-
Journal of Pharmaceutical Sciences Jun 1987A bioequivalence study of promethazine hydrochloride (10-[2-(dimethylamino)propyl]-phenothiazine monohydrochloride) was conducted in 20 male human subjects with the...
A bioequivalence study of promethazine hydrochloride (10-[2-(dimethylamino)propyl]-phenothiazine monohydrochloride) was conducted in 20 male human subjects with the purpose of comparing, under blind condition, the human serum levels of promethazine in three different formulations. The formulations tested were a 50-mg promethazine hydrochloride polyethylene glycol suppository, a 50-mg promethazine hydrochloride cocoa butter-white wax suppository, and a 50-mg oral dose of promethazine hydrochloride syrup. Each subject received single doses of each of the three formulations on each of three different days on a crossover basis. From the measured serum levels, estimates of the bioavailability parameters (area under the serum concentration versus time curve, time-to-peak serum concentration, and peak serum concentration) were obtained by least-squares digital computer fitting. Also, a one-compartment pharmacokinetic open model with two consecutive first-order input steps is proposed. Statistical analysis of the results was performed by using a linear multiple regression approach for the analysis of variance. No significant differences between the syrup and the polyethylene glycol suppositories were obtained (p greater than 0.05) for the above three bioavailability parameters. However, the polyethylene glycol suppositories provided statistically higher peak serum concentration, shorter time-to-peak serum concentration, and larger area under the serum concentration versus time curve than the cocoa butter-white wax suppositories.
Topics: Adult; Humans; Kinetics; Male; Metabolic Clearance Rate; Promethazine; Suppositories; Therapeutic Equivalency
PubMed: 3625487
DOI: 10.1002/jps.2600760606 -
El Dia Medico Nov 1957
Topics: Measles; Promethazine
PubMed: 13490183
DOI: No ID Found -
Clinical Chemistry Feb 1981We describe a procedure for the liquid-chromatographic determination of promethazine in low-nanogram concentrations in serum. Triflupromazine is used as the internal...
We describe a procedure for the liquid-chromatographic determination of promethazine in low-nanogram concentrations in serum. Triflupromazine is used as the internal standard. The method is based on a single extraction of promethazine from serum with hexane and subsequent derivatization with trichloroethyl chloroformate. Analytical recovery of promethazine is about 90%. The lower limit of detection is 1 microgram/L when a 2.0-mL aliquot of serum is assayed. Our data illustrate the practicability of the method for bioavailability studies after oral or rectal administration of promethazine hydrochloride.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Microchemistry; Promethazine; Rectum
PubMed: 7460275
DOI: No ID Found -
Journal of Pharmaceutical Sciences Jan 1967
Topics: Chromatography; Infrared Rays; Promethazine; Solutions; Spectrophotometry; Ultraviolet Rays
PubMed: 6030503
DOI: 10.1002/jps.2600560120 -
CMAJ : Canadian Medical Association... Apr 1987
Topics: Female; Humans; Labor, Obstetric; Maternal-Fetal Exchange; Pregnancy; Promethazine
PubMed: 3828921
DOI: No ID Found -
Journal of Pharmaceutical Sciences Jun 1983A spectrophotometric method was developed for determining promethazine hydrochloride (I) complexed with bromcresol green and then extracted with chloroform. The complex...
A spectrophotometric method was developed for determining promethazine hydrochloride (I) complexed with bromcresol green and then extracted with chloroform. The complex in chloroform showed maximum absorption at 415 nm and obeyed Beer's law over 1.2-8.5 micrograms/ml. The complex molar absorptivity was 1.93 X 10(4) M. Complex formation and extraction were complete and quantitative over pH 2.7-2.8. The promethazine hydrochloride-bromcresol green molar ratio was 1:1. Excipients, coloring matter, flavoring agents, and other substances likely to be present in promethazine preparations did not interfere in the determination. Direct determination in tablet, syrup, and injection preparations were carried out satisfactorily.
Topics: Bromcresol Green; Chemical Phenomena; Chemistry; Promethazine; Solutions; Tablets
PubMed: 6875836
DOI: 10.1002/jps.2600720629 -
American Journal of Diseases of... Oct 1980
Topics: Basal Ganglia Diseases; Child, Preschool; Dystonia; Female; Humans; Promethazine
PubMed: 7424860
DOI: 10.1001/archpedi.1980.02130220066020 -
Spectrochimica Acta. Part A, Molecular... May 2019Knowledge of binding parameters for drug and surfactant complexations is crucially vital in order to design effective drug carrier systems with requisite features. To...
Biophysical investigation of promethazine hydrochloride binding with micelles of biocompatible gemini surfactants: Combination of spectroscopic and electrochemical analysis.
Knowledge of binding parameters for drug and surfactant complexations is crucially vital in order to design effective drug carrier systems with requisite features. To this end, this work was designed to demonstrate the biophysical characterization of the interaction of a phenothiazine drug promethazine hydrochloride (PMT) with relatively lower cytotoxic and easily degradable biomimetic micellar self-assemblies of oxy-diester functionalized gemini surfactants (C-E2O-C, m = 12, 14 and 16), possessing different hydrophobic character. The binding propensity of C-E2O-C increases upon increasing the hydrophobic tail length as manifested through both intrinsic fluorescence and absorption spectral profiles of PMT ̶ C-E2O-C, showing 1:1 stoichiometry. K values also follow the trend of increasing hydrophobic character (i.e., C-E2O-C < C-E2O-C < C-E2O-C). Moreover, the determined thermodynamic parameters, particularly the positive values of ΔH and ΔS, reveal that the involved complexations are dominated by the hydrophobic interactions. In addition, micropolarity assay was done to deduce the microenvironmental changes upon PMT ̶ C-E2O-C complexations. Beside this, comparative appraisal of all the three systems helps to underpin a reasonable knowledge of the effect of structural variation of surfactants on their binding ability with drug which, in turn, may also open new avenues for the designing of potential tunable drug carrier systems.
Topics: Biophysical Phenomena; Electrochemical Techniques; Hydrophobic and Hydrophilic Interactions; Micelles; Promethazine; Pyrenes; Quaternary Ammonium Compounds; Spectrometry, Fluorescence; Surface-Active Agents
PubMed: 30831395
DOI: 10.1016/j.saa.2019.02.082 -
Pediatric Dentistry Mar 1985
Comparative Study
Topics: Anesthesia, Dental; Child Behavior; Child, Preschool; Chloral Hydrate; Humans; Hypnotics and Sedatives; Infant; Preanesthetic Medication; Promethazine
PubMed: 3857559
DOI: No ID Found -
Anesthesiology 1961
Topics: Humans; Meperidine; Promethazine
PubMed: 13752107
DOI: 10.1097/00000542-196101000-00008