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Veterinary Research Communications Jun 2022Industrial chemical solutions are widely used as a method to disinfection of aquaculture water and environments. The aim of the present study was to evaluate the...
Industrial chemical solutions are widely used as a method to disinfection of aquaculture water and environments. The aim of the present study was to evaluate the toxicity effect of Betadine (10% solution of povidone-iodine) as a disinfectant solution on the survival and gill tissue of Oranda goldfish (Carassius auratus). For these purposes, 225 fingerling Oranda goldfish with an average weight 5 ± 0.67 g were divided into 15 groups with 3 replications. Fish were exposed to series of concentrations (0, 10, 20, 40, 60, 80, 90, 100, 120, 140, 160, 180, 200, 220 and 240 mg/L) of Betadine for 96 h. The mortality of fish and the samples of gill were observed at 6, 12, 18, 24, 48, 72 and 96 h after exposure. The results of the present study showed that the half-life of Betadine was less than 24 h and mortality were not record after 24 h. The highest mortality rate was at 240 mg/L, and LC 24 h of Betadine was 158.800 mg/L. Histopathological results showed that lethal concentrations of Betadine lead to hyperemia, hypertrophy, hyperplasia and adhesion of secondary lamellar of the gill. Moreover, fish that were exposed to these concentrations displayed clinical signs such as anxiety, darkening of the skin. Overall results showed that Betadine have short half-life in the aquatic environment and are toxic to fish at very high concentrations, therefore it can be considered as practically non-toxic and useful for disinfection of the aquatic environment.
Topics: Animals; Aquaculture; Gills; Goldfish; Povidone-Iodine; Survival Rate
PubMed: 34816339
DOI: 10.1007/s11259-021-09862-8 -
American Journal of Infection Control Apr 2020In a randomized, nonblinded, placebo-controlled trial, a single application of a 10% povidone iodine preparation significantly reduced nasal methicillin-resistant... (Randomized Controlled Trial)
Randomized Controlled Trial
In a randomized, nonblinded, placebo-controlled trial, a single application of a 10% povidone iodine preparation significantly reduced nasal methicillin-resistant Staphylococcus aureus at 1 and 6 hours after application, but suppression was not sustained at 12 or 24 hours. Twice-daily treatment for 5 days did not reduce nasal methicillin-resistant S aureus measured 12 hours postdosing in comparison to controls. These results suggest that single preoperative applications of povidone iodine will be effective for short-term suppression of S aureus during the perioperative period.
Topics: Carrier State; Humans; Methicillin-Resistant Staphylococcus aureus; Nose; Povidone-Iodine
PubMed: 31735591
DOI: 10.1016/j.ajic.2019.09.014 -
The Journal of Urology Jan 2023
Randomized Controlled Trial
Effectiveness of Intrarectal Povidone-iodine Cleansing Plus Formalin Disinfection of the Needle Tip in Decreasing Infectious Complications After Transrectal Prostate Biopsy: A Randomized Controlled Trial. Reply.
Topics: Humans; Male; Povidone-Iodine; Prostate; Formaldehyde; Biopsy; Disinfection
PubMed: 36484447
DOI: 10.1097/JU.0000000000002995 -
The Australian and New Zealand Journal... Oct 1997The use of intraperitoneal povidone iodine as an agent for peritoneal lavage in colorectal surgery is controversial. Although it possesses a wide range of antimicrobial... (Review)
Review
BACKGROUND
The use of intraperitoneal povidone iodine as an agent for peritoneal lavage in colorectal surgery is controversial. Although it possesses a wide range of antimicrobial activity and is rapidly lethal to dissociated colorectal cancer cells in vitro, concern about its potential toxicity remains.
METHODS
Two cases of sclerosing encapsulating peritonitis (SEP) following elective colorectal surgery are presented. In each case the peritoneal cavity was lavaged with an aqueous povidone iodine solution. The surgical literature on the intraperitoneal use of povidone iodine is reviewed.
RESULTS
Significant morbidity resulted from the postoperative development of SEP in both of our patients. In one patient an ileo-anal pouch could not be fashioned following an initial colectomy, and in the second patient a small-bowel obstruction required a laparotomy and a period of intravenous nutrition before an oral diet could be tolerated.
CONCLUSION
The use of povidone iodine for peritoneal lavage in colorectal surgery is to be cautioned against in concentrations of > 1%.
