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Ginecologia Y Obstetricia de Mexico 1966
Topics: Adolescent; Adult; Female; Humans; Polythiazide; Pre-Eclampsia; Pregnancy; Water-Electrolyte Balance
PubMed: 5998579
DOI: No ID Found -
The Journal of International Medical... 1981In a multicentre study conducted by thirty-two investigators in ten European, Asian, and Latin-American countries the combination of prazosin 0.5 mg and polythiazide...
In a multicentre study conducted by thirty-two investigators in ten European, Asian, and Latin-American countries the combination of prazosin 0.5 mg and polythiazide 0.25 mg per tablet was used as the only drug treatment for all grades of hypertension in 551 adult male and female out-patients. After a 2-week placebo period, patients received 1 tablet daily. The dosage was increased, as necessary, by 1 tablet every 2 weeks to a maximum of 4 tablets daily to provide an adequate blood pressure response. Duration of therapy averaged 7.8 weeks. Blood pressure was reduced by an average of 15% systolic and 17% diastolic and the degree of severity of blood pressure improved in 93% of patients. Two-thirds of the patients ended the study with a diastolic blood pressure equal to or less than 90 mm Hg. The dosage at the end of the therapy period averaged 2 tablets of Minizide as a single daily dose. Side-effects were mostly mild or moderate and were typical of those expected for antihypertensive medication. It is concluded that this combination drug is efficacious in the treatment of hypertension and, together with its good toleration profile and ease of administration, will enhance compliance with therapy.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Drug Combinations; Female; Humans; Hypertension; Male; Middle Aged; Polythiazide; Prazosin; Quinazolines
PubMed: 7297754
DOI: 10.1177/030006058100900501 -
Acta Medica Scandinavica Jul 1964
Topics: Alkalosis; Biomedical Research; Chlorides; Chlorthalidone; Drug Therapy; Hypertension; Hypokalemia; Polythiazide; Potassium; Toxicology
PubMed: 14194190
DOI: 10.1111/j.0954-6820.1964.tb00644.x -
Journal of the Indian Medical... Mar 1973
Comparative Study
Topics: Adult; Aged; Drug Combinations; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Polythiazide; Reserpine
PubMed: 4723077
DOI: No ID Found -
The Journal of the Association of... Jan 1968
Comparative Study
Topics: Adolescent; Adult; Aged; Chlorthalidone; Diabetes Mellitus; Humans; Middle Aged; Polythiazide
PubMed: 5655059
DOI: No ID Found -
Current Therapeutic Research, Clinical... Sep 1961
Topics: Antihypertensive Agents; Chlorothiazide; Diuretics; Polythiazide
PubMed: 13775251
DOI: No ID Found -
Postgraduate Medicine Nov 1975Preliminary results of a study of 20 patients show a combination of prazosin and polythiazide to be effective in controlling hypertension not responsive to the diuretic... (Clinical Trial)
Clinical Trial
Preliminary results of a study of 20 patients show a combination of prazosin and polythiazide to be effective in controlling hypertension not responsive to the diuretic alone. The maximum useful dosage of prazosin was not defined, but increasing the dosage above 15 mg a day did not improve control of blood pressure.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Piperazines; Polythiazide; Posture; Quinazolines
PubMed: 1105488
DOI: No ID Found -
Indian Heart Journal Jan 1968
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Child; Drug Synergism; Female; Humans; Hypertension; Male; Middle Aged; Polythiazide
PubMed: 5657505
DOI: No ID Found -
Svenska Lakartidningen Sep 1963
Topics: Humans; Hypoglycemic Agents; Pharmacology; Polythiazide; Thiazides
PubMed: 14091722
DOI: No ID Found -
Journal de Medecine de Bordeaux Et Du... May 1967
Topics: Age Factors; Aged; Female; Humans; Hypertension; Male; Polythiazide
PubMed: 5608065
DOI: No ID Found