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Archives of Gynecology and Obstetrics Sep 2014
Topics: Female; Humans; Maternal Age; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk
PubMed: 24927780
DOI: 10.1007/s00404-014-3298-1 -
Journal of Developmental Origins of... Oct 2021Women with thyroid diseases at the beginning of pregnancy may have suboptimal thyroid hormone levels because of potential difficulties in compensating for the...
Women with thyroid diseases at the beginning of pregnancy may have suboptimal thyroid hormone levels because of potential difficulties in compensating for the physiological thyroid hormone changes occurring in pregnancy. Our objective was to study the association between preexisting thyroid diseases, pregnancy complications, and neonatal anthropometry. In total, 16,395 women from the ELFE French longitudinal birth cohort were included, and 273 declared pre-pregnancy thyroid diseases. Associations were investigated with multivariable regression models, with adjustment for relevant potential confounders. Body mass index (BMI) was additionally adjusted for in a second stage. As compared with other women, women with pre-pregnancy thyroid diseases were more frequently obese (19.6% vs. 9.8%) and had greater odds of gestational diabetes development (odds ratio [OR] = 1.58 [95% confidence interval [CI] 1.08, 2.30]) or had undergone treatment for infertility (OR = 1.57 [95% CI 1.07, 2.31]). After adjustment for BMI, the association with gestational diabetes was no longer significant (OR = 1.27 [95% CI 0.86, 1.88]). After excluding women with another medical history, those with pre-pregnancy thyroid diseases had increased odds of premature rupture of membranes (OR = 1.51 [95% CI 1.01, 2.25]). Children born from mothers with hypothyroidism before conception due to a disease or as a potential side effect of treatment had a smaller head circumference at birth than other children (β = -0.23 [95% CI -0.44, -0.01] cm). In conclusion, pre-pregnancy thyroid diseases were associated with risk of infertility treatment, gestational diabetes, and premature rupture of membranes. The association between history of hypothyroidism and moderate adverse effects on fetal head circumference growth needs replication.
Topics: Adult; Cohort Studies; Female; France; Humans; Pregnancy; Pregnancy Outcome; Thyroid Diseases
PubMed: 33300489
DOI: 10.1017/S2040174420001051 -
Journal of UOEH Jun 1990
Review
Topics: Abortion, Spontaneous; Cluster Analysis; Computer Systems; Congenital Abnormalities; Female; Humans; Medical Record Linkage; Pregnancy; Pregnancy Outcome; Surveys and Questionnaires
PubMed: 2202035
DOI: 10.7888/juoeh.12.143 -
Prenatal Diagnosis Sep 2021To assess the association between low fetal fraction (FF) in prenatal cell-free DNA (cfDNA) testing and adverse pregnancy outcomes.
OBJECTIVES
To assess the association between low fetal fraction (FF) in prenatal cell-free DNA (cfDNA) testing and adverse pregnancy outcomes.
METHODS
We conducted a retrospective cohort study of participants of the TRIDENT-2 study (Dutch nationwide government-supported study offering cfDNA screening for fetal aneuploidies) who received a failed test result due to low FF (<4%) between April 2017 until February 2018. Outcome measures included pregnancy-induced hypertension (PIH), pre-eclampsia (PE), small for gestational age neonates (SGA), spontaneous preterm birth (sPTB), gestational diabetes mellitus (GDM), chromosomal aberrations, and congenital structural anomalies.
RESULTS
Test failure due to low FF occurred in 295 women (1.12% of tests performed). Information regarding pregnancy outcomes was available for 96.3% of these women. The incidence of PIH, PE, SGA, sPTB, and GDM was 11.2%, 4.1%, 7.3%, 5.1%, and 14.8%, respectively. The prevalence of chromosomal aberrations and congenital structural anomalies was 1.4% and 4.1%, respectively. Incidences of PIH, PE ≥ 34 weeks of gestation, GDM, and prevalence of aneuploidy and congenital structural anomalies were higher in women with low FF compared to the general Dutch obstetric population.
CONCLUSION
Low FF is associated with adverse pregnancy outcomes. The value of FF in the prediction of these outcomes needs to be further established.
