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Archives Internationales de... Oct 1960
Topics: 1-Propanol; Biperiden; Parasympatholytics; Propanols
PubMed: 13710192
DOI: No ID Found -
Journal of Biochemical Toxicology 1991
Review
Topics: 1-Propanol; Animals; Liver; Liver Circulation; Propanols
PubMed: 1880785
DOI: 10.1002/jbt.2570060102 -
Bioorganic & Medicinal Chemistry Letters Aug 2005Novel 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl]amino-1-propanol hydrochlorides were designed based on the pharmacophore for potent uterine... (Comparative Study)
Comparative Study
Novel 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl]amino-1-propanol hydrochlorides were designed based on the pharmacophore for potent uterine relaxant activity and by utilizing the principles of structural hybridization. The designed molecules were synthesized as racemates by a novel route and were evaluated for uterine relaxant activity in vitro on isolated rat uterus and in vivo in pregnant rats. Their cAMP-releasing potential was studied using rat uterus tissue homogenates by the cAMP [(3)H] assay, and cardiac stimulant potential was evaluated on isolated guinea pig right atrium. All compounds exhibited potent uterine relaxant activity in vitro and produced a significant delay in the onset of labour in pregnant rats; their cAMP-releasing potential was slightly less, while their cardiac stimulant potential was insignificant as compared to isoxsuprine hydrochloride.
Topics: 1-Propanol; Animals; Cardiotonic Agents; Cyclic AMP; Drug Design; Female; Isoxsuprine; Muscle Relaxation; Pregnancy; Rats; Uterus
PubMed: 15967663
DOI: 10.1016/j.bmcl.2005.05.047 -
The Journal of Organic Chemistry Jul 1947
Topics: 1-Propanol; 2-Propanol; Benzyl Alcohols; Propanols
PubMed: 20253216
DOI: 10.1021/jo01168a003 -
Archives of Neurology Jan 1991
Topics: 1-Propanol; Alcoholic Intoxication; Humans
PubMed: 1986719
DOI: 10.1001/archneur.1991.00530130026007 -
Spectrochimica Acta. Part A, Molecular... Sep 2008The molecular interactions of pyrazine (PZ) with n-propanol, chloroform, and tetrahydrofuran (THF) have been investigated by employing ultraviolet spectroscopy and...
The molecular interactions of pyrazine (PZ) with n-propanol, chloroform, and tetrahydrofuran (THF) have been investigated by employing ultraviolet spectroscopy and quantum chemical calculation methods. A new quantity, excess absorption coefficient, was introduced to represent the strength of the interaction. It was found that the interaction decreased in the order: PZ-propanol>PZ-chloroform>PZ-THF. The Benesi-Hildebrand method indicated that the interaction stoichiometries of the PZ-chloroform and PZ-THF systems were both 1:1 and the equilibrium constants were determined to be 2.07 and 0.64M(-1), respectively. Using a nonlinear fitting method, we demonstrated that the PZ-propanol was a two-step 1:2 interaction pair and the equilibrium constants were determined to be 8.8 and 0.19M(-1). Quantum chemical calculations showed the existence of hydrogen-bonding interactions in all the three system: normal Ncdots, three dots, centeredH-O hydrogen bond in the PZ-propanol system, unconventional Ncdots, three dots, centeredH-C hydrogen bond in the PZ-chloroform, and weak N-C-Hcdots, three dots, centeredO hydrogen bond in the PZ-THF system. Methodologically, we pointed out that special care must be taken when the Benesi-Hildebrand method is used to evaluate 1:2 interactions.
Topics: 1-Propanol; Chloroform; Furans; Models, Molecular; Molecular Structure; Pyrazines; Spectrophotometry
PubMed: 18006373
DOI: 10.1016/j.saa.2007.09.014 -
Journal of Molecular Biology Aug 1984X-ray diffraction data of collagen molecules modified with 2-propanol favour a quasi-hexagonal lateral packing over a quasi-tetragonal one.
X-ray diffraction data of collagen molecules modified with 2-propanol favour a quasi-hexagonal lateral packing over a quasi-tetragonal one.
