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Hospital Medicine (London, England :... Apr 2002
Topics: Fluorodeoxyglucose F18; Gamma Cameras; Humans; Radiopharmaceuticals; Research; Tomography, Emission-Computed
PubMed: 11995267
DOI: 10.12968/hosp.2002.63.4.2035 -
PloS One 2018Imaging was conducted using an electron tracking-Compton camera (ETCC), which measures γ-rays with energies in the range of 200-900 keV from 95mTc. 95mTc was produced...
Imaging was conducted using an electron tracking-Compton camera (ETCC), which measures γ-rays with energies in the range of 200-900 keV from 95mTc. 95mTc was produced by the 95Mo(p, n)95mTc reaction on a 95Mo-enriched target. A method for recycling 95Mo-enriched molybdenum trioxide was employed, and the recycled yield of 95Mo was 70%-90%. Images were obtained with the gate of three energies. The results showed that the spatial resolution increases with increasing γ-ray energy, and suggested that the ETCC with high-energy γ-ray emitters such as 95mTc is useful for the medical imaging of deep tissue and organs in the human body.
Topics: Algorithms; Diagnostic Imaging; Electrons; Gamma Cameras; Gamma Rays; Humans; Molybdenum; Monte Carlo Method; Oxides; Phantoms, Imaging; Photons; Radioisotopes; Scattering, Radiation; Technetium
PubMed: 30532248
DOI: 10.1371/journal.pone.0208909 -
PET Clinics Jul 2018Recent advances in nuclear medicine instrumentation have led to the emergence of improved molecular imaging techniques to image breast cancer: dedicated gamma cameras... (Review)
Review
Recent advances in nuclear medicine instrumentation have led to the emergence of improved molecular imaging techniques to image breast cancer: dedicated gamma cameras using γ-emitting Tc-sestamibi and breast-specific PET cameras using F-fluorodeoxyglucose. This article focuses on the current role of such approaches in the clinical setting including diagnosis, assessing local extent of disease, monitoring response to therapy, and, for gamma camera imaging, possible supplemental screening in women with dense breasts. Barriers to clinical adoption and technologies and radiotracers under development are also discussed.
Topics: Breast; Breast Neoplasms; Female; Gamma Cameras; Humans; Positron-Emission Tomography; Radionuclide Imaging; Reproducibility of Results
PubMed: 30100076
DOI: 10.1016/j.cpet.2018.02.008 -
Radiological Physics and Technology Mar 2023
Topics: Gamma Cameras; Nuclear Medicine; Radionuclide Imaging; Physics; Positron-Emission Tomography
PubMed: 36534344
DOI: 10.1007/s12194-022-00693-z -
Microscopy (Oxford, England) Feb 2016Recent advances in single-particle electron cryo-microscopy (cryo-EM) were largely facilitated by the application of direct electron detection cameras. These cameras... (Review)
Review
Recent advances in single-particle electron cryo-microscopy (cryo-EM) were largely facilitated by the application of direct electron detection cameras. These cameras feature not only a significant improvement in detective quantum efficiency but also a high frame rate that enables images to be acquired as 'movies' made of stacks of many frames. In this review, we discuss how the applications of direct electron detection cameras in cryo-EM have changed the way the data are acquired.
Topics: Cryoelectron Microscopy; Electrons; Imaging, Three-Dimensional
PubMed: 26546989
DOI: 10.1093/jmicro/dfv355 -
Trends in Pharmacological Sciences Sep 2010Small-animal positron emission tomography (PET) is a preclinical imaging method that uses pharmacologically or biochemically active compounds labelled with short-lived... (Review)
Review
Small-animal positron emission tomography (PET) is a preclinical imaging method that uses pharmacologically or biochemically active compounds labelled with short-lived positron-emitting radionuclides. This non-invasive nuclear medicine technique requiring animal-dedicated PET cameras (microPET) enables in vivo measurements of physiological processes, biochemical pathways and neurotransmitters. It therefore has a role in studying the pathophysiology and pharmacology of the brain. Moreover, there is increasing evidence that microPET imaging can accelerate drug development by revealing early information regarding biomarkers of pathophysiology or drug mechanisms and cerebral bioavailability. This review presents the potential contribution of microPET in basic neuropharmacology, illustrating its recent contributions and methodological specificities as well as highlighting its limits and constraints. In addition, we aim to encourage the use of PET molecular imaging in basic neuropharmacology to complement other preclinical approaches.
