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Retinal Cases & Brief Reports 2016To describe a case of posterior uveitis with retinal vasculitis related to Ehrlichia exposure.
PURPOSE
To describe a case of posterior uveitis with retinal vasculitis related to Ehrlichia exposure.
PATIENTS AND METHODS
Single case report of a 68-year-old woman with posterior uveitis, steroid-induced glaucoma, and retinal holes.
RESULTS
Ehrlichia titers were elevated 4-fold (1:256; normal <1:64) with an otherwise normal laboratory workup. The patient's cystoid macular edema responded to sub-Tenon's triamcinolone and oral doxycycline.
CONCLUSION
To our knowledge, this is the first case of posterior uveitis associated with Ehrlichia reported in humans.
Topics: Ehrlichia; Ehrlichiosis; Eye Infections, Bacterial; Female; Fluorescein Angiography; Fundus Oculi; Humans; Posterior Eye Segment; Tomography, Optical Coherence; Uveitis, Posterior; Visual Acuity
PubMed: 26352324
DOI: 10.1097/ICB.0000000000000192 -
The British Journal of Ophthalmology Dec 1946
Topics: Endophthalmitis; Eye; Humans; Sarcoidosis; Uveitis; Uveitis, Posterior
PubMed: 18170286
DOI: 10.1136/bjo.30.12.724 -
Ophthalmology Aug 2012
Topics: Adult; Choroid Diseases; Eye Infections; Female; Fluorescein Angiography; Humans; Male; Middle Aged; Retinal Diseases; Uveitis, Posterior; Visual Acuity
PubMed: 22858026
DOI: 10.1016/j.ophtha.2012.04.014 -
Japanese Journal of Ophthalmology Jul 2012To determine the infectious causes of posterior uveitis (PU) and panuveitis (panU) in Thailand.
PURPOSE
To determine the infectious causes of posterior uveitis (PU) and panuveitis (panU) in Thailand.
METHODS
We investigated the infectious causes of uveitis involving the posterior segment of the eye by using real-time polymerase chain reaction (PCR) for cytomegalovirus (CMV), herpes simplex virus (HSV-1, HSV-2), varicella zoster virus and Toxoplasma gondii (T. gondii) DNA in intraocular samples of 80 human immunodeficiency virus (HIV)-negative patients. Additionally, in 61 patients, we performed Goldmann-Witmer coefficient (GWC) analysis for T. gondii.
RESULTS
Twenty-four (30 %) patients with PU and/or panU had a positive PCR result. Overall, CMV was the most frequently identified organism. While CMV was the most common cause of uveitis in the patients on immunosuppressive medications for nonocular disorders, HSV was the most common cause of posterior and panuveitis in the patients not receiving such medication. In 38 PU patients, CMV was the most common detected pathogen. In 42 panU patients, CMV and HSV-2 were the most frequently identified pathogens. Out of 61 paired samples analyzed for T. gondii by GWC analysis, only 1 revealed a positive result. There was no difference in PCR results between aqueous humor and vitreous samples.
CONCLUSIONS
CMV was the most frequently identified infectious organism in posterior and panuveitis of HIV-1-negative Thai patients. Aqueous humor and vitreous samples showed similar diagnostic values in PCR analysis.
Topics: Adolescent; Adult; Aged; Antibodies, Protozoan; Aqueous Humor; Child; Cytomegalovirus Infections; DNA, Protozoan; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Eye Infections, Viral; Female; Herpes Simplex; Herpes Zoster Ophthalmicus; Humans; Male; Middle Aged; Panuveitis; Real-Time Polymerase Chain Reaction; Thailand; Toxoplasmosis, Ocular; Uveitis, Posterior; Vitreous Body; Young Adult
PubMed: 22539102
DOI: 10.1007/s10384-012-0144-5 -
Acta Ophthalmologica Aug 2014To assess tuberculous uveitis in Chinese patients. (Observational Study)
Observational Study
PURPOSE
To assess tuberculous uveitis in Chinese patients.
METHODS
The hospital-based observational case series study included patients who attended a third-referral hospital and presented with chronic and recurrent uveitis without primarily detected aetiology. The patients underwent the tuberculin skin test (TST) and/or interferon gamma release test (IGRA). Patients with positive test results received standard antituberculous therapy. Patients who responded to the therapy and did not show recurrence of uveitis in the follow-up period were diagnosed as tuberculous uveitis and formed the study group. The remaining patients were diagnosed as non-tuberculous uveitis and formed the control group. The clinical characteristics were compared between both groups.
RESULTS
The study group with tuberculous uveitis included 46 patients and the non-tuberculous group 38 patients. Multifocal choroiditis [n = 9 (20%) versus n = 1(3%); p = 0.04] and retinal vasculitis [n = 25(54%) versus 8 = (21.1%); p = 0.002] were significantly more common in the study group. Of 25 patients with retinal vasculitis in the study group, 11 patients (44%) additionally showed choroiditis lesions, compared with only one (13%) of eight patients in the control group (p = 0.01). In multivariate regression analysis, multifocal choroiditis [odds ratio (OR): 32.1], choroidal granuloma (OR: 21.4) and retinal vasculitis (OR: 11.2) were independent predictors of tubercular uveitis.
CONCLUSIONS
About 50% of a group of 84 patients with primarily unexplained chronic posterior uveitis had tuberculosis and showed multifocal choroiditis, choroidal granuloma and retinal vasculitis. These features had a high predictive value for the diagnosis of tuberculous uveitis. Tuberculosis is an important part in the differential diagnosis of unexplained uveitis.
