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Biochimica Et Biophysica Acta Apr 1956
Topics: Azotobacter; Azotobacter vinelandii; Phosphorylases; Polynucleotides; Polyribonucleotide Nucleotidyltransferase
PubMed: 13315374
DOI: 10.1016/0006-3002(56)90286-4 -
Molecules (Basel, Switzerland) Mar 2008Water soluble homo-base polynucleotide analogues were synthesized in which polyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto...
Water soluble homo-base polynucleotide analogues were synthesized in which polyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetal formation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotide analogs exhibited hyperchromic effects, which was not the case for the corresponding uracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotide analogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature and melting curves with melting points at approximately 40 degrees C.
Topics: Adenine; Phosphates; Polynucleotides; Polyvinyl Alcohol; Solubility; Spectrophotometry, Ultraviolet; Temperature; Uracil
PubMed: 18463571
DOI: 10.3390/molecules13030701 -
Bulletin of Mathematical Biology 1985
Comparative Study
Topics: Biological Evolution; Biometry; Models, Biological; Polynucleotides
PubMed: 4027436
DOI: 10.1007/BF02460034 -
Biochemical and Biophysical Research... Nov 1965
Topics: Adenine Nucleotides; Chemical Phenomena; Chemistry; Magnesium; Polynucleotides; Spectrophotometry; Uracil Nucleotides
PubMed: 5865504
DOI: 10.1016/0006-291x(65)90203-2 -
The Journal of Biological Chemistry Apr 1957
Topics: Bacteria; Phosphorylases; Polynucleotides; Polyribonucleotide Nucleotidyltransferase; Vegetables
PubMed: 13416286
DOI: No ID Found -
Biochimica Et Biophysica Acta Jun 1972
Topics: Circular Dichroism; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Optical Rotatory Dispersion; Osmolar Concentration; Poly I-C; Polynucleotides; Sodium Chloride; Spectrometry, Fluorescence; Ultraviolet Rays
PubMed: 5043712
DOI: No ID Found -
Biomacromolecules 2005Natural Curdlan adopts a right-handed 6(1) triple helix, in which the constituting glucan chains are underpinned with each other by the intermolecular hydrogen bonds....
Natural Curdlan adopts a right-handed 6(1) triple helix, in which the constituting glucan chains are underpinned with each other by the intermolecular hydrogen bonds. Curdlan can form a stoichiometric complex with polynucleotides [e.g., poly(cytidylic acid), poly(C)]. In this paper, we carried out the MOPAC (semiempirical molecular-orbital package) calculation to examine the molecular structure of the Curdlan/poly(C) complex. The calculation exhibited that two types of hydrogen bonds are formed between the Curdlan and the poly(C); the third nitrogen (N3) in cytosine forms a hydrogen bond with the second OH of one Curdlan chain, and the proton of N4 is interacting with the O2 of another Curdlan chain. In our model, the helix diameter of poly(C) is expanded from 11.0 to 15.3 A upon complexation. Despite such large conformational changes, the 6(1) helix structure of poly(C) was maintained even after the complexation. This fact is complementary to the experimental fact that the complexation does not change the band shape of the circular dichroism of poly(C). The chain length dependence of the reaction enthalpy indicated that the complexation becomes thermodynamically more favorable with the chain length increasing. This feature is also consistent with the experimental data.
Topics: Carbohydrate Conformation; Computational Biology; Poly C; Polynucleotides; Polysaccharides; Protein Structure, Secondary; beta-Glucans
PubMed: 15877376
DOI: 10.1021/bm049218u -
Electrophoresis Aug 2002In an effort to understand recent experiments, we have performed Brownian dynamics simulations of polymer translocation through nanometer-scale protein pores under the...
In an effort to understand recent experiments, we have performed Brownian dynamics simulations of polymer translocation through nanometer-scale protein pores under the influence of an external applied electric field. Multiple peaks in the translocation time distribution are observed in agreement with experiments. Under the same conditions, but replacing the protein pore with a rigid cylindrical tube of comparable size, only a single peak is observed in the translocation time distribution. These results directly show that the geometry of the protein pores is mainly responsible for multiple peaks observed in experiments. In the case of alpha-hemolysin channel, we find the vestibule, by confining many conformations of the translocating polymer, to be responsible for the second peak with longer translocation time.
Topics: Biological Transport; Hemolysin Proteins; Kinetics; Membrane Transport Proteins; Membranes, Artificial; Models, Biological; Models, Molecular; Permeability; Polynucleotides; Porosity
PubMed: 12210174
DOI: 10.1002/1522-2683(200208)23:16<2697::AID-ELPS2697>3.0.CO;2-M -
Biochimica Et Biophysica Acta Sep 1964
Topics: Amino Acids; Antimetabolites; Hydroxylamines; Nucleosides; Oxidation-Reduction; Periodic Acid; Polynucleotides; Research; Ribosomes
PubMed: 14227282
DOI: No ID Found -
Biochimica Et Biophysica Acta Dec 1966
Topics: Azotobacter; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Nucleic Acids; Nucleotidyltransferases; Polymers; Polynucleotides; Spectrophotometry; Temperature; Ultraviolet Rays; Xanthines
PubMed: 5965728
DOI: No ID Found