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Clinical and Molecular Hepatology Dec 2018
Topics: Cardiomyopathies; Humans; Liver Cirrhosis; Prognosis
PubMed: 30531663
DOI: 10.3350/cmh.2018.0098 -
ORL; Journal For Oto-rhino-laryngology... 2021This study aims to analyze possible preoperative factors taken from the medical history that may assist the otolaryngologist in counseling an adult patient before...
INTRODUCTION
This study aims to analyze possible preoperative factors taken from the medical history that may assist the otolaryngologist in counseling an adult patient before cochlear implantation (CI).
OBJECTIVE
Analysis of preoperative factors taken during the initial patient presentation for a possible prognostic role in the auditory rehabilitation outcome.
METHODS
A cohort of 232 (272 CI implantations) postlingually deafened adults was evaluated in this study. Hearing results at 1, 2, and up to 3 years postoperatively were compared with various preoperative factors: living status, cause of deafness, gender, side of implantation, residual hearing, and duration of deafness. Postoperative hearing performance was measured based on the German Freiburg monosyllabic word test and the Oldenburg sentence test.
RESULTS
Duration of deafness showed a negative correlation to word recognition and a positive correlation to increased speech reception threshold in sentence testing. A significant decline in hearing outcome was shown starting around the second decade of deafness. Residual hearing as defined in our cohort and side of implantation showed limited benefit in speech understanding. Living status, gender, and cause of deafness did not show any prognostic value.
CONCLUSION
In this retrospective review it could be shown that simple case history information can only provide limited prognostic insight before CI. The duration of deafness is the most reliable anamnestic factor present on initial patient evaluation.
Topics: Adult; Cochlear Implantation; Cochlear Implants; Deafness; Humans; Prognosis; Retrospective Studies; Speech Perception; Treatment Outcome
PubMed: 32950987
DOI: 10.1159/000509562 -
International Journal of Surgery... Nov 2023The tumor area may be a potential prognostic indicator. The present study aimed to determine and validate the prognostic value of tumor area in curable colon cancer.
Identification and initial validation of maximal tumor area as a novel prognostic factor for overall and disease-free survival in patients with resectable colon cancer: a retrospective study.
BACKGROUND
The tumor area may be a potential prognostic indicator. The present study aimed to determine and validate the prognostic value of tumor area in curable colon cancer.
METHODS
This retrospective study included a training and validation cohorts of patients who underwent radical surgery for colon cancer. Independent prognostic factors for overall survival (OS) and disease-free survival (DFS) were identified using Cox proportional hazards regression models. The prognostic discrimination was evaluated using the integrated area under the receiver operating characteristic curves (iAUCs) for prognostic factors and models. The prognostic discrimination between tumor area and other individual factors was compared, along with the prognostic discrimination between the tumor-node-metastasis (TNM) staging system and other prognostic models. Two-sample Wilcoxon tests were carried out to identify significant differences between the two iAUCs. A two-sided P <0.05 was considered statistically significant.
RESULTS
A total of 3051 colon cancer patients were included in the training cohort and 872 patients in the validation cohort. Tumor area, age, differentiation, T stage, and N stage were independent prognostic factors for both OS and DFS in the training cohort. Tumor area had a better OS and DFS prognostic discrimination characteristics than T stage, maximal tumor diameter, differentiation, tumor location, and number of retrieved lymph nodes. The novel prognostic model of T stage + N stage + tumor area (iAUC for OS, 0.714, P <0.001; iAUC for DFS, 0.694, P <0.001) showed a better prognostic discrimination than the TNM staging system (T stage + N stage; iAUC for OS, 0.664; iAUC for DFS, 0.658). Similar results were observed in an independent validation cohort.
CONCLUSIONS
Tumor area was identified as an independent prognostic factor for both OS and DFS in curable colon cancer patients, and in cases with an adequate number of retrieved lymph nodes. The novel prognostic model of combining T stage, N stage, and tumor area may be an alternative to the current TNM staging system.
Topics: Humans; Prognosis; Disease-Free Survival; Retrospective Studies; Neoplasm Staging; Colonic Neoplasms; Neoplasms, Second Primary
PubMed: 37526113
DOI: 10.1097/JS9.0000000000000623 -
Arquivos Brasileiros de Cardiologia Nov 2022
Topics: Female; Humans; Brazil; ST Elevation Myocardial Infarction; Prognosis
PubMed: 36453761
DOI: 10.36660/abc.20220688 -
Annals of Oncology : Official Journal... Oct 2019
Topics: Colorectal Neoplasms; Humans; Prognosis; Tumor Microenvironment
PubMed: 31504141
DOI: 10.1093/annonc/mdz294 -
Anticancer Research Feb 2021To identify prognostic factors for patients with stage IV gastric cancer (GC) and a single stage IV factor before chemotherapy who underwent conversion surgery (R0...
