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The Journal of International Medical... Dec 2021To evaluate the antiviral activity of the oral disinfectant povidone-iodine (PVP-I) against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) .
OBJECTIVE
To evaluate the antiviral activity of the oral disinfectant povidone-iodine (PVP-I) against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) .
METHODS
The cytotoxic effects of PVP-I were determined in Vero and Calu-3 cell lines using that by Cell Counting Kit-8 assay. Viral load in the cell culture medium above infected cells was quantitated using real-time polymerase chain reaction. The cytopathic effect (CPE) and viral infective rate were observed by immunofluorescence microscopy.
RESULTS
PVP-I at a concentration >0.5 mg/ml in contact with SARS-CoV-2 for 30 s, 1 min, 2 min and 5 min showed up to 99% viral inhibition. For testing, upon exposure for 1 min, PVP-I showed a virucidal effect. PVP-I had no cytotoxic effects at the range of concentrations tested (0.125-1 mg/ml; CC > 2.75 mM) in Vero and Calu-3 cells.
CONCLUSION
These results demonstrate that the ideal contact time was 1 min and the optimal concentration was 1 mg/ml, which provides an experimental basis for the use of oral disinfectants in dental hospitals.
Topics: COVID-19; Cell Line; Humans; Povidone-Iodine; RNA, Viral; SARS-CoV-2
PubMed: 34914884
DOI: 10.1177/03000605211063695 -
British Journal of Nursing (Mark Allen... Mar 2003Infection is of primary concern to those practitioners treating burns patients, as it is one of the primary complications associated with acute wounds and particularly... (Review)
Review
Infection is of primary concern to those practitioners treating burns patients, as it is one of the primary complications associated with acute wounds and particularly with superficial partial-thickness burns. In the fight to reduce the risks, many practitioners deploy common antimicrobials agents prophylactically to help reduce risks, e.g. povidone-iodine. This review will examine the evidence to support this practice. The deployment of povidone-iodine in wound care is highly controversial, with questions being raised concerning not only the effectiveness of the product but also its safety and effect on wound healing. The use of povidone-iodine has been investigated both in vitro and in vivo, resulting in conflicting and often contradictory results. Of the work completed to date, researchers have failed to identify or control for extraneous variables which makes it difficult to compare and interpret research findings. The potential benefits or harm that the use of povidone-iodine may elicit in acute wounds is yet to be established.
Topics: Anti-Infective Agents, Local; Burns; Humans; Povidone-Iodine; Trauma Severity Indices
PubMed: 12682580
DOI: 10.12968/bjon.2003.12.Sup1.11250 -
Biomaterials Science Aug 2019Biomaterial-associated infections caused by bacterial contamination and the subsequent formation of biofilms on the surfaces are challenges faced by our healthcare...
Biomaterial-associated infections caused by bacterial contamination and the subsequent formation of biofilms on the surfaces are challenges faced by our healthcare system. In this work, povidone-iodine-functionalized fluorinated copolymers with stable antibacterial, antibiofilm, and antifouling activities were designed and prepared by a two-step synthesis. First, a series of poly(hexafluorobutyl methacrylate-co-N-vinyl-2-pyrrolidone), i.e., P(HFBMA-NVP), were synthesized by radical copolymerization at different feed ratios to acquire water insoluble and antifouling copolymers. At the second step, the NVP segments in the copolymer were complexed with iodine to obtain the objective antibacterial and antifouling copolymer P(HFBMA-NVP)-I. The chemical and physical characteristics of the copolymers were investigated using H NMR, FTIR, XPS, EDX, UV-Vis, SEM, TEM, elemental analysis, and contact angle measurement. P(HFBMA-NVP)-I exhibited excellent antibacterial activity against both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus), as well as good biocompatibility towards human hepatocyte cells (L02) and Caenorhabditis elegans. Using the electrospinning or spraying technique, P(HFBMA-NVP)-I was coated on polystyrene slides, medical stainless steel sheets, and cotton fabric, allowing the surfaces to have stable antibacterial and antibiofilm activities against pathogenic bacteria and antifouling capability against foulants and blood, and exhibit excellent self-cleaning properties.
