-
Andrologia Feb 2020To explore the efficacy of regular penis-root masturbation (PRM) versus Kegel exercise (KE) in the treatment of primary premature ejaculation (PPE). This study was a... (Randomized Controlled Trial)
Randomized Controlled Trial
To explore the efficacy of regular penis-root masturbation (PRM) versus Kegel exercise (KE) in the treatment of primary premature ejaculation (PPE). This study was a prospective quasi-randomised controlled trial. Thirty-seven heterosexual males with PPE were selected according to the time sequence of outpatient consultations and the preliminary results of a pre-experiment and were assigned to an PRM group and a KE group. Differences in intravaginal ejaculatory latency times (IELTs) and premature ejaculation diagnostic tool (PEDT) scores were compared between the two groups. The study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University. Among the 37 PPE patients, 18 performed PRM and 19 patients performed KE. The IELTs of patients who performed PRM and KE were significantly prolonged before treatment, and the difference after treatment was statistically significant (p < .05). Compared with the KE group, the IELT prolongation effect in the PRM group was more significant PRM (p < .05). The PEDT scores of patients after performing PRM and KE were significantly lower than those before performing these exercises (p < .05). Compared with the KE group, the PEDT scores of the PRM group exhibited a greater decrease (p < .05). Thus, both PRM and KE have therapeutic effects on PPE. Compared with KE, PRM is more effective in the treatment of PPE.
Topics: Adult; Ejaculation; Exercise Therapy; Humans; Male; Masturbation; Premature Ejaculation; Prospective Studies; Time Factors; Treatment Outcome; Young Adult
PubMed: 31746051
DOI: 10.1111/and.13473 -
Expert Opinion on Pharmacotherapy Jul 2018Various drugs are available for lifelong and acquired premature ejaculation (PE), but only dapoxetine and Fortacin have been officially registered. On the other hand,... (Review)
Review
INTRODUCTION
Various drugs are available for lifelong and acquired premature ejaculation (PE), but only dapoxetine and Fortacin have been officially registered. On the other hand, all sorts of pharmacologically not-investigated over-the-counter-products (OTCs) are used by men with complaints of PE with normal ejaculation time durations (subjective PE). There is a need to critically review the current state of registered and nonregistered drugs for PE.
AREAS COVERED
In this review, the authors use the guideline of the International Society for Sexual Medicine (ISSM) for the treatment of PE and provide evidence-based recommendations for the pharmacotherapy of lifelong and acquired PE. This should always be accompanied by psychoeducation, counseling, and information about common and rare side effects of the various available drugs.
EXPERT OPINION
As long as subjective PE is not officially recognized as the third PE subtype, registration authorities will continue to demand drugs for subjective PE to be studied in men with lifelong PE. This is unfortunate as the method and design of studies of drugs for subjective PE differ from those of lifelong PE but also because drugs for subjective PE need to be investigated in men with subjective PE and not in men with lifelong PE.
Topics: Analgesics, Opioid; Anesthetics, Local; Clomipramine; Counseling; Humans; Male; Nausea; Phosphodiesterase 5 Inhibitors; Premature Ejaculation; Selective Serotonin Reuptake Inhibitors
PubMed: 30028639
DOI: 10.1080/14656566.2018.1494725 -
Medicine Feb 2019As one of the common male sexual dysfunction diseases, the treatment effect of premature ejaculation is often difficult to guarantee. In China, there are many randomized... (Review)
Review
BACKGROUND
As one of the common male sexual dysfunction diseases, the treatment effect of premature ejaculation is often difficult to guarantee. In China, there are many randomized clinical trials that confirm that acupuncture has a good therapeutic effect on premature ejaculation. The aim of this study was to compare the efficacy and safety of acupuncture for premature ejaculation from intravaginal ejaculation latency (IELT), premature ejaculation diagnostic tool (PEDT), Arab premature ejaculation index (AIPE), and premature ejaculation index (IPE).
METHODS
We will use PubMed, EMBASE, Nursing and Related Health Literature Cumulative Index, Joint and Supplemental Drug Database, Cochrane Center Controlled Trials Registry (CENTRAL), China Biomedical Literature Database (CBM) and China Knowledge Infrastructure (CNKI), The Chinese Science and Technology Periodical Database (VIP), and Wanfang Database conduct systematic searches until October 31, 2018. At the same time, manually search for gray documents, including unpublished meeting articles. The primary outcome included intravaginal ejaculation latency (IELT). Secondary outcomes were premature ejaculation diagnostic tools (PEDT), Arab premature ejaculation index (AIPE), and premature ejaculation index (IPE). The quality and evidence that the risk of inclusion of the BiB tool will be assessed will be assessed on a scale.
