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The Journal of Pediatrics Jan 1996We reviewed our experience with the use of oral corticosteroid therapy in treating hemangiomas of infants to determine the optimal effective dose. (Clinical Trial)
Clinical Trial
OBJECTIVE
We reviewed our experience with the use of oral corticosteroid therapy in treating hemangiomas of infants to determine the optimal effective dose.
STUDY DESIGN
During a 24-year period, 60 infants with hemangiomas were treated with an initial dose of either 3 or 5 mg/kg per day of orally administered prednisone for a period ranging from 6 to 12 weeks. Involution of the hemangioma and re-growth. were monitored.
RESULTS
Overall, excellent and rapid results were achieved in 68% of infants and good results occurred in 25%. In 7% treatment was deemed to have failed. Forty-seven of 60 patients received one course of therapy, 8 received 2 courses, and 5 required 3 courses. An initial dose of 5 mg/kg per day oral prednisone therapy was more effective than 3 mg/kg per day. Side effects were not serious and resolved after discontinuation of therapy.
CONCLUSIONS
High oral doses of corticosteroids (5 mg/kg per day prednisone) provide an effective, rapid, and safe modality of treatment of hemangiomas of infants. We recommend that treatment continue for 6 to 8 weeks, and in more severe cases for as long as 12 weeks.
Topics: Administration, Oral; Drug Administration Schedule; Female; Hemangioma; Humans; Infant; Infant, Newborn; Male; Prednisone; Treatment Outcome
PubMed: 8551406
DOI: 10.1016/s0022-3476(96)70446-8 -
Acta Medica Philippina 1955
Topics: Biomedical Research; Prednisone; Skin Diseases
PubMed: 13361823
DOI: No ID Found -
The New England Journal of Medicine Jan 1974
Topics: Adult; Aged; Cholinesterase Inhibitors; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Prednisone
PubMed: 4808454
DOI: 10.1056/NEJM197401102900204 -
Clinical Pharmacokinetics 1979Among the corticosteroids, prednisone is the most commonly used in the treatment of chronic active liver disease. However, its pharmacokinetics have only recently been... (Review)
Review
Among the corticosteroids, prednisone is the most commonly used in the treatment of chronic active liver disease. However, its pharmacokinetics have only recently been investigated. Prednisone is effectively absorbed and converted to its active therapeutic derivative, prednisolone, in healthy volunteers and in patients with liver disease; the bioavailability of oral prednisone approximates 100% of an intravenous dose and is comparable after administration of either prednisone or prednisolone. Patients with liver disease and hypoalbuminaemia are more likely to suffer major side effects of prednisone as a consequence of decreased protein binding and delayed clearance of prednisolone. Dosage in such patients should be reduced in accordance with serum albumin concentration.
Topics: Blood Proteins; Chronic Disease; Humans; Liver Diseases; Prednisolone; Prednisone; Protein Binding
PubMed: 383357
DOI: 10.2165/00003088-197904030-00005 -
Acta Allergologica 1957
Topics: Asthma; Guinea Pigs; Prednisone
PubMed: 13468940
DOI: 10.1111/j.1398-9995.1957.tb03026.x -
Soins; La Revue de Reference Infirmiere Aug 1982
Topics: Administration, Oral; Humans; Prednisone
PubMed: 6924410
DOI: No ID Found -
The Annals of Pharmacotherapy Nov 2011
Topics: Adrenal Cortex Hormones; Humans; Male; Middle Aged; Panic Disorder; Prednisone
PubMed: 22009994
DOI: 10.1345/aph.1Q387 -
The Journal of Pediatrics Feb 1979Sequential hematologic studies were performed in four infants with malignant osteopetrosis who received prednisone. Prednisone therapy resulted in decreased liver and...
Sequential hematologic studies were performed in four infants with malignant osteopetrosis who received prednisone. Prednisone therapy resulted in decreased liver and spleen size, decreased numbers of circulating immature blood cells, and increased hemoglobin concentration and platelet counts in all infants. The quantity and quality of hematopoietic tissue in bone marrow biopsies improved during prednisone therapy but showed no significant improvement without therapy. Sequential indium 111 chloride scans in one infant showed increased uptake in long bones and pelvis and decreased uptake in liver and spleen during therapy. We conclude that prednisone therapy of infantile osteopetrosis results in increased bone marrow hematopoiesis and decreased extramedullary hematopoiesis.
Topics: Hematopoiesis; Humans; Infant; Liver; Male; Osteopetrosis; Prednisone; Spleen
PubMed: 762608
DOI: 10.1016/s0022-3476(79)80825-2 -
La Semana Medica Jan 1961
Topics: Leukemia; Prednisone
PubMed: 13743106
DOI: No ID Found -
Journal of Pharmaceutical and... Apr 2003We investigate the effect of stirring conditions on the dissolution of United States Pharmacopoeial Convention (USP) prednisone calibrator tablets. The experiments are...
We investigate the effect of stirring conditions on the dissolution of United States Pharmacopoeial Convention (USP) prednisone calibrator tablets. The experiments are performed in an automated USP-II dissolution test apparatus. For this study we use a special paddle-propeller, which can be changed from an ordinary paddle to either a pulling or pushing propeller by changing the angle of the paddle blades. According to the dissolution curves obtained we find that the fastest dissolution, and hence best stirring at a certain stirring frequency, is obtained when the blades of the paddle-propeller is about +30 degrees. This setting corresponds to a pushing, downward flow in the centre of the vessel. We show that the shape of the dissolution curves is similar to that expected from a mix of two different fractions of particles, provided that the stirring is sufficiently intense: one fraction, approximately 60 wt.%, with small particles, and one fraction with large particles. The weight of a large particle is about 100-250 times that of a small. We derive a mathematical expression, based on the cube root law, for the dissolution curves. The expression is fitted to the experimental dissolution curves to investigate the variation of key parameters with stirring and temperature.
Topics: Calibration; Chemistry, Pharmaceutical; Particle Size; Prednisone; Solubility; Tablets; Technology, Pharmaceutical
PubMed: 12667929
DOI: 10.1016/s0731-7085(02)00732-x