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Current Therapeutic Research, Clinical... Mar 1964
Topics: Benzothiadiazines; Bicarbonates; Biomedical Research; Blood Chemical Analysis; Blood Pressure; Blood Pressure Determination; Blood Proteins; Chlorides; Diuretics; Electrolytes; Humans; Hydrogen-Ion Concentration; Hypertension; Polythiazide; Potassium; Sodium; Sodium, Dietary; Water; Water-Electrolyte Balance
PubMed: 14131416
DOI: No ID Found -
Annals of the New York Academy of... Mar 1968
Topics: Adrenal Gland Neoplasms; Animals; Carcinoma; Cerebellar Neoplasms; Erythropoietin; Female; Hemangiosarcoma; Humans; Hypertension, Renal; Kidney; Kidney Diseases; Kidney Neoplasms; Liver Neoplasms; Neoplasms; Pheochromocytoma; Polycythemia; Polythiazide; Rats; Renin; Uterine Neoplasms
PubMed: 5240746
DOI: 10.1111/j.1749-6632.1968.tb15192.x -
Journal of Pharmaceutical and... 1989A quantitative spectrophotometric method using Pd(II) chloride as analytical reagent for the determination of polythiazide in pharmaceutical preparations is described in...
A quantitative spectrophotometric method using Pd(II) chloride as analytical reagent for the determination of polythiazide in pharmaceutical preparations is described in this study. It has been found that polythiazide reacts with Pd(II) chloride in the pH range 3.6-5.8, forming a red, water-soluble (1:1) complex with maximum absorbance at 527 nm. At the optimum pH of 4.8 and an ionic strength mu = 0.1 M, the conditional stability constant of the complex is found to be log K' = 4.77. The molar absorptivity at 527 nm is 3.2 x 10(3) l mol-1 cm-1. Good agreement with Beer's law was found for polythiazide concentrations up to 2.2 mmol l-1. The nominal percent recovery of polythiazide was 99.5% (n = 20). The simplicity, selectivity and sensitivity of the method described is suitable for rapid and accurate determinations of polythiazide in tablets.
Topics: Drug Stability; Hydrogen-Ion Concentration; Indicators and Reagents; Palladium; Polythiazide; Spectrophotometry, Ultraviolet; Tablets
PubMed: 2490543
DOI: 10.1016/0731-7085(89)80165-7 -
Henry Ford Hospital Medical Bulletin Dec 1962
Topics: Benzothiadiazines; Heart Failure; Polythiazide
PubMed: 14032221
DOI: No ID Found -
The Journal of the Medical Society of... Jan 1962
Topics: Chlorothiazide; Diuretics; Polythiazide
PubMed: 13872494
DOI: No ID Found -
American Heart Journal Nov 1983Data are presented on 22 hypertensive patients in an 18-week, double-blind comparison of trimazosin and methyldopa during which treatment with polythiazide was... (Clinical Trial)
Clinical Trial Comparative Study
Data are presented on 22 hypertensive patients in an 18-week, double-blind comparison of trimazosin and methyldopa during which treatment with polythiazide was continued. Maximum daily doses of trimazosin and methyldopa were 800 and 2000 mg, respectively. Eight of nine patients receiving trimazosin and 8 of 12 receiving methyldopa had excellent or good overall responses. (One trimazosin patient was not evaluated for overall response.) Quantitative criteria of blood pressure response indicated that trimazosin was as effective as methyldopa. There were no clinically significant changes in results of Holter monitor recordings, ECGs, chest x-ray films, cardiopulmonary tests, or ophthalmoscopy. There were no abnormalities in laboratory tests of trimazosin patients. One patient receiving methyldopa had a positive Coombs' test. Significant side effects developed in two methyldopa patients-syncope in one patient and postural hypotension in the other. No significant side effects occurred in the patients taking trimazosin.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Piperazines; Polythiazide
PubMed: 6356853
DOI: 10.1016/0002-8703(83)90184-9 -
Michigan Medicine Sep 1964
Topics: Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Diabetes Mellitus; Diuretics; Edema; Geriatrics; Gout; Polythiazide; Toxicology
PubMed: 14180243
DOI: No ID Found -
Current Therapeutic Research, Clinical... Apr 1963
Topics: Benzothiadiazines; Diuretics; Pharmacology, Clinical; Polythiazide
PubMed: 13987798
DOI: No ID Found -
The Journal of the Association of... Nov 1965
Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Polythiazide; Reserpine
PubMed: 5852366
DOI: No ID Found -
The Practitioner Feb 1966
Clinical Trial Comparative Study
Topics: Antihypertensive Agents; Clinical Trials as Topic; Humans; Hypertension; Polythiazide
PubMed: 5322962
DOI: No ID Found