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Canadian Journal of Physiology and... Nov 1964
Topics: 1-Propanol; Alcoholic Intoxication; Alcohols; Animals; Blood; Blood Pressure; Butanols; Dogs; Electrocardiography; Ethanol; Heart Rate; Propanols; Pulse; Research; Toxicology
PubMed: 14324201
DOI: 10.1139/y64-078 -
Biochemical Pharmacology Oct 1981
Topics: 1-Propanol; Acrolein; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Aldehydes; Biotransformation; Glutathione; Kinetics; Liver; Nitrites; Propanols
PubMed: 7028044
DOI: 10.1016/0006-2952(81)90545-1 -
Regulatory Toxicology and Pharmacology... Jun 1996The toxicity of isopropanol (IPA) has been extensively studied as a result of a Test Rule under Section 4 of the Toxic Substances Control Act. In general, the data... (Review)
Review
The toxicity of isopropanol (IPA) has been extensively studied as a result of a Test Rule under Section 4 of the Toxic Substances Control Act. In general, the data showed that IPA has a low order of acute and chronic toxicity; does not produce adverse effects on reproduction; is neither a teratogen, a selective developmental toxicant, nor a developmental neurotoxicant; and is not genotoxic or an animal carcinogen. IPA is, however, a potential hazard for transient central nervous system depression at high exposure levels. In addition, IPA produced effects to several rodent toxicity endpoints at high dose levels (i.e., motor activity, male mating index, and exacerbated renal disease) which are of unclear relevance to human health. The data generated by these studies confirmed that IPA acts as a typical short-chain alcohol in mammalian biological systems. It produces a significant narcotic effect upon exposure at high levels for extended periods of time, with no irreversible effects even after repeated exposure, which is consistent with other short-chain alcohols. The metabolism of IPA appears equivalent across species with rapid conversion to acetone and carbon dioxide. Overall, these studies demonstrate IPA exposure is a low potential hazard to human health. This information will allow for an improved assessment of the human health risks from IPA exposure.
Topics: 1-Propanol; Administration, Inhalation; Animals; Behavior, Animal; Embryonic and Fetal Development; Female; Injections, Intravenous; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Rats; Reproduction; Species Specificity; Toxicity Tests
PubMed: 8812960
DOI: 10.1006/rtph.1996.0042 -
Acta Crystallographica. Section C,... Aug 1996The asymmetric unit (C17H25N3O5.C3H8O.2H2O) consists of two crystallographically independent peptide molecules, A and B, with different conformations, chi 1(2) being...
The asymmetric unit (C17H25N3O5.C3H8O.2H2O) consists of two crystallographically independent peptide molecules, A and B, with different conformations, chi 1(2) being trans and gauche- for the Leu residues in molecules A and B, respectively. The backbone conformation of both peptide molecules resembles that of the beta-pleated sheet arrangement found in proteins. Comparison with two other structures containing the tripeptide Gly-L-Leu-L-Tyr reveals almost identical molecular conformations, and in one instance also a common packing pattern.
Topics: 1-Propanol; Crystallography, X-Ray; Oligopeptides; Protein Conformation
PubMed: 8819306
DOI: 10.1107/s0108270196002041 -
The Journal of Physical Chemistry. B Jan 2023We present a dielectric and shear mechanical study of 1-propanol and three phenylpropanols. Contrary to other monoalcohols, the phenylpropanols do not show a bimodal...
We present a dielectric and shear mechanical study of 1-propanol and three phenylpropanols. Contrary to other monoalcohols, the phenylpropanols do not show a bimodal behavior in their dielectric response, but instead show a single, rather narrow process. Combined dielectric and light scattering spectra (Böhmer, T.; et al. 2019, 123, 10959) have shown that this single peak may be separated into a self- and a cross-correlation part, thus indicating that phenylpropanols do display features originating from hydrogen-bonded structures. The shear mechanical spectra support that interpretation, demonstrating a subtle, yet clear, low-frequency polymer-like mode, similar to what is found in other monoalcohols. An analysis of the characteristic time scales found in the spectra shows that shear alpha relaxation is faster than the dielectric alpha and that time scale separation of the dielectric Debye and alpha processes is temperature and nearly identical in all the phenylpropanols.
