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Nursing May 1984
Topics: Humans; Procainamide
PubMed: 6562401
DOI: 10.1097/00152193-198405000-00038 -
British Journal of Clinical Pharmacology Oct 19771 Data from a comprehensive drug surveillance programme are analysed to provide details of procainamide use and toxicity in medical wards of teaching hospitals in five...
1 Data from a comprehensive drug surveillance programme are analysed to provide details of procainamide use and toxicity in medical wards of teaching hospitals in five countries. 2 Out of a total of 488 recipients 9.2% had one or more adverse effect attributed to the drug; common effects being arrhythmias, gastro-intestinal upsets and drug fever. Although occasionally of major severity, no patient died as a consequence of procainamide toxicity. 3 Toxicity was directly related to total daily dose and duration of hospitalization but was not related to age, weight of the patient or presenting urea or albumin concentrations.
Topics: Aged; Arrhythmias, Cardiac; Female; Heart Ventricles; Humans; Male; Procainamide; Time Factors
PubMed: 911600
DOI: 10.1111/j.1365-2125.1977.tb00777.x -
The Journal of Laboratory and Clinical... Mar 1992Procainamide has been used extensively for the treatment of ventricular arrhythmias. It is widely held that the sympathetic nervous system plays an important role in the...
Procainamide has been used extensively for the treatment of ventricular arrhythmias. It is widely held that the sympathetic nervous system plays an important role in the pathogenesis of ventricular arrhythmias. We investigated the possibility that procainamide has effects on the sympathetic nervous system by determining the responses to procainamide of postganglionic renal and preganglionic lumbar nerve activity in rabbits with sinoaortic and vagal denervation. Bolus administration of procainamide (3, 7, and 15 mg/kg) resulted in dose-dependent decreases in renal sympathetic nerve activity (26%, 38%, and 57%, respectively). These boluses resulted in plasma levels of procainamide of 13.3, 23.6, and 41.7 micrograms/ml, respectively. The same doses of procainamide resulted in decreases in lumbar nerve activity of 36%, 36%, and 41%, respectively. In a separate group of rabbits pretreated with hexamethonium (n = 8), 15 mg/kg procainamide reduced lumbar nerve traffic by 38%. Infusion of procainamide at 1 mg/kg/min over 20 minutes (n = 9) resulted in a decrease in renal sympathetic nerve activity of 20% with a plasma level of 11 micrograms/ml. Sham-treated rabbits (n = 8) exhibited an 18% increase in traffic over a comparable period of time. We conclude that procainamide inhibits lumbar and renal sympathetic nerve activity through effects on the brain or spinal cord. The influence of procainamide on sympathetic nerve activity may contribute importantly to its efficacy in the therapy of ventricular arrhythmias.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intravenous; Procainamide; Rabbits; Sympathetic Nervous System; Synaptic Transmission
PubMed: 1311739
DOI: No ID Found -
DICP : the Annals of Pharmacotherapy Dec 1991We report the case of a 65-year-old black man who presented to our facility with pseudo-obstruction of the bowel within two weeks of the initiation of oral...
We report the case of a 65-year-old black man who presented to our facility with pseudo-obstruction of the bowel within two weeks of the initiation of oral sustained-release procainamide hydrochloride therapy. The syndrome continued despite conversion to intravenous procainamide and only resolved after discontinuation of the medication. We believe that the anticholinergic properties of procainamide, coupled with the patient's diabetes, contributed to severe hypomotility of the gastrointestinal tract and, subsequently, a pseudo-obstructive state. The syndrome of drug-induced pseudo-obstruction is also reviewed.