RESULTS
This study will generate a comprehensive review of current evidence of acupuncture for premature ejaculation.
CONCLUSION
The study will provide updated evidence to evaluate the efficacy and safety of acupuncture for premature ejaculation.
ETHICS AND COMMUNICATION
Because this research is based on a meta-analysis of published research, ethical recognition and patient consent are unnecessary.
AGREEMENT REGISTRATION NUMBER
PROSPERO CRD42018111661.
Topics: Acupuncture Therapy; China; Humans; Male; Premature Ejaculation; Randomized Controlled Trials as Topic; Research Design
PubMed: 30702567
DOI: 10.1097/MD.0000000000014147 -
International Journal of Urology :... Jan 2017Premature ejaculation is the most common form of sexual dysfunction among men. The pathophysiology of premature ejaculation appears to be multifactorial, implicating the... (Review)
Review
Premature ejaculation is the most common form of sexual dysfunction among men. The pathophysiology of premature ejaculation appears to be multifactorial, implicating the need for multimodal therapeutic regimens to successfully treat premature ejaculation. Multiple treatment regimens have been shown to be effective in extending the time between penetration and ejaculation. These treatment modalities include everything from behavioral modifications and medications to diet alterations and major surgery. The goal of the present article was to review the commonly used treatment regimens used in the treatment of premature ejaculation, as well as to introduce and discuss the newest treatment routines under study for the treatment of premature ejaculation.
Topics: Acupuncture; Anesthetics, Local; Animals; Behavior Therapy; Circumcision, Male; Disease Models, Animal; Ejaculation; Humans; Male; Penis; Phosphodiesterase 5 Inhibitors; Plant Extracts; Premature Ejaculation; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Treatment Outcome; Varicocele; Yoga
PubMed: 27704632
DOI: 10.1111/iju.13202 -
Journal of Endocrinological... Nov 2022The specific underlying mechanisms supporting the association between erectile dysfunction (ED) and premature ejaculation (PE) are still not completely clarified. To... (Review)
Review
PURPOSE
The specific underlying mechanisms supporting the association between erectile dysfunction (ED) and premature ejaculation (PE) are still not completely clarified. To summarize and discuss all available data supporting the relationship between PE and ED.
METHODS
A comprehensive narrative review was performed. In addition, to better clarify the specific factors underlining ED and PE, a meta-analytic approach of the selected evidence was also performed. In particular, the meta-analytic method was selected in order to minimize possible sources of bias derived from a personal interpretation of the data.
RESULTS
Current data confirm the close association between ED and PE and the bidirectional nature of their relationship. In particular, PE was associated with a fourfold increased risk of ED independently of the definition used. In addition, the risk increased in older patients and in those with lower education, and it was associated with higher anxiety and depressive symptoms. Conversely, ED-related PE was characterized by lower associations with organic parameters such as diabetes mellitus, arterial hypertension, dyslipidemia and with smoking habit. Finally, when ED was defined according to the International Index of Erectile Function questionnaire, the presence of a stable relationship increased the risk.
CONCLUSIONS
ED and PE should be considered in a dimensional prospective way considering the possibility that both clinical entities can overlap and influence each. Correctly recognizing the underlying factors and sexual complaint can help the clinician in deciding the more appropriate diagnostic and therapeutic work-up.
Topics: Aged; Anxiety; Ejaculation; Erectile Dysfunction; Humans; Male; Premature Ejaculation; Sexual Behavior; Surveys and Questionnaires
PubMed: 35503598
DOI: 10.1007/s40618-022-01793-8 -
Sexual Medicine Reviews Apr 2022Fifteen years have passed since the International Society of Sexual Medicine first established the 3-pronged criteria for premature ejaculation (PE): a short ejaculation... (Review)
Review
INTRODUCTION
Fifteen years have passed since the International Society of Sexual Medicine first established the 3-pronged criteria for premature ejaculation (PE): a short ejaculation latency, lack of ejaculatory control, and bother/distress. Although the process of establishing valid criteria for any condition or disorder is an ongoing one, a dearth of targeted research on these criteria has hindered professional societies from updating and revising them.