Topics: Adult; Aged; Animals; Anti-Infective Agents, Local; Female; Humans; Intestinal Obstruction; Intestines; Male; Peritoneal Lavage; Peritonitis; Povidone-Iodine; Rats; Sclerosis
PubMed: 9322732
DOI: 10.1111/j.1445-2197.1997.tb07126.x -
Indian Pediatrics Sep 2023
Topics: Humans; Povidone-Iodine; Acute Disease; Hypothyroidism; Eating
PubMed: 37705278
DOI: No ID Found -
European Spine Journal : Official... Jun 2006Intra-operative incidental contamination of surgical wounds is not rare. Povidone-iodine solution can be used to disinfect surgical wounds. Although povidone-iodine is a... (Randomized Controlled Trial)
Randomized Controlled Trial
UNLABELLED
Intra-operative incidental contamination of surgical wounds is not rare. Povidone-iodine solution can be used to disinfect surgical wounds. Although povidone-iodine is a good broad-spectrum disinfecting agent, it has occasionally been reported to have a negative effect on wound healing and bone union. Therefore, its safety in a spinal surgery is unclear. A prospective, single-blinded, randomized study was accordingly conducted to evaluate the safety of povidone-iodine solution in spinal surgeries. Ascertained herein was the effect of wound irrigation with diluted povidone-iodine solution on wound healing, infection rate, fusion status and clinical outcome of spinal surgeries.
MATERIALS AND METHODS
From January 2002 to August 2003, 244 consecutive cases undergoing primary instrumented lumbosacral posterolateral fusion due to degenerative spinal disorder with segmental instability had been collected and randomly divided into two groups: the study group (120 cases, 212 fusion levels) and the control group (124 cases, 223 fusion levels). Excluded were those patients with a prior spinal surgery, spinal trauma, malignant tumor, infectious spondylitis, rheumatoid arthritis, ankylosing spondylitis, metabolic bone disease, skeletal immaturity or with an immunosuppressive treatment. In the former group, wounds were irrigated with 0.35% povidone-iodine solution followed by normal saline solution just before the bone-grafting and instrumentation procedure. However, only with normal saline solution in the latter. All the operations were done by the same surgeon with a standard technique. All the patients were treated in the same postoperative fashion as well. Later on, wound healing, infection rate, spinal bone fusion and clinical outcome were evaluated in both groups.
RESULTS
A significant improvement of back and leg pain scores, modified Japanese Orthopedic Association function scores (JOA) and ambulatory capacity have been observed in both groups. One hundred and seven patients in the study group and one hundred and nine in the control group achieved solid union. There was no infection in the study group but six deep infections in the control group. Wound dehiscence was noted in one group 1 and two group 2 patients. A subsequent statistical analysis revealed higher infection rate in the control group (P<0.05), but no significant difference in fusion rate, wound healing, improvement of pain score, function score and ambulatory capacity between the two groups.
CONCLUSION
Diluted povidone-iodine solution can be used safely in spinal surgeries, and it will not influence wound healing, bone union and clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Female; Humans; Male; Middle Aged; Povidone-Iodine; Prospective Studies; Single-Blind Method; Spinal Diseases; Spinal Fusion; Surgical Wound Infection; Therapeutic Irrigation
PubMed: 16133077
DOI: 10.1007/s00586-005-0975-6 -
Neurourology and Urodynamics Feb 2021To determine if daily povidone-iodine (PI) bladder irrigation in neurogenic lower urinary tract dysfunction (NLUTD) patients doing clean intermittent catheterization...
AIMS
To determine if daily povidone-iodine (PI) bladder irrigation in neurogenic lower urinary tract dysfunction (NLUTD) patients doing clean intermittent catheterization (CIC) can reduce the rate of symptomatic urinary tract infections (UTIs), emergency department (ED) visit for UTIs, and hospitalization for UTIs.
METHODS
We prospectively reviewed the records of patients with NLUTD on CIC who had recurrent symptomatic UTIs and who were placed on daily intravesical instillations of PI. This trial was conducted from January 2014 to January 2020 on 119 patients.
RESULTS
After using daily PI bladder irrigation, the rate of symptomatic UTIs was reduced by 99.2% (incidence rate ratio [IRR]: 0.008, 95% confidence interval [CI]: 0.001-0.059; p < .001), the rate of ED visits was reduced by 99.2%% (IRR: 0.008, 95% CI: 0.001-0.059; p < .001), and the rate of inpatient hospitalizations for UTI was reduced by 99.9% (IRR: 0.0008, 95% CI: 0.0002-0.0035; p < .001). There was also a significant decrease in multidrug resistance in UTI organisms with the use of PI bladder instillation.
CONCLUSIONS
Daily intravesical PI instillation is a well-tolerated approach to prevent UTIs and related ED visits and hospitalizations in NLUTD patients doing CIC.
Topics: Adolescent; Adult; Female; Humans; Incidence; Intermittent Urethral Catheterization; Male; Middle Aged; Povidone-Iodine; Prospective Studies; Therapeutic Irrigation; Urinary Bladder, Neurogenic; Urinary Tract Infections; Young Adult
PubMed: 33476092
DOI: 10.1002/nau.24607 -
The British Journal of Ophthalmology Feb 2011Povidone-iodine (PI) is commonly used as a preoperative disinfectant; however, it has been shown to be cytotoxic. The present study was performed to investigate the...