Topics: Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Biofouling; Cell Line; Escherichia coli; Halogenation; Humans; Hydrophobic and Hydrophilic Interactions; Materials Testing; Povidone-Iodine; Staphylococcus aureus
PubMed: 31215915
DOI: 10.1039/c9bm00583h -
Journal of Cataract and Refractive... Jul 2017
Topics: Anti-Bacterial Agents; Antisepsis; Povidone-Iodine
PubMed: 28823457
DOI: 10.1016/j.jcrs.2017.05.026 -
JAMA Apr 1989
Topics: Animals; Dogs; Humans; Peritoneal Lavage; Povidone; Povidone-Iodine; Wound Infection
PubMed: 2926923
DOI: 10.1001/jama.261.13.1881 -
Burns : Journal of the International... Mar 2001Skin preparation burns associated with chemical agents are uncommon. They occur most frequently in patients placed in the lithotomic position undergoing gynaecologic or...
Skin preparation burns associated with chemical agents are uncommon. They occur most frequently in patients placed in the lithotomic position undergoing gynaecologic or urologic operations, the burn being on the buttocks, and in those undergoing orthopaedic operations, the burn being on the extremities and under a tourniquet. The basic mechanism involves irritation coupled with maceration and pressure. If the betadine solution has not been allowed to dry and has been trapped under the body of the patient in a pooled dependent position, such as the buttocks or under a tourniquet, the solution may irritate the skin and result in a skin burn. The irritation coupled with pressure leads to a situation analogous to that seen in the development of an acute accelerated decubitus ulcer; irritation, maceration, friction and pressure compounding each other to result in a skin burn or superficial ulcer in the skin. Our experience with three illustrative patients who presented with various burns following exposure to povidone-iodine (betadine) is described below.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents, Local; Burns, Chemical; Follow-Up Studies; Humans; Male; Middle Aged; Povidone-Iodine; Risk Assessment; Surgical Procedures, Operative; Tourniquets
PubMed: 11226660
DOI: 10.1016/s0305-4179(00)00081-4 -
The American Journal of Emergency... Nov 1987
Review
Topics: Emergencies; Humans; Povidone; Povidone-Iodine; Wound Infection
PubMed: 3311063
DOI: 10.1016/0735-6757(87)90199-9 -
British Dental Journal Sep 2020
Topics: Iodine; Povidone-Iodine
PubMed: 32917988
DOI: 10.1038/s41415-020-2127-0 -
British Journal of Community Nursing Jun 2003With the proliferation of antibiotic and antiseptic resistant strains of bacteria around the world, attention is increasingly being focused on more 'traditional' methods... (Review)
Review
With the proliferation of antibiotic and antiseptic resistant strains of bacteria around the world, attention is increasingly being focused on more 'traditional' methods of combating and preventing wound infections. This article examines the research literature pertaining to the use of povidone-iodine, a form of iodine commonly used for skin cleansing, as a prophylaxis or treatment for wound infection. The literature is discussed as it relates to the ideal characteristics of an antiseptic for use on wounds proposed by König et al (1997) and Liptak (1997). On the basis of available research, it appears that povidone-iodine should be promoted by nurses and other healthcare professionals involved in wound care as a means of preventing and treating infection in a range of acute and chronic wounds.
Topics: Administration, Topical; Anti-Infective Agents, Local; Humans; Povidone-Iodine; Wound Infection
PubMed: 12819593
DOI: 10.12968/bjcn.2003.8.Sup2.11555 -
The Cleft Palate-craniofacial Journal :... May 2019Establishing continuity of the cutaneous roll is critical to cleft lip repair. Unfortunately, this landmark can be difficult to appreciate depending on the patient's...
BACKGROUND
Establishing continuity of the cutaneous roll is critical to cleft lip repair. Unfortunately, this landmark can be difficult to appreciate depending on the patient's skin tone, surgical lighting, or preexisting scar.
SOLUTION
When applied to the lip, dilute povidone-iodine solution beads off the cutaneous roll and dry vermilion, clearly defining these structures.
WHAT WE DO
We use dilute povidone-iodine solution not only to prep the lip but to delineate landmarks critical to cleft lip repair.
Topics: Cicatrix; Cleft Lip; Humans; Povidone-Iodine; Plastic Surgery Procedures; Surgical Flaps
PubMed: 30304949
DOI: 10.1177/1055665618805883