OBJECTIVES
To review and critique existing criteria used in the diagnosis of PE, to identify specific problems with them, and to recommend studies that will address shortcomings.
METHODS
Each of the PE criteria was evaluated and compared against standard procedures for establishing validated measures. Following each analysis, targeted research to address the gaps has been recommended.
RESULTS
Each PE criterion has shortcomings and each can be improved by using standard validation procedures, as noted by the targeted research outcomes. Professional societies can play an important role by encouraging broad participation in research that generates new and relevant data supporting, validating, or challenging the existing criteria.
CONCLUSION
The concepts underlying the diagnostic criteria for PE have both broad consensus and functional utility. Nevertheless, much of the research investigating PE has uncritically adopted these criteria without concomitantly recognizing their limitations. These limitations prevent determining accurate prevalence rates, interpreting research findings with confidence, and establishing efficacious treatment outcomes. Rowland DL, Althof SE, McMahon CG. The Unfinished Business of Defining Premature Ejaculation: The Need for Targeted Research. Sex Med Rev 2022;10:323-340.
Topics: Ejaculation; Humans; Male; Premature Ejaculation; Sexual Behavior; Treatment Outcome
PubMed: 34996746
DOI: 10.1016/j.sxmr.2021.11.003 -
Balkan Medical Journal Oct 2023
Topics: Male; Humans; Premature Ejaculation
PubMed: 37519007
DOI: 10.4274/balkanmedj.galenos.2023.2023-6-47 -
Drug Discovery Today Jul 2016Premature ejaculation (PE) subjectively affects 20-30% of men globally. Until recently, understanding of PE was hampered by the absence of a widely accepted definition,... (Review)
Review
Premature ejaculation (PE) subjectively affects 20-30% of men globally. Until recently, understanding of PE was hampered by the absence of a widely accepted definition, paucity of evidence-based clinical studies, and the absence of an appropriate animal model. Here, we elaborate on the current definition of PE, its pathogenesis, currently available therapies, and future treatment prospects. Most treatments for PE are 'off-label' and include selective serotonin reuptake inhibitors (SSRIs), topical anesthetics, tramadol, and phosphodiesterase type 5 (PDE5) inhibitors. Such knowledge of the benefit and limitations of each treatment will help to direct future drug design and formulations.
Topics: Animals; Ejaculation; Humans; Premature Ejaculation
PubMed: 27179987
DOI: 10.1016/j.drudis.2016.05.004 -
International Journal of Impotence... Dec 2022Professional standards committees have generally applied the diagnostic criteria for premature ejaculation only to situations involving (presumed) heterosexual men... (Review)
Review
Professional standards committees have generally applied the diagnostic criteria for premature ejaculation only to situations involving (presumed) heterosexual men having penile-vaginal intercourse. This paper reviews the existing evidence supporting expansion of the criteria for use among non-straight men engaging in sexual activities that do not include vaginal intercourse. In brief, estimated ejaculation latencies appear similar across men identifying with different sexual orientations, and various partnered sexual activities (oral, vaginal, and manual) tend to be well correlated. In contrast, masturbation latency patterns are different between men with and without premature ejaculation, and ejaculatory control and bother/distress may be less critical to gay men than straight men during partnered sex. Finally, it should be noted that existing patient report outcomes (PROs) require modification for use with non-straight men.
Topics: Male; Female; Humans; Premature Ejaculation; Coitus; Ejaculation; Sexual Behavior; Masturbation
PubMed: 34504313
DOI: 10.1038/s41443-021-00467-y -
Australian Family Physician May 2013International studies suggest that premature ejaculation (PE) is the most common type of male sexual dysfunction, affecting 14-30% of males aged 18 years and over. The...
International studies suggest that premature ejaculation (PE) is the most common type of male sexual dysfunction, affecting 14-30% of males aged 18 years and over. The personal nature of PE, and the hesitancy of both patients and clinicians to raise the subject, means that only a small proportion of those affected seek or receive professional help.
Topics: Adolescent; Adult; Humans; Male; New South Wales; Premature Ejaculation; Prevalence; Retrospective Studies; Risk Factors; Young Adult
PubMed: 23781521
DOI: No ID Found