Topics: Adult; Cell-Free Nucleic Acids; Cohort Studies; Female; Humans; Pregnancy; Pregnancy Outcome; Prenatal Diagnosis; Retrospective Studies; Risk Factors
PubMed: 34426993
DOI: 10.1002/pd.6034 -
BMJ (Clinical Research Ed.) Aug 2010
Topics: Abortion, Spontaneous; Birth Intervals; Female; Humans; Pregnancy; Pregnancy Outcome
PubMed: 20688843
DOI: 10.1136/bmj.c4181 -
The Lancet. Psychiatry Oct 2023
Topics: Pregnancy; Female; Humans; Pregnancy Outcome; Mental Health; Mental Disorders; Pregnancy Complications
PubMed: 37591295
DOI: 10.1016/S2215-0366(23)00236-5 -
The Journal of Maternal-fetal &... Nov 2020Many studies have reported on the association of reduced fetal movements and stillbirth, but little is known about excessive fetal movements and adverse pregnancy...
Many studies have reported on the association of reduced fetal movements and stillbirth, but little is known about excessive fetal movements and adverse pregnancy outcome. First described in 1977, sudden excessive fetal movement was noted to reflect acute fetal distress and subsequent fetal demise. Subsequently, little was reported regarding this phenomenon until 2012. However, emerging data suggest that 10-30% of the women that subsequently suffer a stillbirth describe a single episode of excessive fetal movement prior to fetal demise. These episodes are poorly understood but may reflect fetal seizure activity secondary to fetal asphyxia, cord entanglement or an adverse intrauterine environment. At present, the challenge in managing women with excessive fetal movements is a timely assessment of the fetus to identify those women at risk of adverse fetal outcomes who may benefit from intervention.
Topics: Female; Fetal Death; Fetal Movement; Humans; Pregnancy; Pregnancy Outcome; Prenatal Care; Stillbirth
PubMed: 30744445
DOI: 10.1080/14767058.2019.1582027 -
Journal of the American College of... Mar 2021
Topics: Female; Humans; Obesity, Maternal; Pre-Eclampsia; Pregnancy; Pregnancy Outcome
PubMed: 33706875
DOI: 10.1016/j.jacc.2021.01.023 -
Current Opinion in Obstetrics &... Dec 1999Several environmental factors affect the fetus and thereby the outcome of pregnancy. Recent studies have confirmed a relation between stress and pregnancy outcome;...
Several environmental factors affect the fetus and thereby the outcome of pregnancy. Recent studies have confirmed a relation between stress and pregnancy outcome; furthermore they have indicated that biological measures of stress may predict risk of complications. Altered sex ratio may be an interesting way of measuring the effect of stress during pregnancy. Stress and work load during pregnancy seem to be related to time until conception and to becoming pregnant through assisted reproduction. Drinking large amounts of alcohol is hazardous, but drinking one drink per day appears to be safe. The effect of passive smoking continues to be a matter of debate.
Topics: Female; Humans; Life Style; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Reproductive Techniques; Sex Ratio; Smoking; Stress, Psychological; Substance-Related Disorders; Women, Working; Workload
PubMed: 10674831
DOI: 10.1097/00001703-199912000-00003 -
American Journal of Obstetrics and... May 2007The purpose of this study was to identify correlates of anxiety symptoms during pregnancy and determine the strength of the relationship between anxiety symptoms and... (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
The purpose of this study was to identify correlates of anxiety symptoms during pregnancy and determine the strength of the relationship between anxiety symptoms and adverse perinatal outcomes.
STUDY DESIGN
A meta-analytic review was conducted of studies that evaluated the relationship between self-reported anxiety symptoms during pregnancy and potential correlates or perinatal outcomes.
RESULTS
Fifty studies of 48 samples of women met inclusion criteria. Anxiety symptoms during pregnancy were associated with a number of psychosocial variables including depressive symptoms (r = 0.66), stress (r = 0.40), and self-esteem/self-worth (r = -0.47). There were no significant associations of anxiety symptoms with perinatal outcomes (all rs < 0.19).
CONCLUSION
Anxiety symptoms during pregnancy appear to be associated with similar psychosocial variables as anxiety at other times. There is no evidence of an association of anxiety symptoms with adverse perinatal outcomes among those studied thus far. However, significant gaps still exist in the literature in this area.
Topics: Anxiety; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Self-Assessment
PubMed: 17466693
DOI: 10.1016/j.ajog.2007.03.042