BACKGROUND/AIM
To identify prognostic factors for patients with stage IV gastric cancer (GC) and a single stage IV factor before chemotherapy who underwent conversion surgery (R0 resection).
PATIENTS AND METHODS
This study retrospectively analysed 32 GC patients with a single stage IV factor before chemotherapy and who underwent conversion surgery (R0 resection) between January 2001 and September 2015. The univariate and multivariate analyses were performed to identify independent prognostic factors.
RESULTS
The five-year survival rate was 39.6%, and the median survival time was 47.0 months. In the univariate analysis, diffuse-type according to Lauren classification was significantly associated with worse overall survival (p<0.001). In the multivariate analysis, diffuse-type was selected as an independent prognostic factor (hazard ratio=15.970, 95% confidence interval=3.804-67.043, p<0.001).
CONCLUSION
Diffuse-type may be a useful prognostic factor in GC patients with a single stage IV factor who undergo conversion surgery (R0 resection).
Topics: Adult; Aged; Aged, 80 and over; Conversion to Open Surgery; Female; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Analysis; Treatment Outcome
PubMed: 33517308
DOI: 10.21873/anticanres.14855 -
Breast (Edinburgh, Scotland) Apr 2022The prognostic factors and optimal choice of treatment for primary neuroendocrine neoplasms of the breast (BNEN) remain to be defined. (Review)
Review
BACKGROUND
The prognostic factors and optimal choice of treatment for primary neuroendocrine neoplasms of the breast (BNEN) remain to be defined.
METHODS
Patients diagnosed with BNEN in China were retrospectively reviewed from the literature following the systematic search of China National Knowledge Infrastructure (CNKI), Chinese biomedical literature service system (sinomed), wanfang medical network, and Pubmed database. The clinical characteristics and different treatment modalities of patients with BNEN were evaluated.
RESULTS
A total of 209 cases with BNEN were enrolled. There were 204 female and 5 male patients. The median age was 51 years old (range, 17-82). Out of 209 patients with BNEN, 208 (99.5%) patients were treated with surgery (SG), 44 patients (21.1%) had received radiotherapy (RT), 173 patients (82.8%) experienced chemotherapy (CT). A total of 158 patients with hormone receptor (HR) positive (87.8%, 158/180) were treated with endocrine treatment (ET). The median follow-up time was 52.4 months (range, 6-144). The 3-year overall survival (OS) rate and 3-year disease-free survival (DFS) rate for the whole group were 93.7% and 85.3%, respectively. In univariate analyses, Ki67 expression ≥20%, HR negative, neuroendocrine carcinomas (NECs) were associated with decreased OS and DFS (P < 0.05). Patients treated with anthracycline/taxane-containing CT regimens, or taxane-containing CT regimens had superior OS and DFS than patients without those (P < 0.05). Among 69 patients with stage I who received CT had no significant differences in OS or DFS compared to those without CT. Multivariate Cox regression analysis showed that gender, HR expression, pathologic subtype, and CT were independent prognostic factors for DFS but not OS (P > 0.05).
CONCLUSIONS
The best selection of patients to get the most benefit from different treatment modalities warrant further exploration. The clinicopathological parameters including gender, HR expression, ki67 expression, pathologic type, stage, tumor size, and lymph node status may serve as both indicators of diagnosis and prognosis, and guide treatment decisions for BNEN.
Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Retrospective Studies
PubMed: 35134665
DOI: 10.1016/j.breast.2022.01.013 -
JAMA Surgery Apr 2017
Topics: Prognosis; Surgeons
PubMed: 28052142
DOI: 10.1001/jamasurg.2016.5041 -
Journal of Clinical Oncology : Official... Dec 2023
Topics: Humans; Child; Prognosis; Chromosome Aberrations; In Situ Hybridization, Fluorescence
PubMed: 37820292
DOI: 10.1200/JCO.23.01760 -
Nederlands Tijdschrift Voor Geneeskunde Jun 2022Although it is generally known that a (statistical) association between a factor, i.e., determinant or independent variable, and outcome, i.e., dependent variable, does...
Although it is generally known that a (statistical) association between a factor, i.e., determinant or independent variable, and outcome, i.e., dependent variable, does not directly provide evidence of a causal relation, in practice the distinction between associative and causal relationships often becomes fuzzy when interpreting prognostic factor research. We provide suggestions for interpreting the findings of prognostic factor research. It is important to assess the purpose and design of the study, including the statistical analysis. The actual evidence that prognostic factor research can provide is easily overestimated. In particular when associations between factors and outcome are estimated in a multivariable analysis, causal or predictive qualities can easily but wrongfully be attributed to a prognostic factor. It is generally advisable to refrain from judgments on the causal of predictive qualities of a prognostic factor purely based on a prognostic factor study. Findings from prognostic factor research are usually a good starting point for follow-up research, while the direct applicability of such findings in daily medical practice is often limited.
Topics: Humans; Prognosis; Research Design
PubMed: 35899712
DOI: No ID Found