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JAMA Nov 1964
Topics: Aortic Valve Stenosis; Arteriosclerosis; Ascites; Atrial Fibrillation; Biomedical Research; Cardiomegaly; Diabetic Angiopathies; Diabetic Nephropathies; Diuretics; Drug Therapy; Edema; Geriatrics; Heart Failure; Humans; Hypertension; Injections, Intramuscular; Liver Cirrhosis; Mitral Valve Insufficiency; Mitral Valve Stenosis; Organomercury Compounds; Organometallic Compounds; Pleural Effusion; Polythiazide; Purines; Rheumatic Heart Disease; Sodium
PubMed: 14215515
DOI: 10.1001/jama.1964.03070200007001 -
The Journal of the Medical Society of... May 1962
Topics: Heart Failure; Humans; Polythiazide
PubMed: 13866351
DOI: No ID Found -
The American Journal of the Medical... May 1965
Topics: Biomedical Research; Blood Chemical Analysis; Blood Pressure; Body Weight; Chlorthalidone; Diuresis; Double-Blind Method; Drug Therapy; Heart Failure; Hypertension; Pharmacology; Placebos; Polythiazide; Potassium; Sodium; Toxicology
PubMed: 14280897
DOI: No ID Found -
Current Therapeutic Research, Clinical... Feb 1977
Clinical Trial
Topics: Adult; Drug Therapy, Combination; Humans; Hypertension; Hypokalemia; Male; Polythiazide; Potassium; Prazosin; Propanolamines; Quinazolines
PubMed: 403051
DOI: No ID Found -
Current Therapeutic Research, Clinical... Dec 1976
Clinical Trial
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertension; Middle Aged; Polythiazide; Posture; Prazosin; Quinazolines
PubMed: 827421
DOI: No ID Found -
High-pressure liquid chromatographic analysis of polythiazide in pharmaceutical tablet formulations.Journal of Pharmaceutical Sciences May 1977A high-pressure liquid chromatographic method was developed for the quantitative determination of polythiazide in pharmaceutical tablet formulations after extraction of...
A high-pressure liquid chromatographic method was developed for the quantitative determination of polythiazide in pharmaceutical tablet formulations after extraction of the powdered tablets with a water-acetonitrile solvent. Analysis is a accomplished by comparison of peak areas after chromatography.
Topics: Chromatography, High Pressure Liquid; Methods; Polythiazide; Tablets
PubMed: 874763
DOI: 10.1002/jps.2600660535 -
Journal - Association of Official... Jan 1974
Topics: Adsorption; Chromatography, Thin Layer; Glass; Methods; Polythiazide; Solvents; Tablets
PubMed: 4814331
DOI: No ID Found -
Photodermatology, Photoimmunology &... Feb 1996A number of sulphonamide-derived oral antidiabetics (chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide and tolbutamide) and diuretics...
A number of sulphonamide-derived oral antidiabetics (chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide and tolbutamide) and diuretics (bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chloratalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and xipamide) were investigated for phototoxicity in a cell culture model. Cell death dependent on ultraviolet A fluence and test substance concentration was observed in the presence of the oral antidiabetics glibenclamide and gliquidone, as well as the diuretics bemetizide, bendroflumethiazide, benzyl-hydrochlorothiazide, bumetanide, butizide, hydrochlorothiazide, hydroflumethiazide, piretanide, polythiazide and trichlormethiazide. Bendroflumethiazide was phototoxic at 5x10(-5) M and higher concentrations, bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 2.5x10(-4) M and higher concentrations, and the oral antidiabetics glibenclamide and gliquidone as well as the diuretics butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 5(-4) M and higher concentrations. Electron microscopic investigations showed swelling of mitochondria and endoplasmic reticulum as well as aggregation of euchromatin when the cells were irradiated in the presence of photosensitizers.
Topics: Administration, Oral; Cell Death; Cells, Cultured; Dermatitis, Phototoxic; Diuretics; Humans; Hypoglycemic Agents; Radiation Dosage; Sulfonamides; Ultraviolet Rays
PubMed: 8884891
DOI: 10.1111/j.1600-0781.1996.tb00235.x -
JAMA Apr 1963
Topics: Antihypertensive Agents; Chlorothiazide; Double-Blind Method; Polythiazide
PubMed: 13990101
DOI: 10.1001/jama.1963.03700160067010 -
International Journal of Clinical... Jan 1979
Clinical Trial Comparative Study
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Polythiazide; Prazosin; Pulse; Quinazolines; Renin
PubMed: 367977
DOI: No ID Found