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FEMS Immunology and Medical Microbiology Mar 1993Black-pigmented Gram-negative anaerobes are part of the normal vaginal flora and contribute to a range of superficial and deep genital infections. Prevotella... (Review)
Review
Black-pigmented Gram-negative anaerobes are part of the normal vaginal flora and contribute to a range of superficial and deep genital infections. Prevotella melaninogenica is found in moderate numbers (10(4-6) cfu/g) in healthy women; the numbers and detection rates increase in anaerobic vaginosis (where it may be a significant contributor to changed microbial metabolic activity that gives the signs and symptoms of this condition) and in other vaginal infective conditions. Pr. melaninogenica is also part of the mixed flora in deep pelvic infections: endometritis, post-partum and post-abortal uterine infections; salpingitis and tubo-ovarian abscesses; PID and pelvic abscesses. Porphyromonas asaccharolytica is probably not a vaginal commensal, but may be isolated from patients with vaginal or pelvic disease. It is more specifically associated with superficial abscesses (e.g. Bartholin's abscess) and ulcers of the genitalia and perineum. P. asaccharolytica was the commonest species isolated from men with genital ulcers of various primary causes and ranging in severity from superficial balanitis/balanoposthitis to synergic gangrene.
Topics: Abscess; Bacteroidaceae; Bacteroidaceae Infections; Balanitis; Endometritis; Female; Female Urogenital Diseases; Genitalia; Humans; Male; Male Urogenital Diseases; Puerperal Disorders; Ulcer; Vaginitis; Virulence
PubMed: 8518760
DOI: 10.1111/j.1574-695X.1993.tb00331.x -
Lancet (London, England) May 1983
Topics: Adolescent; Anti-Bacterial Agents; Bacteroides; Drug Resistance, Microbial; Female; Humans; Male; Metronidazole; Prevotella melaninogenica
PubMed: 6134014
DOI: No ID Found -
JAMA Aug 1982
Topics: Aged; Bacteroides; Humans; Male; Penicillin G; Penicillin Resistance; Pneumonia; Prevotella melaninogenica
PubMed: 6124641
DOI: No ID Found -
Microbiological Reviews Sep 1982
Review
Topics: Animals; Bacillus subtilis; Bacteria; Escherichia coli; Genes, Bacterial; Intestines; Ketoglutaric Acids; Lactobacillus; Methylation; Mycobacterium; Naphthols; Oxygen; Phenylbutyrates; Prevotella melaninogenica; Shikimic Acid; Staphylococcus aureus; Vitamin K; Vitamin K 2
PubMed: 6127606
DOI: 10.1128/mr.46.3.241-280.1982 -
Clinical Infectious Diseases : An... Sep 1997The frequency of beta-lactamase production by oral pigmented Prevotella species isolated from 23 healthy young children and the minimal inhibitory concentrations (MICs)...
The frequency of beta-lactamase production by oral pigmented Prevotella species isolated from 23 healthy young children and the minimal inhibitory concentrations (MICs) for 186 available beta-lactamase-positive isolates were examined by using the chromogenic cephalosporin disk test (AB BIODISK, Solna, Sweden) and the Etest (AB BIODISK) and/or the agar dilution method of the National Committee for Clinical Laboratory Standards (Villanova, PA, USA), respectively. beta-Lactamase-positive Prevotella melaninogenica strains were isolated from all children, and more than two-thirds of the Prevotella denticola and Prevotella loescheii strains isolated from the children were beta-lactamase-positive. The beta-lactamase-producing Prevotella intermedia group consisted of Prevotella nigrescens and the P. intermedia/ P. nigrescens-like organism (PINLO); P. intermedia was not found. Only two P. nigrescens isolates but most of the PINLO isolates produced beta-lactamase. The MICs for beta-lactamase-producing strains varied between 0.38 and 64 micrograms/mL. beta-Lactamase production by oral pigmented Prevotella species colonizing young children is already frequent. The phenomenon should be taken into account in the treatment of pediatric anaerobic infections of oral origin.
Topics: Child, Preschool; Humans; Prevotella; beta-Lactamases
PubMed: 9310704
DOI: 10.1086/516208 -
International Journal of Clinical &... 1993In this study we provide evidence that structural and soluble components of periodontopathogenic bacteria, such as Prevotella melaninogenica and Fusobacterium nucleatum,...
Human monocytes and gingival fibroblasts release tumor necrosis factor-alpha, interleukin-1 alpha and interleukin-6 in response to particulate and soluble fractions of Prevotella melaninogenica and Fusobacterium nucleatum.
