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The Annals of Pharmacotherapy 2005
Topics: Antiemetics; Dose-Response Relationship, Drug; Drug Interactions; Humans; Postoperative Nausea and Vomiting; Promethazine
PubMed: 15956221
DOI: 10.1345/aph.1E361a -
Research in Veterinary Science Apr 1999The pharmacokinetics of promethazine were determined in seven camels (Camelus dromedarius) after an intravenous dose of 0.5 mg kg body weight.-1 The data obtained...
The pharmacokinetics of promethazine were determined in seven camels (Camelus dromedarius) after an intravenous dose of 0.5 mg kg body weight.-1 The data obtained (median and range) were as follows: the elimination half-life (t1/2 beta) was 5.62 (2.84-6.51) h; the steady state volume of distribution (Vdss) was 8.90 (7.10-12.00) L kg-1, total body clearance (CT) was 24.5 (17.22-33.65) ml kg-1 min-1 and renal clearance (Clr) was 4.81 (1.97-5.48) ml kg-1 min-1.
Topics: Animals; Camelus; Half-Life; Histamine H1 Antagonists; Injections, Intravenous; Male; Metabolic Clearance Rate; Promethazine
PubMed: 10208894
DOI: 10.1053/rvsc.1998.0255 -
Canadian Medical Association Journal Jun 1984Two cases in which dermal absorption of promethazine hydrochloride resulted in a toxic neurologic syndrome are reported. The symptoms included central nervous system...
Two cases in which dermal absorption of promethazine hydrochloride resulted in a toxic neurologic syndrome are reported. The symptoms included central nervous system depression, acute excitomotor manifestations, ataxia and visual hallucinations. In addition, peripheral anticholinergic effects occurred. These symptoms are comparable with those of oral, intramuscular and rectal overdose of promethazine. The demonstrated risks of the topical use of promethazine outweigh any benefits.
Topics: Administration, Topical; Akathisia, Drug-Induced; Ataxia; Child, Preschool; Diazepam; Eczema; Female; Hallucinations; Humans; Infant; Male; Promethazine; Skin Absorption
PubMed: 6733616
DOI: No ID Found -
Journal of Emergency Nursing Feb 2007
Topics: Adult; Drug Administration Routes; Female; Gangrene; Histamine H1 Antagonists; Humans; Injections, Intravenous; Male; Promethazine
PubMed: 17258055
DOI: 10.1016/j.jen.2006.09.009 -
Anaesthesia Jan 1961
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Humans; Methohexital; Pain Management; Preoperative Care; Promethazine; Thiopental
PubMed: 13772305
DOI: 10.1111/j.1365-2044.1961.tb13375.x -
European Journal of Drug Metabolism and... 1988Co-administration of promethazine hydrochloride and chloroquine phosphate resulted in increased blood levels of chloroquine and its metabolites. However, there is no...
Co-administration of promethazine hydrochloride and chloroquine phosphate resulted in increased blood levels of chloroquine and its metabolites. However, there is no statistical difference between the means obtained for the initial rate of excretion and the total drug excreted within three hours.
Topics: Adult; Chloroquine; Female; Humans; Male; Promethazine
PubMed: 3396608
DOI: 10.1007/BF03189922 -
Biomedical Chromatography : BMC Jan 2003The interaction of carbamazepine and promethazine in rabbits has been investigated. The influence of this interaction on the processes of biotransformation in the liver...
The interaction of carbamazepine and promethazine in rabbits has been investigated. The influence of this interaction on the processes of biotransformation in the liver was revealed. The drugs were administered as single oral doses (100 mg of each drug) as well as simultaneously with an interval of 15 min. The sequence of administration of the drugs was varied. The influence of promethazine on the pharmacokinetics of carbamazepine is expressed by: (a) strong suppression of carbamazepine's level in plasma and appearance of multiple peaks of carbamazepine; (b) suppression of biotransformation of carbamazepine into carbamazepine-10,11-epoxide at the initial stages and its increase in the intermediate stages. These data are explained by the active capture of carbamazepine by liver at its primary transferal through the liver and sufficient presystem elimination of carbamazepine in the presence of promethazine. The character of kinetic curves of promethazine varies substantially under the influence of carbamazepine. However, this change is not as strong as in case of carbamazepine. The concentration of promethazine in plasma varies slightly and multiple peaks are not observed. The rate of terminal elimination of promethazine varies and abrupt prolonged segments of elimination appear at the initial and terminal stages of the process in return. These data perhaps indicate the induction of biotransformation of promethazine in the presence of carbamazepine-an inductor of microsomal liver enzymes. The changes of kinetics of promethazine and carbamazepine by simultaneous administration as compared with their administration separately, as well as a comparative consideration of pharmacokinetics of promethazine and carbamazepine by simultaneous administration show the existence of competition in the elimination between these drugs and the periodic saturation of liver for their biotransformation.
Topics: Animals; Biotransformation; Carbamazepine; Drug Interactions; Promethazine; Rabbits
PubMed: 12583009
DOI: 10.1002/bmc.209 -
Pediatrics Aug 1991
Topics: Administration, Intranasal; Humans; Infant; Nonprescription Drugs; Promethazine; Sudden Infant Death
PubMed: 1861957
DOI: No ID Found -
Rocky Mountain Medical Journal Aug 1958
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Child; Humans; Pain Management; Pentobarbital; Promethazine; Tonsillectomy
PubMed: 13568553
DOI: No ID Found -
Journal of Chromatography. B,... Nov 2001A chromatographic method for the quantitation of promethazine (PMZ) and its three metabolites in urine employing on-line solid-phase extraction and column-switching has...
A chromatographic method for the quantitation of promethazine (PMZ) and its three metabolites in urine employing on-line solid-phase extraction and column-switching has been developed. The column-switching system described here uses an extraction column for the purification of PMZ and its metabolites from a urine matrix. The extraneous matrix interference was removed by flushing the extraction column with a gradient elution. The analytes of interest were then eluted onto an analytical column for further chromatographic separation using a mobile phase of greater solvent strength. This method is specific and sensitive with a range of 3.75-1400 ng/ml for PMZ and 2.5-1400 ng/ml for the metabolites promethazine sulfoxide, monodesmethyl promethazine sulfoxide and monodesmethyl promethazine. The lower limits of quantitation (LLOQ) were 3.75 ng/ml with less than 6.2% C.V. for PMZ and 2.50 ng/ml with less than 11.5% C.V. for metabolites based on a signal-to-noise ratio of 10:1 or greater. The accuracy and precision were within +/- 11.8% in bias and not greater than 5.5% C.V. in intra- and inter-assay precision for PMZ and metabolites. Method robustness was investigated using a Plackett-Burman experimental design. The applicability of the analytical method for pharmacokinetic studies in humans is illustrated.
Topics: Humans; Promethazine; Reproducibility of Results; Sensitivity and Specificity
PubMed: 11710587
DOI: 10.1016/s0378-4347(01)00351-6