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Nederlands Tijdschrift Voor Geneeskunde Nov 1956
Topics: Prednisone
PubMed: 13387904
DOI: No ID Found -
Drug Design, Development and Therapy 2016The introduction of modified-release (MR) prednisone adds a drug with encouraging potential to the armamentarium of the rheumatologist. In particular, for patients... (Review)
Review
The introduction of modified-release (MR) prednisone adds a drug with encouraging potential to the armamentarium of the rheumatologist. In particular, for patients experiencing a reduced quality of life due to prolonged morning stiffness, it is a promising therapeutic approach. Two clinical trials and one open-label observational study investigated the effectiveness of MR prednisone in reducing rheumatoid arthritis-related morning stiffness for both new and current users of corticosteroids. The efficacy and safety of MR prednisone use in rheumatoid arthritis patients are reviewed in this article. This includes pivotal trials as well as pathophysiological considerations and clinical implications.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Prednisone
PubMed: 27022244
DOI: 10.2147/DDDT.S87792 -
The Practitioner Jan 1958
Topics: Prednisolone; Prednisone
PubMed: 13494328
DOI: No ID Found -
The New England Journal of Medicine Oct 1969
Topics: Humans; Hydrocortisone; Pituitary-Adrenal System; Prednisone
PubMed: 5824731
DOI: 10.1056/nejm196910302811817 -
The Medical Letter on Drugs and... Nov 2012
Topics: Chemistry, Pharmaceutical; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Approval; Humans; Prednisone; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration
PubMed: 23183387
DOI: No ID Found -
MMW Fortschritte Der Medizin Apr 2021
Review
Topics: Adolescent; Child; Child Health; Cluster Headache; Female; Humans; Prednisone; Pregnancy
PubMed: 33783782
DOI: 10.1007/s15006-021-9772-3 -
Prednisone for chronic active liver disease: pharmacokinetics, including conversion to prednisolone.Gastroenterology May 1977To determine the effect of impaired liver function on conversion of prednisone to prednisolone, and to investigate the relationship of this to responses to treatment... (Comparative Study)
Comparative Study
To determine the effect of impaired liver function on conversion of prednisone to prednisolone, and to investigate the relationship of this to responses to treatment with prednisone, we measured serum prednisone and prednisolone by radioimmunoassay after 10 mg of prednisone was given by vein to 10 healthy volunteers, 6 untreated patients with severe chronic active liver disease (CALD), 10 patients with prednisone-induced remission of CALD, and 3 patients with CALD deteriorating despite treatment with prednisone. Prednisone disappearance was comparable in all groups and substantial values for serum prednisolone appeared in all groups within 0.3 hr. Minor differences between the groups included lower than normal serum prednisolone in severe CALD and treatment failure; a higher percentage of nonprotein bound prednisolone in such patients; and an association between earlier treatment with prednisone and an increased disappearance rate of prednisolone. We conclude that no major defect of prednisone metabolism occurs in CALD and that failure of this condition to respond to therapy with prednisone is caused by other factors.
Topics: Adult; Chronic Disease; Female; Humans; Kinetics; Liver Diseases; Male; Middle Aged; Prednisolone; Prednisone
PubMed: 849821
DOI: No ID Found -
Archives of Dermatology Oct 1977
Topics: Alopecia Areata; Humans; Prednisone
PubMed: 911178
DOI: 10.1001/archderm.1977.01640100135032 -
Nederlands Tijdschrift Voor Geneeskunde May 2019A vulnerable elderly man with prednisone-induced delirium Background Delirium always has an underlying cause, for example, medication. This article describes the case of...
A vulnerable elderly man with prednisone-induced delirium Background Delirium always has an underlying cause, for example, medication. This article describes the case of a man with severe delirium caused by prednisone. Case description A 91-year-old vulnerable man developed severe delirium with agitation, verbal and physical aggression and visual hallucinations 3 days after starting treatment with low-dose prednisone. The delirium disappeared completely after prednisone was stopped. The delirium led to a long hospital stay of 36 days, weight loss of 10 kg due to undernourishment and extension of home care on discharge. Conclusion This case illustrates that delirium is always lurking around the corner in patients with multiple vulnerabilities. The provoking factor can be slight, for example 15 or 5 mg of prednisone. So be careful when starting prednisone in vulnerable elderly patients.
Topics: Aged, 80 and over; Delirium; Glucocorticoids; Hallucinations; Humans; Male; Prednisone
PubMed: 31120224
DOI: No ID Found -
The New England Journal of Medicine Nov 1989
Topics: Humans; Muscles; Muscular Dystrophies; Prednisone
PubMed: 2811967
DOI: 10.1056/NEJM198911233212117