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Pediatrics Aug 1990Promethazine, available by prescription only since its introduction in 1946, has been widely used for pediatric patients because of its antihistaminic, antiemetic, and... (Review)
Review
Promethazine, available by prescription only since its introduction in 1946, has been widely used for pediatric patients because of its antihistaminic, antiemetic, and sedative properties. Recently, it's makers have sought Federal Drug Administration approval to introduce two liquid over the counter allergy/cold/cough products containing promethazine as an active ingredient. Although millions of doses have been administered, promethazine use has not been free of risk. Promethazine has been reported to cause significant sedation, agitation, hallucinations, seizures, dystonic reactions, and possibly apparent life-threatening events or sudden infant death syndrome. The impact of these relatively uncommon adverse reactions on children would be minimal if parents would use over the counter promethazine only for appropriate indications and only in children greater than 2 years of age. However, according to results of research evaluating the use of various over the counter medications by families for their children, promethazine will be used inappropriately. Both its over the counter status, implying a certain margin of safety, and its formulation as a syrup, providing ease of administration, should increase its use in all age groups including that by children less than 2 years of age who may be most vulnerable to the adverse reactions associated with the drug's use.
Topics: Chemistry, Pharmaceutical; Drug Compounding; Drug Prescriptions; Humans; Promethazine
PubMed: 2196521
DOI: No ID Found -
Ugeskrift For Laeger Apr 2017
Topics: Aggression; Antipsychotic Agents; Drug Therapy, Combination; Haloperidol; Humans; Promethazine; Psychotic Disorders
PubMed: 28416057
DOI: No ID Found -
BioMed Research International 2013Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The... (Review)
Review
Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.
Topics: Epidermis; Histamine H1 Antagonists; Humans; Inflammation; Promethazine; Skin Diseases
PubMed: 24350243
DOI: 10.1155/2013/151509 -
Nursing Jul 2020
Topics: Formularies as Topic; Hospitals; Humans; Injections; Promethazine
PubMed: 32558783
DOI: 10.1097/01.NURSE.0000668464.68553.00 -
Prescrire International Oct 2010
Topics: Gangrene; Histamine H3 Antagonists; Humans; Injections, Intravenous; Promethazine
PubMed: 21188805
DOI: No ID Found -
Pediatric Emergency Care Jun 1987The case of a 15-year-old girl who experienced an acute dystonic reaction to promethazine therapy administered during an uncomplicated episode of acute gastroenteritis...
The case of a 15-year-old girl who experienced an acute dystonic reaction to promethazine therapy administered during an uncomplicated episode of acute gastroenteritis is reported. The pertinent literature is reviewed.
Topics: Acute Disease; Adolescent; Dystonia; Female; Gastroenteritis; Humans; Promethazine; Suppositories; Vomiting
PubMed: 3615241
DOI: 10.1097/00006565-198706000-00007 -
Biofouling Feb 2023spp. are emerging opportunistic fungi associated with invasive infections, especially in patients with haematological malignancies. The present study investigated the...
spp. are emerging opportunistic fungi associated with invasive infections, especially in patients with haematological malignancies. The present study investigated the inhibition of efflux pumps by promethazine (PMZ) as a strategy to control and . Planktonic cells were evaluated for antifungal susceptibility to PMZ, as well as inhibition of efflux. The effect of PMZ was also studied in biofilms. PMZ inhibited and planktonic cells at concentrations ranging from 32 to 256 μgml. Subinhibitory concentrations of PMZ inhibited efflux activity in . Biofilms were completely eradicated by PMZ. PMZ potentiated the action of antifungals, affected the morphology, changed the amount of carbohydrates and proteins and reduced the amount of persister cells inside biofilms. The results showed indirect evidences of the occurrence of efflux pumps in and opens a perspective for the use of this target in the control of trichosporonosis.
Topics: Humans; Antifungal Agents; Trichosporon; Promethazine; Biofilms; Plankton; Microbial Sensitivity Tests
PubMed: 37122169
DOI: 10.1080/08927014.2023.2202315 -
The American Journal of Nursing Apr 2024
Topics: Humans; Promethazine
PubMed: 38511703
DOI: 10.1097/01.NAJ.0001010556.28403.79 -
The Journal of the Medical Society of... Feb 1960
Topics: Female; Humans; Labor, Obstetric; Obstetrics; Pregnancy; Promethazine; Work
PubMed: 14430162
DOI: No ID Found -
Singapore Medical Journal Mar 1970
Topics: Adolescent; Adult; Drug Eruptions; Female; Humans; Photosensitivity Disorders; Promethazine
PubMed: 4246712
DOI: No ID Found