Topics: Adult; Aged; Antitubercular Agents; China; Choroiditis; Female; Follow-Up Studies; Humans; Interferon-gamma Release Tests; Male; Middle Aged; Multifocal Choroiditis; Prevalence; Retinal Vasculitis; Tuberculin Test; Tuberculosis, Ocular; Uveitis, Posterior
PubMed: 24479692
DOI: 10.1111/aos.12351 -
International Ophthalmology Clinics 2000
Review
Topics: Glucocorticoids; Humans; Immunosuppressive Agents; Uveitis, Posterior
PubMed: 10791263
DOI: 10.1097/00004397-200004000-00012 -
Romanian Journal of Ophthalmology 2015We present the case of a 61-year-old patient without previous ophthalmic or general history, who developed unilateral posterior pole granuloma and was diagnosed with...
We present the case of a 61-year-old patient without previous ophthalmic or general history, who developed unilateral posterior pole granuloma and was diagnosed with posterior uveitis most likely due to a systemic Toxocara canis infection. Clinical examination and ancillary investigations showed elements that were also consistent with wet ARMD, but laboratory tests and successful use of oral anti-helminthic and corticosteroid therapy in decreasing the macular lesion and improving visual acuity, confirmed the diagnosis of posterior uveitis.
Topics: Administration, Ophthalmic; Angiography; Animals; Anthelmintics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Ceftriaxone; Diagnosis, Differential; Drug Therapy, Combination; Female; Fluorescein; Fluorescent Dyes; Humans; Middle Aged; Tomography, Optical Coherence; Toxocara canis; Toxocariasis; Treatment Outcome; Uveitis, Posterior; Visual Acuity; Wet Macular Degeneration
PubMed: 27373119
DOI: No ID Found -
Ophthalmic Surgery, Lasers & Imaging... Mar 2021Neovascularization is a sight-threatening, uncommon complication of posterior uveitis that often goes undetected until persistent clinical findings appear, or in light...
BACKGROUND AND OBJECTIVE
Neovascularization is a sight-threatening, uncommon complication of posterior uveitis that often goes undetected until persistent clinical findings appear, or in light of treatment failure. This could be attributed to the relative similarity of activity signs in inflammatory neovascular membranes (NVM) and active posterior uveitis. The purpose of the present study is to recognize imaging features that distinguish uveitic neovascularization from active uveitis using swept-source optical coherence tomography angiography (SS-OCTA).
PATIENTS AND METHODS
Cross-sectional study. Patients with posterior uveitis with visual acuity (VA) decrease and at least one of the following findings were assessed by SS-OCTA: retinal thickening, subretinal or intraretinal fluid, and retinal hyperreflective areas. The change of VA and imaging features after treatment with anti-vascular endothelial growth factor (VEGF) therapy were analyzed in cases with inflammatory NVM.
RESULTS
Forty-five eyes of 40 patients were evaluated. Twenty-four eyes (53.3%) showed signs of activity, of which eight (33.3%) presented inflammatory NVM. Imaging features that differentiate inflammatory neovascularization from active posterior uveitis included: vitreous cellularity ( = .003), outer retinal infiltration ( = .08), choroidal thickness ( = .003), posterior shadowing ( = .013), subretinal fluid ( = .04), and neovascular network ( ≤ .001). According to NVM characteristics by OCTA, multiple anastomoses and peripheral arcades were visualized at baseline in 85.7% of cases. Mean pre-operative best-corrected VA of inflammatory NVM was 20/150 (logMAR: 0.88 ± 0.60) with significant improvement to 20/40 (logMAR: 0.32 ± 0.22) after anti-VEGF treatment ( = .027).
CONCLUSIONS
SS-OCTA achieves the distinction of inflammatory NVM from active posterior uveitis through specific imaging features. Inflammatory neovascularization presents a suitable response after anti-VEGF therapy. .
Topics: Angiogenesis Inhibitors; Choroidal Neovascularization; Cross-Sectional Studies; Fluorescein Angiography; Humans; Retrospective Studies; Tomography, Optical Coherence; Uveitis, Posterior; Visual Acuity
PubMed: 34038687
DOI: 10.3928/23258160-20210302-03 -
International Ophthalmology Clinics 1990
Review
Topics: Eye Diseases; Fluorescein Angiography; Humans; Uveitis, Posterior
PubMed: 2228479
DOI: 10.1097/00004397-199030040-00021 -
Journal Francais D'ophtalmologie Apr 2011The role of streptococcal infections in the development of uveitis remains uncertain. Here we describe a series of patients with suspected poststreptococcal uveitis.
PURPOSE
The role of streptococcal infections in the development of uveitis remains uncertain. Here we describe a series of patients with suspected poststreptococcal uveitis.
OBSERVATION
Four retrospective cases were collected (two males and two females). All patients had a sore throat or an episode of pyrexia 2 to 10 weeks before the onset of uveitis and elevated antistreptolysin-O titer (ASOT); no other cause of uveitis was found. Uveitis was bilateral in all the cases and recurrent in only one. In two patients, inflammation was limited to the anterior segment. One patient had intermediate uveitis. One patient had posterior uveitis with multiple white-dot lesions as well as macular and optic disc swelling. The two cases with anterior uveitis were treated only topically and the two others received a short course of systemic steroids. No systemic antibiotics were given.
CONCLUSIONS
These cases suggest that uveitis could be a manifestation of poststreptococcal syndrome and have a good prognosis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antistreptolysin; Female; Fluorescein Angiography; Humans; Male; Methylprednisolone; Ophthalmic Solutions; Ophthalmoscopy; Pharyngitis; Prednisolone; Retrospective Studies; Streptococcal Infections; Tomography, Optical Coherence; Uveitis, Anterior; Uveitis, Intermediate; Uveitis, Posterior; Young Adult
PubMed: 21444125
DOI: 10.1016/j.jfo.2010.11.002