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Archives of Toxicology Oct 19754 insecticidal carbamates: 3-methyl, 5-isopropylphenyl N-methyl-carbamate (Promecarb), 4-methylthio, 3,5 dimethylphenyl N-methylcarbamate (Mesurol), 4-dimethyl-amino,...
4 insecticidal carbamates: 3-methyl, 5-isopropylphenyl N-methyl-carbamate (Promecarb), 4-methylthio, 3,5 dimethylphenyl N-methylcarbamate (Mesurol), 4-dimethyl-amino, 3,5 dimethylphenyl N-methylcarbamate (Zectran), and 4-benzothienyl N-methyl-carbamate (Mobam) were orally administered to male Wistar rats. The excretion of the unchanged products was followed in 24 hrs urine collections. The corresponding phenols of the different carbamates could be identified as metabolites by gas-chromatography-mass spectrometyr. These metabolites were quantified afterward by gas-liquid chromatography. In all cases only minor quantities of unchanged products and metabolites were excreted in the urine over the 48 hrs after administration.
Topics: Administration, Oral; Animals; Biotransformation; Carbamates; Chromatography, Gas; Insecticides; Male; Mass Spectrometry; Phenols; Rats
PubMed: 1242891
DOI: 10.1007/BF00353308 -
Patologia Polska 1978
Topics: Anaphylaxis; Animals; Carbamates; Insecticides; Kidney; Lung; Male; Organothiophosphorus Compounds; Rabbits
PubMed: 566415
DOI: No ID Found -
Die Nahrung 1977This method for determining carbamates is based on the inhibiting action of these substances on acetylcholinesterase activity. The use of radioactively labelled...
This method for determining carbamates is based on the inhibiting action of these substances on acetylcholinesterase activity. The use of radioactively labelled acetylcholine as a substrate, the ensuing extractive separation of the radioactive acetic acid (formed by hydrolysis) and its radiometric determination permit to detect very small amounts of carbamates. The limit of detection for aldicarb, baygon, benomyl, bux, carbaryl, CIPC, matacil, phenmedipham and promecarb lies in the picogram range; that for barban and methomyl, in the nanogram range. The lower, linear parts of the curves for the different carbamates fall within the range 0.001-10 ng. The sensitivity (expressed as delta% inhibition/delta lg ng carbamate) ranges from 1.0 to 9.7.
Topics: Aldicarb; Benomyl; Carbaryl; Cholinesterase Inhibitors; Herbicides; Hydrolysis; Insecticides; Methomyl; Radiometry
PubMed: 406567
DOI: 10.1002/food.19770210406