Topics: 1-Propanol; Temperature; Hydrogen
PubMed: 36563319
DOI: 10.1021/acs.jpcb.2c07120 -
World Journal of Microbiology &... Feb 2024The preservation of drug stability in biological evidence during the processes of collection and storage poses a substantial obstacle to the progress of forensic...
Evaluation of stability of (1R,2 S)-(-)-2-methylamino-1-phenyl-1-propanol hydrochloride in plasma and urine samples-inoculated with Escherichia coli using high-performance liquid chromatography (HPLC).
The preservation of drug stability in biological evidence during the processes of collection and storage poses a substantial obstacle to the progress of forensic investigations. In conjunction with other constituents, the microorganisms present in the samples play a vital role in this investigation. The present investigation employed the high-performance liquid chromatography (HPLC) technique to assess the stability of (1R,2 S)-(-)-2-methylamino-1-phenyl-1-propanol hydrochloride in plasma and urine samples that were inoculated with Escherichia coli. These samples were subjected to storage conditions of 37 °C for 48 h and - 20 °C for a duration of 6 months. Minimal inhibitory concentration (MIC) and Minimal bactericidal concentration (MBC) of MPPH against E. coli were determined using microdilution method. The stability of MPPH in plasma and urine samples inoculated with E. coli was investigated using HPLC method. The results showed the MIC and MBC of MPPH were 87.5 ± 25 ppm and 175 ± 50 ppm, respectively. While MPPH remained stable in plasma for 48 h at 37 °C, it showed a notable decrease of about 11% in stability when stored in urine for the same period and temperature. From the beginning of the first month, a decrease in the stability of the compound appeared in all samples that were stored at - 20 °C, and the decrease reached 7% for plasma samples and about 11% for urine samples. The decrease in the stability reached its peak in the sixth month, reaching more than 30% and 70% of plasma and urine samples preserved at - 20 °C. This work concluded that E. coli can negatively affect the stability of MPPH in plasma and urine samples. This may lead to incorrect conclusions regarding the analysis of biological samples in criminal cases.
Topics: Chromatography, High Pressure Liquid; Escherichia coli; 1-Propanol; 2-Propanol; Microbial Sensitivity Tests
PubMed: 38349591
DOI: 10.1007/s11274-024-03890-7 -
Spectrochimica Acta. Part A, Molecular... Sep 2011The toxic interaction of methanol, ethanol and propanol with bovine hemoglobin (BHb) at protein molecular level was studied by resonance light scattering (RLS),...
The toxic interaction of methanol, ethanol and propanol with bovine hemoglobin (BHb) at protein molecular level was studied by resonance light scattering (RLS), fluorescence, ultraviolet-visible absorption (UV-vis) and circular dichroism (CD) techniques. The experimental results showed that the three alcohols all had toxic effects on BHb and the effects increased along with the increasing alcohol dose. The results of RLS and fluorescence spectroscopy showed that alcohols can denature BHb. They changed the microenvironment of amino acid residues and led to molecular aggregation. The decreasing order of the influence is propanol, ethanol and methanol. The results of UV-vis and CD spectra revealed that alcohols led to conformational changes of BHb, including the loosening of the skeleton structure and the decreasing of α-helix in the second structure. The changes generated by propanol were much larger than those by methanol and ethanol.
