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The Journal of Dermatology Aug 1980
Topics: Adenoma, Sweat Gland; Adolescent; Adult; Aged; Female; Foot Diseases; Heel; Humans; Male; Middle Aged; Phosphorylases; Sweat Gland Neoplasms
PubMed: 6252254
DOI: 10.1111/j.1346-8138.1980.tb01967.x -
International Journal of Dermatology Sep 2021
Topics: Ananas; Dermoscopy; Diagnosis, Differential; Humans; Poroma; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 33728651
DOI: 10.1111/ijd.15525 -
Annales de Dermatologie Et de... Sep 2019
Topics: Back; Female; Humans; Middle Aged; Poroma; Sweat Gland Neoplasms
PubMed: 30910337
DOI: 10.1016/j.annder.2019.02.007 -
Clinical Case Reports Dec 2019Poroma, a benign sweat tumor, commonly presents with a nontender papule on the extremities. It can appear with a blinking light appearance on dermoscopy in real time.
Poroma, a benign sweat tumor, commonly presents with a nontender papule on the extremities. It can appear with a blinking light appearance on dermoscopy in real time.
PubMed: 31893072
DOI: 10.1002/ccr3.2520 -
Journal of Cutaneous Medicine and... 2021A poroma typically presents as a solitary, pink-to-red papule or nodule in acral volar areas. However, in nonvolar areas, this typical clinical feature (TCF) can be...
BACKGROUND
A poroma typically presents as a solitary, pink-to-red papule or nodule in acral volar areas. However, in nonvolar areas, this typical clinical feature (TCF) can be difficult to identify.
OBJECTIVE
We aimed to compare clinical and dermoscopic characteristics between nonvolar poroma (NVP) and volar (ie, typical) poroma (VP).
METHODS
We assessed the clinical and dermoscopic characteristics of 40 patients with poromas who were divided into the NVP and VP groups.
RESULTS
Of the 40 patients, 20 (50.0%) were allocated to the NVP group and 20 (50.0%) to the VP group. Pigmented variants were more common in the NVP group than in the VP group (60.0% vs 5.0%). The TCF of poroma was observed less frequently in the NVP than the VP group (45.0% vs 85.0%). Approximately one-third (30.0%) of patients with NVP received an initial clinical diagnosis of skin cancer. Dermoscopic patterns associated with melanoma or basal cell carcinoma were more common in the NVP group than in the VP group (65% vs 30%).
CONCLUSIONS
Skin cancer-associated clinicodermoscopic features were more frequently observed in patients with NVP, who simultaneously lost dermoscopic patterns associated to poromas and acquired those associated with skin cancer, than those with VP.
Topics: Adult; Aged; Aged, 80 and over; Dermoscopy; Female; Humans; Male; Middle Aged; Poroma; Sweat Gland Neoplasms
PubMed: 32880198
DOI: 10.1177/1203475420952432 -
The American Journal of Dermatopathology Jun 2018There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors...
There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89.6%), infundibular follicular structures (66.7%), and entrapped sebocytes (56.3%). No definite apocrine decapitation secretions in FSPT were found. Immunohistochemistry was strongly positive for CK903 and focally positive for CAM5.2, epithelial membrane antigen, and carcinoembryonic antigen. No loss of MLH-1, MSH-2, or MSH-6 mismatch repair proteins was found. FSPT had distinctive features that differentiate them from eccrine poromas including the frequent head and neck locations (62.5% vs. 20.6%, P < 0.01), squamous cytology (100% vs. 1.6%, P < 0.01), more prominent cytoplasmic vacuolization (score 1.4/4.0 vs. 0.3/4.0, P < 0.01), presence of infundibular follicular structures (score 1.2/4.0 vs. 0.03/4.0, P < 0.01), presence of ducts with steatocystoma-like cuticles (89.6% vs. 0.0%, P < 0.01), and less stromal hyalinization (score 1.0/4.0 vs. 2.5/4.0, P < 0.01). The authors propose that FSPT are distinctive benign tumors originating from the sebaceous gland duct and are therefore best categorized as holocrine poroma.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Poroma; Sweat Gland Neoplasms; Young Adult
PubMed: 29095742
DOI: 10.1097/DAD.0000000000001046 -
Histopathology May 2023Recently, YAP1 fusion genes have been demonstrated in eccrine poroma and porocarcinoma, and the diagnostic use of YAP1 immunohistochemistry has been highlighted in this...
AIMS
Recently, YAP1 fusion genes have been demonstrated in eccrine poroma and porocarcinoma, and the diagnostic use of YAP1 immunohistochemistry has been highlighted in this setting. In other organs, loss of YAP1 expression can reflect YAP1 rearrangement or transcriptional repression, notably through RB1 inactivation. In this context, our objective was to re-evaluate the performance of YAP1 immunohistochemistry for the diagnosis of poroma and porocarcinoma.
METHODS AND RESULTS
The expression of the C-terminal part of the YAP1 protein was evaluated by immunohistochemistry in 543 cutaneous epithelial tumours, including 27 poromas, 14 porocarcinomas and 502 other cutaneous tumours. Tumours that showed a lack of expression of YAP1 were further investigated for Rb by immunohistochemistry and for fusion transcripts by real-time PCR (YAP1::MAML2 and YAP1::NUTM1). The absence of YAP1 expression was observed in 24 cases of poroma (89%), 10 porocarcinoma (72%), 162 Merkel cell carcinoma (98%), 14 squamous cell carcinoma (SCC) (15%), one trichoblastoma and one sebaceoma. Fusions of YAP1 were detected in only 16 cases of poroma (n = 66%), 10 porocarcinoma (71%) all lacking YAP1 expression, and in one sebaceoma. The loss of Rb expression was detected in all cases except one of YAP1-deficient SCC (n = 14), such tumours showing significant morphological overlap with porocarcinoma. In-vitro experiments in HaCat cells showed that RB1 knockdown resulted in repression of YAP1 protein expression.
CONCLUSION
In addition to gene fusion, we report that transcriptional repression of YAP1 can be observed in skin tumours with RB1 inactivation, including MCC and a subset of SCC.
Topics: Humans; Poroma; Sweat Gland Neoplasms; Eccrine Porocarcinoma; Skin Neoplasms; Transcription Factors; Carcinoma; Ubiquitin-Protein Ligases; Retinoblastoma Binding Proteins
PubMed: 36720791
DOI: 10.1111/his.14874 -
Clinical and Experimental Dermatology Dec 2019
Comparative Study
Topics: Aged; Biopsy; Dermoscopy; Diagnosis, Differential; Female; Humans; Poroma; Sensitivity and Specificity; Sweat Gland Neoplasms
PubMed: 30677158
DOI: 10.1111/ced.13913 -
Dermatology Practical & Conceptual Jul 2022
PubMed: 36159139
DOI: 10.5826/dpc.1203a135 -
Indian Journal of Dermatology 2023
PubMed: 38371545
DOI: 10.4103/ijd.ijd_585_22