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Lancet (London, England) May 1966
Topics: Adult; Aged; Emergencies; Female; Graves Disease; Humans; Prednisone; Prognosis
PubMed: 4161099
DOI: No ID Found -
[Therapy of bronchial asthma by mucus drainage and hyaluronidase-hydrocortisone-prednisone aerosol].Orvosi Hetilap Feb 1958
Topics: Aerosols; Asthma; Body Fluids; Drainage; Humans; Hyaluronoglucosaminidase; Hydrocortisone; Mucus; Prednisone
PubMed: 13542009
DOI: No ID Found -
Journal of Pharmaceutical Sciences Jun 2007Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms...
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisone are reviewed. Due to insufficient data prednisone cannot be definitively classified according to the current Biopharmaceutics Classification System (BCS) criteria as both the solubility and the permeability of prednisone are on the borderline of the present criteria of BCS Class I. Prednisone's therapeutic indications and therapeutic index, pharmacokinetics and the possibility of excipient interactions were also taken into consideration. Available evidence indicates that a biowaiver for IR solid oral dosage forms formulated with the excipients tabulated in this article would be unlikely to expose patients to undue risks.
Topics: Administration, Oral; Excipients; Humans; Permeability; Prednisone; Solubility; Therapeutic Equivalency
PubMed: 17387693
DOI: 10.1002/jps.20817 -
The Journal of Heart Transplantation 1990The standard therapy for acute cardiac allograft rejection is intravenous methylprednisolone, usually in doses of about 3 gm per treatment. Treatment is undertaken in...
The standard therapy for acute cardiac allograft rejection is intravenous methylprednisolone, usually in doses of about 3 gm per treatment. Treatment is undertaken in most cases solely on the basis of a histologic diagnosis of rejection, irrespective of hemodynamic status. To reduce total corticosteroid dose and administer therapy in an outpatient environment, low-dose oral prednisone protocols were developed for the treatment of acute rejection in the absence of important hemodynamic compromise. A high-dose oral prednisone pulse (2 gm total for the average 75 kg male patient) was used in the first month. Thereafter a series of low-dose oral prednisone pulses were used (range, 0.5 to 1.0 gm total for the average 75 kg male patient). Of 85 transplant recipients at risk, 188 rejection episodes were treated over a 1477 total patient-months of follow-up. The high-dose oral pulse resulted in successful therapy (no subsequent therapy required) in 34 of 65 treatments (52%). The low-dose oral pulse was successful in treating 80 of 123 treatments (65%). This approach to acute rejection did not appear to adversely affect patient or graft outcome based on progression of stable to unstable hemodynamics, survival (84% and 82%, 1- and 2-year actuarial survival, respectively), or left ventricular ejection fraction (0.56 +/- 0.09 and 0.54 +/- 0.08, at 1 and 2 years, respectively). There did not appear to be discriminating factors that determined the therapeutic outcome, other than the higher failure rate within 1 month of transplant. We conclude that acute allograft rejection in the absence of important hemodynamic compromise responds to lower-than-conventional doses of corticosteroids in the majority of cases.
Topics: Administration, Oral; Clinical Protocols; Drug Administration Schedule; Graft Rejection; Heart Transplantation; Hemodynamics; Humans; Male; Prednisone
PubMed: 2355285
DOI: No ID Found -
Revue Du Rhumatisme Et Des Maladies... 1956
Topics: Prednisone; Rheumatic Diseases
PubMed: 13401177
DOI: No ID Found -
Nederlands Tijdschrift Voor Geneeskunde Jun 1979
Topics: Drug Administration Schedule; Facial Paralysis; Female; Follow-Up Studies; Humans; Middle Aged; Prednisone; Time Factors
PubMed: 460454
DOI: No ID Found -
Prensa Medica Argentina Nov 1957
Topics: Prednisone; Rheumatic Diseases; Rheumatology
PubMed: 13554096
DOI: No ID Found -
Therapie Der Gegenwart Feb 1959
Topics: Humans; Phenylbutazone; Prednisone; Tuberculosis; Tuberculosis, Pulmonary
PubMed: 13647474
DOI: No ID Found -
Therapie Der Gegenwart Jan 1959
Topics: Edema, Cardiac; Heart Failure; Prednisone
PubMed: 13647466
DOI: No ID Found -
Bollettino - Societa Medico Chirurgica... 1958
Topics: Liver Cirrhosis; Organic Chemicals; Prednisone
PubMed: 13572674
DOI: No ID Found