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Muscle & Nerve Dec 2004Glucocorticoid use may provide short-term functional improvement in boys with Duchenne muscular dystrophy (DMD). We report functional and histopathologic changes...
Glucocorticoid use may provide short-term functional improvement in boys with Duchenne muscular dystrophy (DMD). We report functional and histopathologic changes following a 4-month course of daily oral prednisone in a canine model of DMD, termed golden retriever muscular dystrophy (GRMD). Muscle extension forces in GRMD dogs treated daily with 1 and 2 mg/kg prednisone measured 2.349 +/- 0.92 and 3.486 +/- 0.67 N/kg, respectively, compared to 1.927 +/- 0.63 N/kg in untreated GRMD controls (p < 0.05 for 2 mg/kg group); GRMD muscle flexion forces measured 0.435 +/- 0.13 and 0.303 +/- 0.08 N/kg, respectively, compared to 0.527 +/- 0.01 N/kg in untreated GRMD controls (p < 0.05 for both groups). Although cranial sartorius hypertrophy and tibiotarsal joint angles also tended to improve, myofiber calcification increased and fetal myosin expression decreased following prednisone. Thus, functional data indicate benefit but histopathologic changes following prednisone treatment in GRMD suggest possible deleterious consequences.
Topics: Animals; Dogs; Isometric Contraction; Muscle, Skeletal; Muscular Dystrophy, Animal; Prednisone
PubMed: 15468337
DOI: 10.1002/mus.20154 -
Praxis 2017
Randomized Controlled Trial
Topics: Aged; Antibodies, Monoclonal, Humanized; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Giant Cell Arteritis; Humans; Male; Middle Aged; Prednisone; Remission Induction
PubMed: 29088969
DOI: 10.1024/1661-8157/a002823 -
Nursing Nov 1990
Topics: Asthma; Humans; Prednisone
PubMed: 2267065
DOI: 10.1097/00152193-199011000-00039 -
Journal of Pharmacokinetics and... Apr 1976
Comparative Study
Topics: Adult; Biological Availability; Humans; Male; Prednisone; Tablets
PubMed: 950588
DOI: 10.1007/BF01086151 -
Acta Physiologica Et Pharmacologica... Dec 1956
Topics: Ambulatory Care Facilities; Humans; Prednisone
PubMed: 13402508
DOI: No ID Found -
Journal of Pharmaceutical Sciences Jan 1975In a clinical study involving 22 normal adult volunteers, the bioavailability and pharmacokinetics of prednisone tablets with varying dissolution rates were evaluated....
In a clinical study involving 22 normal adult volunteers, the bioavailability and pharmacokinetics of prednisone tablets with varying dissolution rates were evaluated. Serum levels were measured by a radioimmunoassay for prednisolone. Absorption rate constants and serum half-lives are presented. Substantial serum levels of prednisolone were attained quite rapidly (within 0.5 hr). The observed serum levels were statistically analyzed and fitted to the one-compartment open model with first-order absorption and elimination. A qualitative correlation between the in vitro dissolution rate and the calculated initial absorption rate constants was found. However, the in vitro dissolution rates were not predictive of the overall bioavailability of the prednisone tablets tested in terms of peak concentration and area under the serum concentration-time curve.
Topics: Biological Availability; Computers; Female; Half-Life; Humans; Kinetics; Male; Prednisone; Radioimmunoassay
PubMed: 1133681
DOI: 10.1002/jps.2600640122 -
Biopharmaceutics & Drug Disposition 1985
Topics: Animals; Chromatography, High Pressure Liquid; Female; Infusions, Parenteral; Kinetics; Models, Biological; Prednisolone; Prednisone; Rabbits
PubMed: 4041559
DOI: 10.1002/bdd.2510060308 -
ORL; Journal For Oto-rhino-laryngology... 197776 patients with severe Bell's palsy were treated for a short period with high doses of prednisone (60 mg for 4 days and from the 5th day on the dose was reduced every...
76 patients with severe Bell's palsy were treated for a short period with high doses of prednisone (60 mg for 4 days and from the 5th day on the dose was reduced every day by 5 mg). The treatment was started within the 1st week of onset. The onset, the course and the recovery of the paralysis were carefully evaluated. The facial recovery is presented in such way as to make possible comparison with other series of recovery after Bell's palsy.
Topics: Adolescent; Adult; Aged; Child; Drug Administration Schedule; Facial Paralysis; Female; Humans; Male; Middle Aged; Prednisone
PubMed: 565905
DOI: 10.1159/000275366 -
Journal of Ovarian Research Apr 2023Prednisone is one of the most used synthetic glucocorticoids during pregnancy. Epidemiological investigations suggested that prenatal prednisone therapy could affect...
BACKGROUND
Prednisone is one of the most used synthetic glucocorticoids during pregnancy. Epidemiological investigations suggested that prenatal prednisone therapy could affect fetal development, but systematic studies on its effects on ovarian development and the "toxic effect window" remained scarce.
METHODS
In this study, by simulating clinical application characteristics, Kunming mice were given prednisone by oral gavage with different doses (0.25 or 1.0 mg/kg·d) or at different time gestational days (GD) (GD0-9, GD10-18, or GD0-18). Blood and ovaries of fetal mice were collected on GD18, and the serum estradiol level and the related function indexes of ovarian granulosa cells and oocytes were detected.
RESULTS
Compared with the control group, prenatal prednisone exposure (PPE) induced pathological injury and enhanced cell proliferation in fetal mice ovary. Furthermore, the expression of steroid synthesis functional genes in pre-granulosa cells, the oocyte function markers, and developmentally related genes was enhanced with different doses or at different time of PPE. The Hippo signaling was activated in the fetal ovary of PPE groups. The above changes were most significant in the low or high-dose and full-term PPE groups.
CONCLUSION
PPE caused various cell developmental toxicity in the fetal ovary, especially in the low or high-dose, full-term exposure groups. The potential mechanism might be related to the activation of the Hippo signaling pathway.
Topics: Mice; Pregnancy; Female; Animals; Estradiol; Prednisone; Ovary; Oocytes
PubMed: 37038227
DOI: 10.1186/s13048-023-01148-8 -
American Journal of Diseases of... Aug 1978Children with acquired glomerular disease were divided into two groups: Group 1 patients received short-term daily or long-term alternate-day prednisone (up to 2.7...
Children with acquired glomerular disease were divided into two groups: Group 1 patients received short-term daily or long-term alternate-day prednisone (up to 2.7 mg/kg/48 hr); group 2 patients received no corticosteroids. Height, bone mineral content (BMC), and bone density were evaluated in the two groups and compared to those of 800 sex- and age-matched controls; BMC and bone density were assessed by the photon absorption technique. Significant demineralization was present in 18 of 25 prednisone-treated and none of the 17 nonprednisone-treated patients (P less than .001). Group 1 patients were 5.3 +/- 0.7% shorter than controls, while group 2 patients were only 1.9 +/- .8% shorter (P less than .02). Height velocity was 2.6 +/- 0.8 cm/yr in group 1 and 5.1 +/- 0.8 cm/yr in group 2 patients (P less than .05). When prednisone therapy was discontinued, six patients had an increase in height and BMC toward normal values. This study suggests that BMC and height velocity are correlated. Both appear to be influenced by alternate-day prednisone therapy rather than by glomerular disease per se.
Topics: Adolescent; Body Height; Bone and Bones; Child; Child, Preschool; Female; Growth; Humans; Kidney Diseases; Kidney Glomerulus; Male; Minerals; Prednisone
PubMed: 685891
DOI: 10.1001/archpedi.1978.02120330040010