Topics: Animals; Brain; Drug Delivery Systems; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 20599282
DOI: 10.1016/j.tips.2010.06.002 -
Radiologic Clinics of North America Sep 2001Positron emission tomography scanning has evolved over the past 40 years from a tool used predominantly for research to a valued clinical imaging modality. Current PET... (Review)
Review
Positron emission tomography scanning has evolved over the past 40 years from a tool used predominantly for research to a valued clinical imaging modality. Current PET scanners must perform high-quality whole-body PET and brain PET. There are several levels of PET devices from the dedicated, high-end scanners down to the hybrid PET-SPECT systems offering varying levels of performance. The next generation of PET scanners will most likely involve the use of new scintillating materials. There is also a growing interest in dedicated devices for specific applications, such as high-resolution scanners for imaging small animals.
Topics: Animals; Gamma Cameras; Humans; Tomography, Emission-Computed; Tomography, X-Ray Computed
PubMed: 11587061
DOI: 10.1016/s0033-8389(05)70320-1 -
Biophysical Journal Jul 2022Modern electron-multiplying charge-coupled device (EMCCD) and scientific complementary metal-oxide semiconductor (sCMOS) cameras read out fluorescence data with...
Modern electron-multiplying charge-coupled device (EMCCD) and scientific complementary metal-oxide semiconductor (sCMOS) cameras read out fluorescence data with single-molecule sensitivity at thousands of frames per second. Exploiting these capabilities in full requires data evaluation in real time. The direct camera-read-out tool presented here allows access to the data while the camera is recording. This provides simplified and accurate alignment procedures for total internal reflection fluorescence microscopy (TIRFM) and single-plane illumination microscopy (SPIM), and simplifies and accelerates fluorescence experiments. The tool handles a range of widely used EMCCD and sCMOS cameras and uses imaging fluorescence correlation spectroscopy for its evaluation. It is easily extendable to other camera models and other techniques and is a base for automated TIRFM and SPIM data acquisition.
Topics: Electrons; Equipment Design; Microscopy, Fluorescence; Semiconductors; Spectrometry, Fluorescence
PubMed: 35672950
DOI: 10.1016/j.bpj.2022.06.009 -
Journal of Nuclear Medicine : Official... Jan 1986A single-slice positron camera has been developed with good spatial resolution and high count rate capability. The camera uses a hexagonal arrangement of six...
A single-slice positron camera has been developed with good spatial resolution and high count rate capability. The camera uses a hexagonal arrangement of six position-sensitive NaI(Tl) detectors. The count rate capability of NaI(Tl) was extended to 800k cps through the use of pulse shortening. In order to keep the detectors stationary, an iterative reconstruction algorithm was modified which ignores the missing data in the gaps between the six detectors and gives artifact-free images. The spatial resolution, as determined from the image of point sources in air, is 6.5 mm full width at half maximum. We have also imaged a brain phantom and dog hearts.
Topics: Animals; Dogs; Heart; Humans; Models, Structural; Radioisotopes; Rubidium; Software; Technology, Radiologic; Tomography, Emission-Computed
PubMed: 3484522
DOI: No ID Found -
Indian Journal of Nuclear Medicine :... 2024Artifacts in nuclear medicine imaging are not uncommon. We are aware of some of these, for which we follow necessary protocols to avoid them. However, there are some...
Artifacts in nuclear medicine imaging are not uncommon. We are aware of some of these, for which we follow necessary protocols to avoid them. However, there are some unusual and unavoidable artifacts that we come across in daily imaging, which may be of concern and need to be detected and corrected on time. Hence, sharing a few such unusual artifacts we encountered while performing routine studies on positron emission tomography-computed tomography and gamma cameras, evaluating the cause and possible precautions.
PubMed: 38817718
DOI: 10.4103/ijnm.ijnm_105_23