Topics: Aged; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Humans; Intestinal Pseudo-Obstruction; Male; Procainamide
PubMed: 1815428
DOI: 10.1177/106002809102501210 -
British Journal of Clinical Pharmacology Dec 1975Using in vitro techniques it was confirmed that whilst the release of procainamide from the conventional formulation (Pronestyl) was rapid, that from the... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
Using in vitro techniques it was confirmed that whilst the release of procainamide from the conventional formulation (Pronestyl) was rapid, that from the sustained-release preparation (Cardiorytmin Retard) occurred over a prolonged period. 2 The peak plasma procainamide concentrations after single doses of Cardiorytmin Retard were relatively lower and occurred later than those after single doses of Pronestyl. Furthermore, after reaching a peak, the fall in plasma procainamide concentration was less rapid after the sustained-release preparation. Early urinary recovery of procainamide in patients and in healthy volunteers was greater after Pronestyl than after Cardiorytmin Retard, though overall recovery in urine was similar. These findings indicate that the absorption of the sustained-release preparation is slower, though the overall bioavailabilities of the two preparations are almost the same. 3 These results confirm the feasibility of using a sustained-release procainamide preparation, such as Cardiorytmin Retard, since it would be possible to administer the same amount of drug in fewer daily doses without plasma concentrations becoming ineffective towards the end of each dosing interval.
Topics: Adult; Aged; Delayed-Action Preparations; Humans; Intestinal Absorption; Middle Aged; Procainamide; Solubility
PubMed: 1234015
DOI: 10.1111/j.1365-2125.1975.tb00569.x -
Cardiovascular Drugs and Therapy Apr 1989The effects of oral sotalol were compared with 1000 and 1500 mg of procainamide in 23 patients with sustained ventricular tachycardia. The predictive value of an... (Comparative Study)
Comparative Study
UNLABELLED
The effects of oral sotalol were compared with 1000 and 1500 mg of procainamide in 23 patients with sustained ventricular tachycardia. The predictive value of an induction study after procainamide was assessed. The mean age of the study group was 62 +/- 12 years, and the mean ejection fraction was 32 +/- 16%. The cycle length (CL) of the induced tachycardia, the coupling interval (CI) of the first extrastimulus (in ms), and the number of noninducible (NI) patients are given in the table below. (table; see text) One patient developed torsades during the loading period of sotalol and is included in the number requiring cardioversion (DC). Important proarrhythmic effects (spontaneous occurrence of tachycardia) were seen twice after procainamide. Induction suppression by procainamide predicted success with sotalol (p = 0.0013).
CONCLUSION
Ventricular tachycardia seems to be less often inducible after oral sotalol than after procainamide. The success of procainamide during programmed electrical stimulation predicts the same for sotalol. If ventricular tachycardia remains inducible after oral sotalol, it is faster than after procainamide but slower than the baseline tachycardia. Both drugs slightly prolong refractoriness.
Topics: Aged; Electric Stimulation; Electrophysiology; Heart Ventricles; Humans; Middle Aged; Procainamide; Sotalol; Tachycardia
PubMed: 2487531
DOI: 10.1007/BF01883859 -
Journal of the American Geriatrics... May 1977Procainamide-induced systemic lupus erythematosus (SLE) is a well recognized clinical syndrome believed to be characterized by normocomplementemia. However, in 7 cases...
Procainamide-induced systemic lupus erythematosus (SLE) is a well recognized clinical syndrome believed to be characterized by normocomplementemia. However, in 7 cases of drug-induced SLE recorded in the literature, hypocomplementemia was found. The present report concerns a well documented case of procainamide-induce SLE with hypocomplementemia. The patient improved and complement values returned to normal after procainamide therapy was discontinued and replaced by digitalis and steroid therapy.
Topics: Aged; Complement System Proteins; Digoxin; Female; Humans; Lupus Erythematosus, Systemic; Prednisone; Procainamide
PubMed: 853206
DOI: 10.1111/j.1532-5415.1977.tb00304.x -
Archiv Der Pharmazie Dec 1982
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Guinea Pigs; In Vitro Techniques; Mice; Procainamide; Rabbits
PubMed: 7159188
DOI: 10.1002/ardp.19823151205 -
The Journal of the Medical Society of... Mar 1970
Topics: Agranulocytosis; Arrhythmias, Cardiac; Desensitization, Immunologic; Humans; Leukopenia; Male; Methylprednisolone; Middle Aged; Procainamide
PubMed: 5264623
DOI: No ID Found -
Lancet (London, England) Jan 1968
Topics: Hiccup; Humans; Injections, Intramuscular; Procainamide
PubMed: 4169629
DOI: 10.1016/s0140-6736(68)92755-4