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Southern Medical Journal Mar 1962
Topics: Chlorothiazide; Hypertension; Polythiazide
PubMed: 14456638
DOI: 10.1097/00007611-196203000-00018 -
Wiener Medizinische Wochenschrift (1946) Apr 1966
Topics: Blood Glucose; Blood Pressure; Chlorine; Chlorthalidone; Diuresis; Edema; Female; Humans; Polythiazide; Potassium; Pregnancy; Pregnancy Complications; Sodium; Uric Acid
PubMed: 5985503
DOI: No ID Found -
Clinical Pharmacology and Therapeutics Feb 1978An assay for polythiazide, sufficiently sensitive to measure plasma concentrations of this high-potency diuretic agent, has been developed. The assay is based on acid...
An assay for polythiazide, sufficiently sensitive to measure plasma concentrations of this high-potency diuretic agent, has been developed. The assay is based on acid hydrolysis to trifluoroethylthioacetaldehyde and electron-capture gas chromatography. Sensitivity down to 0.2 ng/ml was achieved. In a study in normal human subjects receiving single 1-mg oral doses of polythiazide, the mean plasma half-lives for absorption and elimination were 1.2 and 25.7 hr, respectively. The latter is consistent with the extended duration of action of polythiazide. Approximately 25% of the drug was excreted unchanged in the urine.
Topics: Adolescent; Adult; Chromatography, Gas; Female; Humans; Kinetics; Male; Middle Aged; Polythiazide
PubMed: 620486
DOI: 10.1002/cpt1978232241 -
Annals of Internal Medicine Dec 1971
Topics: Adult; Aged; Alkalosis; Bendroflumethiazide; Biological Assay; Blood Urea Nitrogen; Bromine; Carbon Dioxide; Chlorides; Chlorpropamide; Chlorthalidone; Creatinine; Diagnosis, Differential; Diuretics; Female; Furosemide; Humans; Hydrochlorothiazide; Hypokalemia; Hyponatremia; Hypopituitarism; Hypothyroidism; Male; Methyclothiazide; Middle Aged; Natriuresis; Osmolar Concentration; Polythiazide; Potassium Isotopes; Radioisotope Dilution Technique; Radioisotopes; Sodium Isotopes; Tritium; Vasopressins; Vomiting; Water-Electrolyte Balance
PubMed: 4944156
DOI: 10.7326/0003-4819-75-6-853 -
Angiology Apr 1964
Topics: Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Diuretics; Gastroenteritis; Geriatrics; Gout; Hypertension; Nitrogen; Polythiazide; Prognosis; Reserpine; Toxicology; Uric Acid; Vertigo; Water-Electrolyte Balance
PubMed: 14159227
DOI: 10.1177/000331976401500407 -
Journal of Chromatography Jun 1981A selective high-performance liquid chromatographic method has been developed for the determination of polythiazide in human plasma down to concentrations of 0.5 ng/ml....
A selective high-performance liquid chromatographic method has been developed for the determination of polythiazide in human plasma down to concentrations of 0.5 ng/ml. Polythiazide and an internal standard (epithiazide) are simultaneously extracted from the sample, the extract is purified on a silica micro-column and analyzed on a muBondapak CN column. Chloroform-methanol (97:3) is the eluent, with spectrophotometric detection at 264 nm. The extraction methodology developed for the analysis of polythiazide in blood plasma allows the simultaneous quantitative determination of prazosin, which is frequently administered together with thiazide diuretics. The precision and accuracy of both the polythiazide and the prazosin assays are excellent and are not seriously affected by the simultaneous presence of both drugs in the plasma. Therefore, determination of polythiazide and prazosin is possible using a single plasma sample.
Topics: Chromatography, High Pressure Liquid; Humans; Polythiazide; Prazosin; Quinazolines
PubMed: 7263818
DOI: 10.1016/s0378-4347(00)80135-8 -
Western Medicine; the Medical Journal... Nov 1963
Topics: Benzothiadiazines; Edema; Hypertension; Polythiazide
PubMed: 14081384
DOI: No ID Found -
The British Journal of Clinical Practice Jun 1962
Topics: Chlorothiazide; Edema; Edetic Acid; Polythiazide
PubMed: 13864329
DOI: No ID Found