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Journal of Pediatric Endocrinology &... Jul 2000The new methods which are currently available have provided substantial help in performing the differential diagnosis of CPP, especially in detecting very early... (Review)
Review
The new methods which are currently available have provided substantial help in performing the differential diagnosis of CPP, especially in detecting very early modifications of gonadotropin secretion. Nocturnal sampling is not a practical tool and generates discomfort for patients, and daytime samples do not yet have sufficient sensitivity; thus, determination of LH levels after GnRH stimulation is the most important test. We emphasize that the use of the GnRH agonist test improves the discrimination of the endocrine investigation, making it easier to differentiate CPP from other conditions, such as thelarche. Determination of sex steroids is necessary, but its use in isolation is not recommended.
Topics: Brain Diseases; Child; Child, Preschool; Endocrine Glands; Gonadal Steroid Hormones; Gonadotropins; Humans; Puberty, Precocious
PubMed: 10969913
DOI: 10.1515/jpem.2000.13.s1.709 -
Nihon Rinsho. Japanese Journal of... Apr 2006
Review
Topics: Anastrozole; Aromatase Inhibitors; Female; Fibrous Dysplasia, Polyostotic; Gonadotropins, Pituitary; Humans; Leuprolide; Male; Nitriles; Prognosis; Puberty, Precocious; Surgical Procedures, Operative; Triazoles
PubMed: 16689312
DOI: No ID Found -
Pediatric Annals Jan 2018Premature thelarche is a benign condition that affects young girls and may be interpreted as a sign of central precocious puberty (CPP). Parental concern is common when... (Review)
Review
Premature thelarche is a benign condition that affects young girls and may be interpreted as a sign of central precocious puberty (CPP). Parental concern is common when breast development is noted in a young girl. It is important to differentiate premature thelarche from CPP, as the latter is a more serious disorder that may affect final adult height and menarcheal age, and may have psychological implications as well. Distinguishing between the two conditions clinically may help the patients avoid unnecessary testing. Pediatricians can play a pivotal role by providing reassurance to families and helping alleviate parental anxiety. This article reviews the clinical presentation of premature thelarche, its usual course, and implications. [Pediatr Ann. 2018;47(1):e12-e15.].
Topics: Breast; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Infant; Puberty; Puberty, Precocious
PubMed: 29323691
DOI: 10.3928/19382359-20171214-01 -
Journal of Clinical Research in... Nov 2021To evaluate the clinical features and etiology of precocious puberty (PP) in Chinese boys.
OBJECTIVE
To evaluate the clinical features and etiology of precocious puberty (PP) in Chinese boys.
METHODS
In this study, data from boys who were referred for evaluation of PP from 2015 to 2020 at a tertiary hospital in Northern China were retrospectively analyzed.
RESULTS
Eighty-two boys were diagnosed with PP from 2015 to 2020. Sixty-two patients (75.6%) were diagnosed with central PP (CPP), and twenty patients (24.4%) were diagnosed with peripheral PP (PPP). In the CPP group, forty-nine cases were classified as idiopathic CPP, and thirteen patients had pathogenic CPP. The top three causes of PPP were congenital adrenal hyperplasia, germ cell tumors and familial male-limited PP.
CONCLUSION
The etiology of PP in males is diverse. The majority of CPP cases in Chinese boys are idiopathic rather than organic.