Topics: 1-Propanol; Animals; Cattle; Circular Dichroism; Ethanol; Hemoglobins; Methanol; Models, Molecular; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet
PubMed: 21646043
DOI: 10.1016/j.saa.2011.04.076 -
Drug Metabolism and Drug Interactions 1989The more recent experimental works on the chemistry, industrial uses and general toxicity (with particular reference to liver cell injury) of allyl alcohol (AA) have... (Review)
Review
The more recent experimental works on the chemistry, industrial uses and general toxicity (with particular reference to liver cell injury) of allyl alcohol (AA) have been briefly reviewed. AA is inactive per se and its toxic expression is modulated by its alcohol dehydrogenase (ADH) oxidation to form acrolein, which is responsible for the hepatotoxic action. The toxicity of the alcohol (or its metabolite acrolein) is dependent on the concentration of glutathione (GSH). After severe depletion of GSH, the reactive metabolite of AA can bind to essential sulfhydryl groups in the cellular macromolecules, leading to structural and functional modifications which can be responsible for cell death. In this case the appearance of lipid peroxidation could be merely the consequence of the death. GSH synthesis precursors exert a protective role in AA intoxication. The significance of calcium modifications in the course of AA toxicity is still under debate.
Topics: 1-Propanol; Animals; Humans; Propanols
PubMed: 2489200
DOI: No ID Found -
Journal of Toxicology and Environmental... Feb 1995Glycidol (2,3-epoxy-1-propanol), an industrial chemical, has been shown to be a reproductive toxicant in short-term studies and a carcinogen in rats and mice in... (Comparative Study)
Comparative Study
Glycidol (2,3-epoxy-1-propanol), an industrial chemical, has been shown to be a reproductive toxicant in short-term studies and a carcinogen in rats and mice in oncogenicity studies. The reproductive toxicity of glycidol was believed to result from its conversion to alpha-chlorohydrin by the action of HCl in the stomach. The comparative disposition of glycidol was investigated in rats following oral (po) or intravenous (iv) administration at doses of 37.5 and 75 mg/kg. These were the doses used in the National Toxicology Program (NTP) oncogenicity study with glycidol. Approximately 87-92% of the dose was absorbed from the gastrointestinal tract of the rat. [14C]Glycidol equivalents were eliminated in urine (40-48% of dose in 72 h), feces (5-12%), and exhaled as CO2 (26-32%). At both doses, 9-12% and 7-8% (estimated) of the dose remained in tissues at 24 and 72 h following dosing, respectively. In general, the concentrations of glycidol equivalents in tissues were proportional to the dose. The highest concentrations of radioactivity were observed in blood cells, thyroid, liver, kidney, and spleen, and the lowest in adipose tissue, skeletal muscle, and plasma. The pattern of distribution of radioactivity in tissues was similar for both the iv and po routes. The total recovery of radioactivity ranged from 87 to 91% of dose. Urinary radioactivity was resolved by high-performance liquid chromatography (HPLC) analysis into 15 metabolites. There were one major (14-21% of the dose) and four lesser metabolites (each representing 2-8%); the others were minor, each representing 1% or less of the dose. In general, the urinary metabolic profile was similar following either iv or po administration at the two doses studied. Previous studies by other investigators suggested that alpha-chlorohydrin, which was presumably formed from glycidol by the HCl in the stomach, was metabolized and excreted in urine as beta-chlorolactic acid. The results of the present study show that very little, if any, urinary radioactivity coeluted with authentic beta-chlorolactic acid following either iv or po administration. Therefore, it is concluded that the conversion of glycidol to alpha-chlorohydrin is quantitatively insignificant. However, it may be significant with regard to glycidol reproductive toxicity. Also, the NTP oncogenicity study with glycidol was carried out within the dose range in which its disposition characteristics were linear.
Topics: 1-Propanol; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epoxy Compounds; Injections, Intravenous; Intestinal Absorption; Male; Propanols; Rats; Rats, Inbred F344; Tissue Distribution
PubMed: 7853422
DOI: 10.1080/15287399509531955 -
Food and Chemical Toxicology : An... Jul 2020
Review
Topics: 1-Propanol; Databases, Chemical; Humans; Odorants; Perfume; Toxicity Tests
PubMed: 32461159
DOI: 10.1016/j.fct.2020.111425