-
European Archives of... May 2021
Topics: Disease-Free Survival; Humans; Laryngeal Neoplasms; Neoplasm Staging; Prognosis; Tumor Burden
PubMed: 33420840
DOI: 10.1007/s00405-020-06523-5 -
Biomarkers in Medicine Apr 2023To assess the potential factors with predictive value for survival in small-cell lung cancer (SCLC) patients and to develop a nomogram prediction model. We...
To assess the potential factors with predictive value for survival in small-cell lung cancer (SCLC) patients and to develop a nomogram prediction model. We retrospectively screened and analyzed patients with pathologically confirmed SCLC from April 2015 to December 2021. A total of 167 patients with SCLC were included. According to the Memorial Sloan-Kettering prognostic score (MPS), patients were divided into three groups: group 0 (n = 65), group 1 (n = 69) and group 2 (n = 33). The multivariate analysis showed that MPS was an independent prognostic factor for progression-free and overall survival in SCLC patients (p < 0.05). The nomogram showed that MPS was the most influential factor for overall survival. MPS is an independent prognostic factor for overall and progression-free survival in SCLC patients and performed better than other indicators used in this study.
Topics: Humans; Prognosis; Lung Neoplasms; Retrospective Studies; Small Cell Lung Carcinoma; Nomograms
PubMed: 37381901
DOI: 10.2217/bmm-2023-0105 -
Clinical and Experimental Medicine Oct 2023The basic activities of daily life may affect the prognosis of multiple myeloma (MM) patients and the Barthel index (BI) is currently the most widely used tool to...
The basic activities of daily life may affect the prognosis of multiple myeloma (MM) patients and the Barthel index (BI) is currently the most widely used tool to evaluate basic activities of daily life, but few studies have evaluated its prognostic value in MM. We retrospectively enrolled patients with newly diagnosed MM and analyzed the association between the BI and the survival of newly diagnosed MM patients. We totally analyzed 538 patients and found that median overall survival (OS) and progression-free survival (PFS) were significantly shorter in the low BI (≤ 85) group compared with the high BI (> 85) group. Univariate Cox proportional hazards regression analysis showed that the low BI was associated with shorter OS and PFS. It was also confirmed that the low BI was poor prognostic factor for OS and PFS in multivariable analyses. In the propensity score matching analysis, patients with low BI also had shorter OS and PFS. Our study suggested that the low BI was a poor prognostic factor for patients with newly diagnosed MM.
Topics: Humans; Multiple Myeloma; Prognosis; Retrospective Studies
PubMed: 36703087
DOI: 10.1007/s10238-023-01002-7 -
BMC Cancer Sep 2014The aim of our study was to evaluate the histological characteristics and prognosis of gastric cancer.
BACKGROUND
The aim of our study was to evaluate the histological characteristics and prognosis of gastric cancer.
METHODS
Clinicopathlogical variables of 932 patients with gastric carcinoma admitted to the Department of Surgical Oncology at the First Hospital of China Medical University were analyzed retrospectively. Different histological characteristics of gastric cancer were summarized and assigned score according to the malignancy defined by WHO classification, the scores were stratified into 4 stage, the prognosis of different stages were analyzed by Kaplan-Meier analysis and cox regression.
RESULTS
Among the 932 patients, 246 (26.39%) had mixed histology type of gastric cancer. Compared to the pure histological type, mixed histological type of gastric cancer was significant associated with tumor size, lymph node metastasis and depth of invasion (all P < 0.05). The 5-year survival rates of advanced and early gastric cancer patients with mixed type were 40.8% and 83.5% respectively, which were lower than those with pure type (50.0% and 95.8%, P < 0.01). Statistically significant difference with stratification of early and advanced stage could be observed between patients with the histological grading score. The data showed that the histological score could be the independent factor of prognosis.
CONCLUSIONS
The histological score is an independent factor of gastric cancer, it exerts an excellent ability to classify survival of patients with gastric carcinoma. It also provides a new strategy and parameter for evaluating the biological behavior and prognosis of gastric cancer.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Prognosis; Stomach Neoplasms
PubMed: 25212951
DOI: 10.1186/1471-2407-14-663 -
Oral Oncology Jan 2020Oral cavity cancers are treated by surgery with or without adjuvant therapy. Being the most important prognostic factor, neck node management is an important aspect of... (Review)
Review
Oral cavity cancers are treated by surgery with or without adjuvant therapy. Being the most important prognostic factor, neck node management is an important aspect of treating oral cancers. There are numerous areas of debate in the management of the node-negative and node-positive neck. In an attempt to answer these questions, a large volume of literature has been generated over the last few decades. This review article describes the current evidence and approach considerations for the management of cervical nodes in patients with oral cavity cancers.