Topics: Child; Child, Preschool; China; Humans; Male; Puberty, Precocious; Retrospective Studies
PubMed: 34013711
DOI: 10.4274/jcrpe.galenos.2021.2021.0033 -
The New England Journal of Medicine Apr 1985
Topics: Child; Female; Humans; Ketoconazole; Male; Puberty, Precocious
PubMed: 3982458
DOI: 10.1056/NEJM198504183121611 -
Medicina Clinica Dec 2022
Topics: Male; Humans; Puberty, Precocious; Triptorelin Pamoate; Ketoconazole; Gonadotropin-Releasing Hormone
PubMed: 36049976
DOI: 10.1016/j.medcli.2022.08.007 -
Hormone Research 1994This paper will deal with the psychologic correlates of abnormal puberty and the implications for assessment and treatment. The main areas of adolescent behavior,... (Review)
Review
This paper will deal with the psychologic correlates of abnormal puberty and the implications for assessment and treatment. The main areas of adolescent behavior, equally relevant to the child who undergoes normal or abnormal puberty, are psychosexual development, psychopathology and mental functioning in terms of level of intelligence and cognitive strengths and weaknesses. Regarding psychosexual development, the important findings are that adolescents with precocious puberty tend to be somewhat earlier in starting their adolescent sex life, though they still remain within the normal range of current standards. The reports on psychopathology in children with precocious puberty on a short-term or long-term basis are based on clinical case reports and systematic studies and suggest that a history of precocious puberty may carry with it an increased risk of psychopathology. IQ and school achievement are typically not negatively affected in precocious puberty; in fact, there is a suggestion of the opposite. It may be that there is an advantage in intellectual development associated with early pubertal maturation, which may be temporary rather than long-term.
Topics: Adolescent; Female; Humans; Longitudinal Studies; Male; Mental Disorders; Mental Processes; Psychosexual Development; Puberty, Precocious; Social Behavior
PubMed: 8088701
DOI: 10.1159/000183956 -
Nihon Rinsho. Japanese Journal of... 1982
Review
Topics: Brain Neoplasms; Child; Child, Preschool; Choriocarcinoma; Chorionic Gonadotropin; Female; Humans; Hypothyroidism; Male; Medroxyprogesterone; Pregnancy; Puberty, Precocious
PubMed: 6754989
DOI: No ID Found -
Indian Journal of Pediatrics Jan 2006Growth in precocious puberty is a subject of concern to families and clinicians alike. The definition of precocious puberty and the role of obesity in the age of onset...
Growth in precocious puberty is a subject of concern to families and clinicians alike. The definition of precocious puberty and the role of obesity in the age of onset have also been areas of debate since the Lawson Wilkins Society recommended a lowering of the age of onset of precocious puberty in US girls. An understanding of growth patterns in normal children with earlier or later onset of puberty and the variable rate of progression between individuals with central precocious puberty as well as the imprecision in available height prediction methods are important in assessing height outcomes in this condition. In the absence of randomised controlled trials in this area, only qualified conclusions about the effectiveness of interventions can be drawn. In general, it appears that height outcome is not compromised in untreated slowly progressive variants of central precocious puberty. In rapidly progressing central precocious puberty in girls, gonadotrophin releasing hormone agonists (GnRH agonists) appear to increase final height by about 5 cm in girls treated before the age of eight, but there is no height benefit in those treated after eight years. Scanly data is available to assess treatment effects in boys. GnRH agonists appear to be relatively safe. The decision to treat central precocious puberty should take into account rate of progression of pubertal changes as well as biochemical markers and may need to address other factors (for example psychosocial and behavioural issues) as well as height outcome.
Topics: Child; Child Development; Female; Growth; Growth Disorders; Humans; Male; Obesity; Puberty, Precocious
PubMed: 16444068
DOI: 10.1007/BF02758267 -
European Journal of Endocrinology Dec 2008In this review several aspects of gonadotrophin releasing hormone agonists (GnRHa) treatment in central precocious puberty (CPP) are highlighted. These include issues of... (Review)
Review
In this review several aspects of gonadotrophin releasing hormone agonists (GnRHa) treatment in central precocious puberty (CPP) are highlighted. These include issues of the definition of precocity, assessment of CPP and thelarche variants. Indications for treatment with GnRH agonists are discussed, not only in CPP but also in children with other reasons to suppress central activation, e.g. adopted or developmental retardation. Finally, outcome data are summarized, both on growth and psychosocial parameters.
Topics: Body Height; Breast; Child; Child Development; Female; Gonadotropin-Releasing Hormone; Growth; Humans; Psychology; Puberty, Precocious; Social Change; Terminology as Topic; Treatment Outcome
PubMed: 19064674
DOI: 10.1530/EJE-08-0814