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The Journal of Clinical Endocrinology... Feb 1999
Review
Topics: Age Determination by Skeleton; Child; Female; Gonadotropin-Releasing Hormone; Humans; Male; Puberty, Precocious
PubMed: 10022393
DOI: 10.1210/jcem.84.2.5533 -
Pediatrics in Review Jul 2015
Topics: Age of Onset; Diagnosis, Differential; Female; Gonadotropin-Releasing Hormone; Humans; Male; Puberty, Precocious
PubMed: 26133309
DOI: 10.1542/pir.36-7-319 -
Lancet (London, England) Jul 1986
Topics: Bone and Bones; Child; Female; Humans; Male; Pituitary Hormone-Releasing Hormones; Puberty, Precocious; Sexual Maturation
PubMed: 2873384
DOI: No ID Found -
Journal of Pediatric Rehabilitation... 2020Children with spina bifida are at greater risk of developing central precocious puberty (CPP) compared to others. Therefore, early recognition and timely referral for... (Review)
Review
Children with spina bifida are at greater risk of developing central precocious puberty (CPP) compared to others. Therefore, early recognition and timely referral for further evaluation by a pediatric endocrinologist allows appropriate management that reduces the impact of CPP. This article discusses the diagnosis and management of CPP in children with spina bifida. This guideline was developed for SB Transition Healthcare Guidelines from the 2018 Spina Bifida Association's Fourth Edition of the Guidelines for the Care of People with Spina Bifida.
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Practice Guidelines as Topic; Puberty, Precocious; Spinal Dysraphism; Young Adult
PubMed: 33325409
DOI: 10.3233/PRM-200728 -
Journal of Pediatric Health Care :... 1991
Topics: Child; Female; Humans; Male; Nurse Practitioners; Pediatric Nursing; Puberty, Precocious
PubMed: 1920003
DOI: 10.1016/0891-5245(91)90082-2 -
Pediatric Endocrinology Reviews : PER Sep 2015The intent of the current manuscript is to review the cases of central precocious puberty (CPP) in early childhood following traumatic brain injury (TBI). SEARCH OF THE... (Meta-Analysis)
Meta-Analysis Review
AIMS OF THE REVIEW
The intent of the current manuscript is to review the cases of central precocious puberty (CPP) in early childhood following traumatic brain injury (TBI). SEARCH OF THE LITERATURE: The MEDLINE database was accessed through PubMed in April 2015. Results were not restricted to the date and language of the articles. For the first search we utilized MeSH terms "precocious puberty" in conjunction with "traumatic brain injury" and with "endocrine consequences". Reference lists were reviewed and relevant papers were also consulted to find additional studies and data. In selected cases the corresponding author was contacted by email.
RESULTS
In our systematic review, only a few case reports or small case series have highlighted a link between TBI and hypothalamic-pituitary hormone abnormalities. Fourteen reported children were females and 8 were males. The majority of patients reported had severe TBI, assessed by Glasgow Coma Scale or structural injury (skull fractures, intracranial hemorrhage or cerebral injury) reported on computerized tomography or magnetic resonance imaging scans. The pathogenic mechanism of precocious puberty has not yet been determined. An increased pressure on the hypothalamic-pituitary area with loss of normal childhood hypothalamic inhibition of pituitary gonadotropins could be one of the factors responsible for CPP after TBI.
CONCLUSIONS
The current review highlights the importance of close clinical follow-up to evaluate the rate of linear growth and pubertal development after TBI. Although, precocious puberty appears to be rare after TBI, prevalence should ideally be assessed by longitudinal follow-up of a large population. Therefore, further multicenter and multidisciplinary studies are required to explore in detail the true incidence and the possible mechanisms of CPP after TBI. Because precocious puberty can be detected on clinical assessment during childhood, a pragmatic approach would be for family physicians to monitor growth and development in children after TBI. Inasmuch as precocity is mediated through the hypothalamic-pituitary pathways, use of LH-RH analogue therapy should be effective in arresting pubertal progression.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Puberty, Precocious
PubMed: 26540762
DOI: No ID Found -
BMC Pediatrics Sep 2023The purpose of this study is to explore the related factors of precocious puberty in children.
BACKGROUND
The purpose of this study is to explore the related factors of precocious puberty in children.
METHODS
1239 children who underwent physical examination in our hospital from January 2020 to December 2022 were analyzed, including 198 precocious children and 1041 normal children. According to the age of 198 precocious children and 1041 normal children, 205 normal children were selected, and the remaining 836 normal children were excluded. They were divided into precocious group and normal group. The general data of the two groups were recorded. Logistic regression was used to analyze the influencing factors of precocious puberty in children.
RESULTS
There were statistically significant differences (P < 0.05) between the two groups in sex, bone age, daily exercise time, E2, FSH, LH, leptin, mother's menarche time, living environment, consumption of nutritional supplements, consumption of foods containing pigments and preservatives, consumption of high-protein foods, and sleeping time. The multifactor logistic regression analysis shows that the risk factors of children's precocious puberty included gender (female), bone age (> 10 years old), and daily exercise time (< 0.9 h), E2 (≥ 66.00pmol/L), FSH (≥ 6.00U/L), LH (≥ 3.50U/L), leptin (≥ 8.00 µ G/L), mother's menarche time (< 12 years old), living environment (chemical industry zone), consumption of nutritional supplements (often), consumption of high-protein food (often), and sleep time (< 10 h).