BACKGROUND/AIMS
Povidone-iodine (PI) is commonly used as a preoperative disinfectant; however, it has been shown to be cytotoxic. The present study was performed to investigate the mechanism by which PI causes cell death.
METHODS
Primary human corneal fibroblasts (HCF) and a human corneal epithelial cell line (HCEC) were treated with 0.1-5% PI for 1 min. Cell morphology and growth were examined by phase-contrast microscopy and genomic DNA quantification. Cellular enzyme activities were detected by water-soluble tetrazolium salt (WST-1) and calcein-acetoxymethylester staining, whereas membrane integrity was determined by a membrane-impermeable dye. The cell fixation effect of PI was assayed by analysis of genomic DNA integrity and resistance to ionic detergent SDS lysis. The interleukin-8 (IL-8) secretion after adding interleukin-1ß (IL-1b) or lipopolysaccharide (LPS) was determined by ELISA.
RESULTS
PI treatment inhibited HCF and HCEC cell growth without changing cellular morphology; however, cells became resistant to SDS lysis. The mitochondrial dehydrogenase and intracellular esterase activities as well as cell membrane integrity were abolished by PI treatment. Genomic DNA integrity from PI-treated groups was similar to that from alcohol-fixed groups. IL-1b- and LPS-induced IL-8 secretion was abolished by PI treatment.
CONCLUSIONS
Where PI concentration is sufficient to cause cell death, this occurs through fixation rather than necrosis in cultured human corneal stromal and epithelial cell.
Topics: Anti-Infective Agents, Local; Cell Death; Cells, Cultured; Cornea; Fibroblasts; Humans; Povidone-Iodine
PubMed: 21036788
DOI: 10.1136/bjo.2010.189407 -
Ear, Nose, & Throat Journal Mar 2021
Topics: Administration, Topical; Adolescent; Chronic Disease; Dermatitis, Contact; Erythema; Humans; Male; Mastoidectomy; Medical Illustration; Otitis Media, Suppurative; Postoperative Complications; Povidone-Iodine
PubMed: 31547715
DOI: 10.1177/0145561319876908 -
The Journal of Contemporary Dental... Apr 2023To evaluate the effects of two preprocedural mouthrinses, hydrogen peroxide (HO) and povidone iodine (PI) on the surface characteristics and mechanical properties of...
AIM
To evaluate the effects of two preprocedural mouthrinses, hydrogen peroxide (HO) and povidone iodine (PI) on the surface characteristics and mechanical properties of nickel-titanium (NiTi) and stainless steel (SS) orthodontic archwires.
MATERIALS AND METHODS
Five wire specimens were used, each (0.016" NiTi, 0.016" SS wires, 0.016 × 0.022" NiTi and 0.016 × 0.022" SS wires) specimen was cut into 30 mm lengths and immersed in 9% of artificial saliva and 91% of two preprocedural mouthrinse solutions: 1.5% hydrogen peroxide mouthwash, 0.2% povidone-iodine mouthwash, and distilled water (control group) for 90 minutes and incubated at 37°C. The wire specimens were then subjected to a three-point bending test for mechanical testing and viewed under a scanning electron microscope (SEM) to evaluate their surface characteristics. The collected data were analyzed using one-way analysis of variance (ANOVA) and Bonferroni post hoc test.
RESULTS
The results showed a significant increase in the flexural modulus (E) of Nitinol wires in povidone-iodine gargle ( < 0.05) and a significant increase in the E of stainless steel wires in hydrogen peroxide mouthwash ( < 0.05). Analysis using SEM showed varying qualitative surface changes in the form of corrosion, voids, and ridges on the wires after exposure to both the mouthwashes.
CONCLUSION
Though there were significant changes in the flexural modulus of archwires for both the mouthwashes, hydrogen peroxide did not show a significant difference in the E of wires at most of the deflection intervals when compared with the other two solutions, hence, could be used in orthodontic patients as an effective preprocedural mouthrinse.
CLINICAL SIGNIFICANCE
Preprocedural mouthrinses can cause surface irregularities on the wires which in turn lead to an increase in friction at the bracket-wire interface, thereby disrupting effective tooth movement and extending the orthodontic treatment time.
Topics: Humans; Mouthwashes; Hydrogen Peroxide; Povidone-Iodine; Orthodontic Wires; Stainless Steel; Dental Alloys; Titanium; Materials Testing; Surface Properties
PubMed: 37469261
DOI: 10.5005/jp-journals-10024-3484