Topics: Humans; Lymph Node Excision; Lymphatic Metastasis; Mouth Neoplasms; Neck Dissection; Prognosis; Prophylactic Surgical Procedures; Treatment Outcome
PubMed: 31790914
DOI: 10.1016/j.oraloncology.2019.104476 -
The American Surgeon Nov 2023Negative lymph node (NLN)' s prognostic impact on stage III gastric cancer (GC) patients after curative gastrectomy has not been rigorously studied. We aimed to explore...
Negative Lymph Node Is an Independent Prognostic Factor for Stage III Gastric Cancer Patients After Curative Gastrectomy: A Surveillance, Epidemiology, and End Results-Based Study.
BACKGROUND
Negative lymph node (NLN)' s prognostic impact on stage III gastric cancer (GC) patients after curative gastrectomy has not been rigorously studied. We aimed to explore the relationship between NLNs count and outcomes of stage III GC patients.
METHODS
We retrospectively investigated stage III gastric cancer cases between 2008 and 2018 from Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by chi2 test. Kaplan-Meier methods and COX proportional hazard models were used to ascertain independent prognostic factors. Survival differences among the subgroups were analyzed to assess the effects of NLN count on overall survival (OS) in stage III GC patients.
RESULTS
2373 patients with curative gastrectomy for stage III GC were identified. Univariate analysis demonstrated that NLNs count >14 was associated better 5-year OS (43.7% VS 23.1%, < .001) comparing with the NLNs count ≤ 14. Subgroup analysis showed that the NLNs count could predict survival in both node-negative and node-positive patients. Multivariate analysis revealed NLNs count is an independent prognostic factor.
CONCLUSIONS
The NLNs count is an independent prognostic factor for survival in stage III gastric cancer patients after curative gastrectomy and should be recommended for clinical applications.
Topics: Humans; Prognosis; Neoplasm Staging; Stomach Neoplasms; Retrospective Studies; Lymphatic Metastasis; Gastrectomy; Lymph Nodes
PubMed: 35861326
DOI: 10.1177/00031348221114034 -
International Journal of Pediatric... May 2021Tympanoplasty performed in childhood has been controversial over the years because there is no clarity in determining what prognostic factors lead to surgical success....
Tympanoplasty performed in childhood has been controversial over the years because there is no clarity in determining what prognostic factors lead to surgical success. The objective of this study was to evaluate the effect of the Middle Ear Risk Index (MERI) score on the success of pediatric tympanoplasty. A retrospective case-control study was performed at a tertiary pediatric referral center. A database was created with surgical and clinical records of pediatric patients (<18 years of age) with tympanic membrane perforation, assessed and surgically managed by the same surgical team from January 2012 through March 2018. Mild MERI before tympanoplasty was found to be a protective factor against surgical failure, with an odds ratio of 0.24 (p: 0.002). The odds ratio for severe MERI in unsuccessful tympanoplasty was 5.87, with a p: 0.003, standing out as a risk factor for surgical failure. Presurgical MERI in children may be a useful tool to determine if patients are candidates for tympanoplasty, more aggressive interventions, or if medical treatment before tympanoplasty is necessary to improve prognosis. When facing a high MERI score, parents and family should be advised before surgery about the possibility of tympanoplasty failure.
Topics: Case-Control Studies; Child; Ear, Middle; Humans; Prognosis; Retrospective Studies; Treatment Outcome; Tympanic Membrane Perforation; Tympanoplasty
PubMed: 33813100
DOI: 10.1016/j.ijporl.2021.110695 -
Head and Neck Pathology Sep 2023
Topics: Humans; Squamous Cell Carcinoma of Head and Neck; Prognosis; Head and Neck Neoplasms
PubMed: 37612573
DOI: 10.1007/s12105-023-01572-8 -
Clinical Oncology (Royal College of... 1997
Topics: Biomarkers, Tumor; Germinoma; Humans; Neoplasm Staging; Prognosis
PubMed: 9315391
DOI: 10.1016/s0936-6555(97)80001-5 -
Clinical Colorectal Cancer Jun 2017Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in the decision-making of adjuvant therapy for patients with stage II disease.
MATERIALS AND METHODS
The aim of this systematic review was to evaluate the prognostic and/or predictive role of MSI status in patients with stage II colorectal cancer on disease-free survival and overall survival. MEDLINE, EMBASE, and Cochrane libraries were searched to identify eligible studies.
RESULTS
Only 2 of 389 articles identified fulfilled the eligibility criteria. In both treated and untreated patients, high-level MSI improved disease-free survival compared with low-level MSI, suggesting a prognostic role but not supporting the hypothesis of a predictive effect of MSI.
CONCLUSIONS
Further studies are needed to explore the predictive role of MSI/mismatch repair proteins, because available data do not allow definitive conclusions.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Clinical Decision-Making; Colorectal Neoplasms; DNA Mismatch Repair; Disease-Free Survival; Humans; Microsatellite Instability; Neoplasm Staging; Prognosis; Survival Rate
PubMed: 27670891
DOI: 10.1016/j.clcc.2016.08.007