In this study we provide evidence that structural and soluble components of periodontopathogenic bacteria, such as Prevotella melaninogenica and Fusobacterium nucleatum, induce the release of cytokines in vitro known to cause in vivo necrotic inflammatory phenomena and bone resorption (tumor necrosis factor-alpha, interleukin-1 alpha and interleukin-6). Human monocytes and gingival fibroblasts were cultivated in vitro in the presence of both particulate and soluble bacterial fractions. A dose-dependent production of tumor necrosis factor-alpha by monocytes and gingival fibroblasts was observed in the presence of fractions of P. melaninogenica and F. nucleatum. Interleukin-1 alpha was produced in approximately the same quantities in the presence of soluble fractions of either P. melaninogenica or F. nucleatum, but in greater quantities in response to particulate fractions of P. melaninogenica. Monocytes released larger amounts of interleukin-1 alpha (about 3000 pg/ml) than gingival fibroblasts (about 1500 pg/ml). Interleukin-6 was released in greater quantities by monocytes in the presence of the pellet fraction of P. melaninogenica (about 5.5 ng/ml), but gingival fibroblasts released larger amounts of interleukin-6, especially in the presence of particulate and soluble components of F. nucleatum (about 12 ng/ml). The ability to induce the release of these cytokines notably increases the pathogenic potential of the bacteria involved in the damage of periodontal tissue.
Topics: Chemical Fractionation; Cytokines; Fibroblasts; Fusobacterium; Gingiva; Gram-Negative Bacteria; Humans; Inflammation; Interleukin-1; Interleukin-6; Monocytes; Solubility; Tumor Necrosis Factor-alpha
PubMed: 8400338
DOI: 10.1007/BF02592303 -
Lancet (London, England) Nov 1978
Topics: Ampicillin; Bacteroides Infections; Bacteroides fragilis; Brain Abscess; Chloramphenicol; Fusidic Acid; Gentamicins; Humans; Metronidazole; Penicillins; Prevotella melaninogenica; Staphylococcal Infections; Streptococcal Infections
PubMed: 82092
DOI: No ID Found -
International Journal of Systematic... Apr 1990It was recently proposed that the genus Bacteroides should be restricted to Bacteroides fragilis (the type species) and closely related organisms (viz., B. caccae, B....
It was recently proposed that the genus Bacteroides should be restricted to Bacteroides fragilis (the type species) and closely related organisms (viz., B. caccae, B. distasonis, B. eggerthii, B. merdae, B. ovatus, B. stercoris, B. thetaiotaomicron, B. uniformis, and B. vulgatus). By contrast, the moderately saccharolytic, predominantly oral Bacteroides species, which include B. melaninogenicus, B. oralis, and related species, form a phenotypically and phylogenetically coherent group of species which differ so significantly from the emended description of the genus Bacteroides that they should not be classified in the same genus. Therefore, we formally propose that these species be reclassified in a new genus, Prevotella. The type species is Prevotella melaninogenica.
Topics: Bacteria; Bacteroides; Chemical Phenomena; Chemistry; Ecology; Terminology as Topic
PubMed: 2223612
DOI: 10.1099/00207713-40-2-205 -
Archives of Biochemistry and Biophysics Mar 2020Oral microbes are a contributing factor to hyperglycemia by inducing an increase in insulin resistance resulting in uncontrolled blood glucose levels. However, the...
Oral microbes are a contributing factor to hyperglycemia by inducing an increase in insulin resistance resulting in uncontrolled blood glucose levels. However, the relationship between the distribution of oral flora and hyperglycemia is still controversial. Combining the power of MALDI-Biotyper with anaerobic bacterial culture, this study explores the correlation between anaerobic bacteria in the oral cavity and blood glucose levels. The results demonstrated that altered blood glucose levels contributed to a varied bacterial distribution in the oral cavity. Specifically, Veillonella spp. and Prevotella spp. were identified in a higher proportion in people with elevated blood glucose levels. Six bacterial species identified in this study (Prevotella melaninogenica, Campylobacter rectus, Streptococcus gordonii, Streptococcus mitis, Streptococcus salivarius, and Veillonella parvula) not only demonstrated a positive association with higher blood glucose levels, but also likely contribute to the development of the condition. The data demonstrated MALDI-TOF MS to be a simpler, faster, and more economical clinical identification tool that provides clarity and depth to the research on blood glucose and oral microbiota.
Topics: Adult; Aged; Bacteria, Anaerobic; Blood Glucose; Campylobacter rectus; Female; Gingiva; Glycated Hemoglobin; Humans; Hyperglycemia; Male; Microbiota; Middle Aged; Prevotella; Prevotella melaninogenica; Saliva; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Streptococcus gordonii; Streptococcus mitis; Streptococcus salivarius; Veillonella
PubMed: 31981541
DOI: 10.1016/j.abb.2020.108278 -
Lancet (London, England) Jan 1979
Topics: Abscess; Bacteroides Infections; Escherichia coli Infections; Female; Humans; Mastitis; Neutrophils; Phagocyte Bactericidal Dysfunction; Pregnancy; Prevotella melaninogenica; Recurrence; Streptococcal Infections
PubMed: 84192
DOI: 10.1016/s0140-6736(79)90564-6