Topics: 1-Propanol; Collagen; Macromolecular Substances; X-Ray Diffraction
PubMed: 6481806
DOI: 10.1016/0022-2836(84)90051-2 -
The Journal of Biological Chemistry Apr 1957
Topics: 1-Propanol; Corrinoids; Propanolamines; Propanols; Streptomyces; Threonine; Vitamin B 12
PubMed: 13416277
DOI: No ID Found -
Journal of Proteomics Mar 2024Buffalo is a silent heat animal and doesn't show prominent signs of estrous like cattle so it becomes difficult for farmers to determine the receptivity of the animal...
Buffalo is a silent heat animal and doesn't show prominent signs of estrous like cattle so it becomes difficult for farmers to determine the receptivity of the animal based purely on the animal behaviour. India, having a huge population size, needs to produce more milk for the population. Successful artificial insemination greatly depends on the receptivity of the animal. Hence the present study aimed to identify the changes in the metabolome of the buffalo. GC-MS based mass spectrometric analysis was deployed for the determination of estrous by differential expression of metabolites. It was found that hydracrylic acid, 3-bromo-1-propanol and benzyl serine were significantly upregulated in the estrous phase of buffalo (p.value ≤0.05, FC ≥ 2). The pathway enrichment analysis also supported the same as pathways related to amino acid metabolism and fatty acid metabolism were up regulated along with the Warburg effect which is linked to the rapid cell proliferation which might help prepare animals to meet the energy requirement during the estrous. Further analysis of the metabolic biomarkers using ROC analysis also supported these three metabolites as probable biomarkers as they were identified with AUC values of 0.7 or greater. SIGNIFICANCE: The present study focuses on the untargeted metabolomics studies of buffalo urine with special reference to the estrous phase of reproductive cycle. The estrous signals are more prominent in cattle, where animals show clear estrous signals such as mounting and discharge along with vocal signals. Buffalo is a silent heat animal and it becomes difficult for farmers to detect the estrous based on the physical and behavioral signals. Hence the present study focuses on GC-MS based untargeted metabolomics to identify differentially expressed urine metabolites. In this study, hydracrylic acid, 3-bromo-1-propanol and benzyl serine were found to be significantly upregulated in the estrous phase of buffalo (p-value ≤0.05, FC ≥ 2). Further confirmation of the metabolic biomarkers was done using Receiver operating characteristics (ROC) analysis which also supported these three metabolites as probable biomarkers as they had AUC values of 0.7 or greater. Hence, this study will be of prime importance for the people working in the area of animal metabolomics.
Topics: Humans; Female; Animals; Cattle; 1-Propanol; Serine; Estrus; Metabolomics; Biomarkers; Metabolome; Propanols; Lactic Acid
PubMed: 38364903
DOI: 10.1016/j.jprot.2024.105124 -
Analytical Biochemistry May 2024To investigate the solvent effect on the detection of peptides and proteins, nanoelectrospray mass spectra were measured for mixtures of 1 % acetic acid and...
To investigate the solvent effect on the detection of peptides and proteins, nanoelectrospray mass spectra were measured for mixtures of 1 % acetic acid and 5 × 10 M gramicidin S (G), ubiquitin (U), and cytochrome c (C) in water (W), methanol (MeOH), 1-propanol (1-PrOH), acetonitrile (AcN), and 2-propanol (2-PrOH). Although doubly protonated G (G2+) and multiply protonated U (Un+) and C (Cn+) were readily detected with a wide range of mixing ratios of W solutions for MeOH, 1-PrOH, and AcN, Cn+ was totally suppressed for the solutions with mixing ratios (v/v) of W/2-PrOH (50/50) and (70/30). However, denatured Cn+ started to be detected with W/2-PrOH (90/10) together with Gn+ (n = 1, 2) and native Un+ (n = 6-8). At the mixing ratio of W/2-PrOH (95/5), native Cn+ (n = 7-10) together with Gn+ (n = 1, 2) and native Un+ (n = 6-8) were detected with high ion intensities. The use of W/2-PrOH (95/5) is profitable because it enables the detection of native proteins with high detection sensitivities.
Topics: Solvents; 1-Propanol; 2-Propanol; Proteins; Mass Spectrometry; Peptides; Water; Methanol
PubMed: 38244751
DOI: 10.1016/j.ab.2024.115461