica (PMR) is a common disease of the elderly. It is characterized by pain and stiffness in the neck, shoulders and the pelvic girdle. In most cases... (Review)
Review
Polymyalgia rheumatica (PMR) is a common disease of the elderly. It is characterized by pain and stiffness in the neck, shoulders and the pelvic girdle. In most cases erythrocyte sedimentation rate and C-reactive protein levels are highly elevated. Polymyalgia rheumatica is frequently associated with giant cell arteritis. Steroids are the standard treatment for PMR but their dosage requires adjustment depending on clinical picture, co-morbid conditions and adverse effects. The most prominent features of the disease as well as the main principles of treatment are presented.
Topics: Blood Sedimentation; C-Reactive Protein; Diagnosis, Differential; Glucocorticoids; Humans; Polymyalgia Rheumatica; Prednisone
PubMed: 18619195
DOI: No ID Found -
Clinical and Experimental Rheumatology 2021
Topics: Acute-Phase Proteins; Diagnosis, Differential; Giant Cell Arteritis; Glucocorticoids; Humans; Polymyalgia Rheumatica
PubMed: 33124579
DOI: 10.55563/clinexprheumatol/s4c5k3 -
Deutsche Medizinische Wochenschrift... Jan 2009
Review
Topics: Adrenal Cortex Hormones; Aged; Diagnosis, Differential; Female; Giant Cell Arteritis; Humans; Immunosuppressive Agents; Methotrexate; Polymyalgia Rheumatica; Tumor Necrosis Factor-alpha
PubMed: 19148856
DOI: 10.1055/s-0028-1123971