CONCLUSION
In conclusion, children's gender, bone age, exercise habits, E2, FSH, LH, leptin, mother's menarche time, living environment, eating habits, sleep time and other factors are closely related to precocious puberty in children. Reminding parents to actively prevent related factors in clinical work is helpful to prevent the occurrence of precocious puberty in children.
Topics: Humans; Child; Female; Leptin; Puberty, Precocious; Risk Factors; Dietary Supplements; Follicle Stimulating Hormone
PubMed: 37697362
DOI: 10.1186/s12887-023-04265-x -
BMC Endocrine Disorders Oct 2023The pineal lesion affecting melatonin is a rare cause of central precocious puberty by decreasing the inhibition of hypothalamic-pituitary-gonadal axis. Germ cell tumor... (Review)
Review
BACKGROUND
The pineal lesion affecting melatonin is a rare cause of central precocious puberty by decreasing the inhibition of hypothalamic-pituitary-gonadal axis. Germ cell tumor secreting human chorionic gonadotropin is a rare cause of peripheral puberty.
CASE PRESENTATION
A 5.8-year-old male presented facial hair and phallic growth, deepened voice, and accelerated growth velocity for 6 months. The elevated human chorionic gonadotropin level with undetectable gonadotropin levels indicated peripheral precocious puberty. Brain imaging revealed a pineal mass and further pathology indicated the diagnosis of teratoma. During chemoradiotherapy with operation, the elevated human chorionic gonadotropin level reduced to normal range, while the levels of gonadotropins and testosterone increased. Subsequently, progressing precocious puberty was arrested with gonadotrophin-releasing hormone analog therapy. Previous cases of transition from peripheral precocious puberty to central precocious puberty were reviewed. The transitions were caused by the suddenly reduced feedback inhibition of sex steroid hormones on gonadotropin releasing hormone and gonadotropins.
CONCLUSIONS
For patients with human chorionic gonadotropin-secreting tumors, gonadotropin levels increase prior to sex steroid decrease, seems a sign of melatonin-related central PP related to melatonin.
Topics: Child, Preschool; Humans; Male; Chorionic Gonadotropin; Gonadal Steroid Hormones; Gonadotropin-Releasing Hormone; Melatonin; Neoplasms, Germ Cell and Embryonal; Puberty, Precocious
PubMed: 37884982
DOI: 10.1186/s12902-023-01494-0 -
Archivos Argentinos de Pediatria Jun 2023Introduction. Puberty is manifested initially by the onset of secondary sexual characteristics as a result of hormonal changes that progressively lead to complete sexual...
Introduction. Puberty is manifested initially by the onset of secondary sexual characteristics as a result of hormonal changes that progressively lead to complete sexual maturity. In Argentina and worldwide, the lockdown resulting from the SARS-CoV-2 pandemic may have interfered in the onset and timing of pubertal development. Objective. To describe the perception of pediatric endocrinologists in Argentina regarding consultations for suspected precocious and/or rapidly progressive puberty during the pandemic. Materials and methods. Descriptive, observational, cross-sectional study. Anonymous survey among pediatric endocrinologists members of the Sociedad Argentina de Pediatría and/or the Asociación de Endocrinología Pediátrica Argentina administered in December 2021. Results. Out of 144 pediatric endocrinologists, 83 completed the survey (rate of response: 58%). All of them considered that consultation for precocious or early puberty increased, either in terms of early thelarche (84%), early pubarche (26%), and/or precocious puberty (95%). Ninety-nine percent agreed that this has occurred to a greater extent in girls. All survey respondents also consider that the diagnosis of central precocious puberty has increased. In total, 96.4% of respondents consider that the number of patients treated with GnRH analogs has increased. Conclusion. Our results about the perception of pediatric endocrinologists are consistent with data published in other regions on the increase in the diagnosis of precocious puberty during the COVID-19 pandemic. We underscore the need to develop national registries of central precocious puberty, and to disseminate the evidence for a timely detection and management.
Topics: Child; Female; Humans; Puberty, Precocious; Pandemics; COVID-19; Cross-Sectional Studies; Endocrinologists; SARS-CoV-2; Communicable Disease Control
PubMed: 36892314
DOI: 10.5546/aap.2022-02767.eng -
Endokrynologia Polska 2008Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of... (Review)
Review
Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopathic or associated with hypothalamic hamartoma, brain neoplasms, numerous non-cancerous disorders of the central nervous system and treatment of peripheral precocious puberty. The goal of the initial assessment of children is to exclude the presence of all these organic disorders. The diagnosis should include detailed anamnesis and clinical examination, measurement of pituitary and sex hormones, assessment of bone age, and imaging of the hypothalamus, pituitary gland, abdomen, pelvis and gonads. The treatment of choice are gonadotropin-releasing hormone agonists. In this paper, we review the current views on the etiopathogenesis, clinical presentation, diagnosis and management of central precocious puberty.
Topics: Brain Diseases, Metabolic; Child; Female; Gonadotropin-Releasing Hormone; Humans; Hypothalamus; Male; Puberty, Precocious
PubMed: 19347819
DOI: No ID Found