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British Heart Journal Oct 1972
Topics: Adult; Black or African American; Blood Pressure; Bronchial Spasm; Drug Synergism; Female; Hallucinations; Humans; Hypertension; Male; Middle Aged; Polythiazide; Propranolol; Pulse; Racial Groups; Sleep Wake Disorders; Substance Withdrawal Syndrome; Vertigo
PubMed: 5086971
DOI: 10.1136/hrt.34.10.1042 -
American Journal of Physiology. Renal... Oct 2023The primary structure of the thiazide-sensitive NaCl cotransporter (NCC) was resolved 30 years ago by the molecular identification of the cDNA encoding this... (Review)
Review
The primary structure of the thiazide-sensitive NaCl cotransporter (NCC) was resolved 30 years ago by the molecular identification of the cDNA encoding this cotransporter, from the winter's flounder urinary bladder, following a functional expression strategy. This review outlines some aspects of how the knowledge about thiazide diuretics and NCC evolved, the history of the cloning process, and the expansion of the SLC12 family of electroneutral cotransporters. The diseases associated with activation or inactivation of NCC are discussed, as well as the molecular model by which the activity of NCC is regulated. The controversies in the field are discussed as well as recent publication of the three-dimensional model of NCC obtained by cryo-electron microscopy, revealing not only the amino acid residues critical for Na and Cl translocation but also the residues critical for polythiazide binding to the transporter, opening the possibility for a new era in thiazide diuretic therapy.
Topics: Solute Carrier Family 12, Member 3; Protein Serine-Threonine Kinases; Sodium Chloride; Cryoelectron Microscopy; Sodium Chloride Symporter Inhibitors; Cloning, Molecular
PubMed: 37560773
DOI: 10.1152/ajprenal.00114.2023 -
The Journal of the Albert Einstein... Jul 1963
Topics: Benzothiadiazines; Diuretics; Geriatrics; Heart Failure; Polythiazide
PubMed: 14044069
DOI: No ID Found -
Acta Crystallographica. Section E,... Jun 2010The crystal structure of the title compound, C(11)H(13)ClF(3)N(3)O(4)S(3) (systematic name:...
The crystal structure of the title compound, C(11)H(13)ClF(3)N(3)O(4)S(3) (systematic name: 6-chloro-2-methyl-3-{[(2,2,2-trifluoro-eth-yl)sulfan-yl]meth-yl}-3,4-dihydro-2H-1,2,4-benzothia-diazine-7-sul-f-on-amide 1,1-diox-ide; CRN: 346-18-9), exhibits a two-dimensional network of hydrogen-bonded mol-ecules parallel to (01). The NH and NH(2) groups act as donor sites and the sulfonyl O atoms as acceptor sites in N-H⋯O hydrogen bonds, and a C-H⋯O interaction also occurs. The thiadiazine ring adopts an envelope conformation with the N atom bonded to sulfur at the tip of the flap, and the methyl substituent is in an axial position.
PubMed: 21587890
DOI: 10.1107/S1600536810022105 -
Geriatrics Dec 1965
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Blood; Chlorides; Edema; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Polythiazide; Potassium; Sodium; Urine
PubMed: 5842249
DOI: No ID Found -
Revista Clinica Espanola May 1963
Topics: Diuretics; Hypertension; Polythiazide
PubMed: 13960436
DOI: No ID Found -
Journal of the Indian Medical... Jan 1967
Comparative Study
Topics: Adolescent; Adult; Aged; Edema; Female; Heart Failure; Humans; Hydrochlorothiazide; Liver Cirrhosis; Male; Middle Aged; Nephrotic Syndrome; Organomercury Compounds; Polythiazide
PubMed: 6040102
DOI: No ID Found -
Journal of the Indian Medical... Jun 1964
Topics: Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood Chemical Analysis; Blood Protein Disorders; Diuretics; Drug Therapy; Edema; Heart Failure; Humans; Hypertension; Hypertension, Portal; Hypokalemia; Hypoproteinemia; Liver Cirrhosis; Polythiazide; Research; Toxicology; Water-Electrolyte Balance
PubMed: 14171281
DOI: No ID Found -
Proceedings of the Society For... 1962
Topics: Chlorothiazide; Kidney; Polythiazide; Urinary Tract Physiological Phenomena
PubMed: 13910051
DOI: 10.3181/00379727-110-27677 -
Applied Therapeutics Jul 1965
Topics: Adult; Diuresis; Humans; Polythiazide; Water-Electrolyte Balance
PubMed: 5877552
DOI: No ID Found