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Molecules (Basel, Switzerland) Apr 2021Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer's...
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer's disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design and synthesis of a novel [C]promethazine PET radioligand for future in vivo studies. The [C]promethazine was isolated by RP-HPLC with radiochemical purity >95% and molar activity of 48 TBq/mmol. The specificity of the probe was demonstrated using human hippocampal tissues via autoradiography.
Topics: Alzheimer Disease; Animals; Autoradiography; Brain; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Promethazine; Radiochemistry; Radiopharmaceuticals
PubMed: 33920113
DOI: 10.3390/molecules26082182 -
Journal of the American Medical... Jan 1959
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Obstetrics; Pregnancy; Promethazine
PubMed: 13610624
DOI: 10.1001/jama.1959.03000180007002 -
Archives of Biochemistry and Biophysics Aug 2000The effect of promethazine on peroxidase-catalyzed oxidation of 3,3', 5,5'-tetramethylbenzidine was investigated at pH 5.4. Promethazine dose dependently introduced a...
The effect of promethazine on peroxidase-catalyzed oxidation of 3,3', 5,5'-tetramethylbenzidine was investigated at pH 5.4. Promethazine dose dependently introduced a lag in the appearance of tetramethylbenzidine charge-transfer complex monitored at 652 nm. Increasing concentrations of tetramethylbenzidine however decreased the lag period proportional to the tetramethylbenzidine concentration. Addition of promethazine to preformed charge transfer complex caused rapid bleaching of the blue-colored complex. Titration of promethazine with the yellow-colored diimine gave rise to the blue charge-transfer complex and the complete reduction of the species to the colorless parent amine compound. The available evidence suggests that promethazine is oxidized via redox mediation by tetramethylbenzidine peroxidase-oxidized products.
Topics: Benzidines; Horseradish Peroxidase; Humans; In Vitro Techniques; Kinetics; Oxidation-Reduction; Peroxidase; Peroxidases; Promethazine; Substrate Specificity
PubMed: 10933879
DOI: 10.1006/abbi.2000.1710 -
The American Journal of Emergency... May 2010
Topics: Adult; Anti-Allergic Agents; Emergency Medical Services; Humans; Injections, Intravenous; Male; Middle Aged; Promethazine
PubMed: 20466253
DOI: 10.1016/j.ajem.2009.04.013 -
Neuropsychobiology 1984Diazepam 5 mg, promethazine 25 mg, propiomazine 25 mg, and placebo as sleeping aids were studied in 40 elderly inpatients. The drugs were administered in a random order,... (Comparative Study)
Comparative Study
Diazepam 5 mg, promethazine 25 mg, propiomazine 25 mg, and placebo as sleeping aids were studied in 40 elderly inpatients. The drugs were administered in a random order, double-blind, on 21 nights. All active drugs were found effective in the mentally normal elderly, but in the psychogeriatric group of 20 patients, only propiomazine very significantly reduced the number of nocturnal awakenings and only diazepam almost significantly shortened the initial sleep latency, although duration of sleep was prolonged in both groups. There was neither loss of efficacy of the trial drugs nor rebound on withdrawal. Psychomotor skills and serum prolactin levels remained unaffected.
Topics: Aged; Diazepam; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Phenothiazines; Promethazine; Random Allocation; Sleep Initiation and Maintenance Disorders
PubMed: 6152029
DOI: 10.1159/000118126 -
Journal of Clinical Pharmacology Jun 1994In an earlier study, the authors found that severely motion sick individuals could be greatly relieved of their symptoms by intramuscular injections of promethazine (50...
In an earlier study, the authors found that severely motion sick individuals could be greatly relieved of their symptoms by intramuscular injections of promethazine (50 mg) or scopolamine (.5 mg). Comparable 50-mg injections of promethazine also have been found effective in alleviating symptoms of space motion sickness. The concern has risen, however, that such drugs may delay or retard the acquisition of adaptation to stressful environments. In the current study, we controlled arousal using a mental arithmetic task and precisely equated the exposure history (number of head movements during rotation) of a placebo, control group and an experimental group who had received promethazine. No differences in total adaptation or in rates of adaptation were present between the two groups. Another experimental group also received promethazine and was allowed to make as many head movements as they could, before reaching nausea, up to 800. This group showed a greater level of adaptation than the placebo group. These results suggest a strategy for dealing with space motion sickness that is described.
Topics: Adaptation, Physiological; Adult; Arousal; Head; Humans; Male; Mental Processes; Motion Sickness; Movement; Promethazine; Rotation
PubMed: 8083396
DOI: 10.1002/j.1552-4604.1994.tb02018.x -
The Journal of the Medical Society of... Jun 1958
Topics: Anesthesia; Anesthesiology; Promethazine
PubMed: 13549953
DOI: No ID Found -
British Medical Journal Jul 1960
Topics: Dermatitis, Phototoxic; Humans; Photosensitivity Disorders; Promethazine
PubMed: 14426802
DOI: 10.1136/bmj.2.5195.359 -
Zhonghua Er Ke Za Zhi = Chinese Journal... Jul 2010
Topics: Contraindications; Humans; Infant; Infant, Newborn; Promethazine
PubMed: 21055103
DOI: No ID Found -
Journal of Perianesthesia Nursing :... Feb 2015To compare the use of promethazine 6.25 mg intravenous (IV) (experimental group) with promethazine 12.5 mg IV (control group) among adult ambulatory surgery patients to... (Comparative Study)
Comparative Study Randomized Controlled Trial
PURPOSE
To compare the use of promethazine 6.25 mg intravenous (IV) (experimental group) with promethazine 12.5 mg IV (control group) among adult ambulatory surgery patients to control established postoperative nausea or vomiting (PONV).
DESIGN/METHODS
In a double-blind, randomized controlled trial (n = 120), 59 subjects received promethazine 6.25 mg and 61 subjects received promethazine 12.5 mg to treat PONV. Study doses were administered postoperatively if the subject reported/exhibited nausea and/or vomiting. Outcomes for experimental and control groups were compared on the basis of relief of PONV and sedation levels.
FINDINGS
Ninety-seven percent of subjects reported total relief of nausea with a single administration of promethazine at either dose. Sedation levels differed between groups at 30 minutes post-medication administration and at the time of discharge to home.
CONCLUSIONS
Promethazine 6.25 mg is as effective in controlling PONV as promethazine 12.5 mg, while resulting in less sedation.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Postoperative Nausea and Vomiting; Promethazine
PubMed: 25616881
DOI: 10.1016/j.jopan.2014.01.009