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Indian Heart Journal Jul 1972
Topics: Adolescent; Adult; Atrial Fibrillation; Electric Countershock; Female; Humans; Male; Middle Aged; Mitral Valve Stenosis; Postoperative Complications; Propranolol; Recurrence
PubMed: 4658675
DOI: No ID Found -
Annals of Internal Medicine Jan 1974
Topics: Diabetes Complications; Female; Heroin Dependence; Humans; Middle Aged; Propranolol; Substance Withdrawal Syndrome
PubMed: 4810344
DOI: No ID Found -
Anesthesia and Analgesia 1975Propranolol therapy has been implicated as a cause of myocardial depression and increased morbidity and mortality in patients undergoing coronary artery surgery. The...
Propranolol therapy has been implicated as a cause of myocardial depression and increased morbidity and mortality in patients undergoing coronary artery surgery. The authors reviewed 169 consecutive patients undergoing cardiac surgery, of whom 143 had been taking propranolol, with regard to preoperative administration of propranolol and intraoperative or postoperative complications. Patients taking propranolol until 24 hours before surgery showed no increased incidence of hypotension or bradycardia before cardiopulmonary bypass. Hypotension after bypass was no more common in patients off propranolol 12 to 48 hours than in patients who either discontinued the drug over 48 hours before operation or had never taken the drug. Myocardial contractility as measured by systolic time intervals was normal 24 to 48 hours after stopping propranolol therapy. Five patients had preoperative myocardial infarctions within 48 hours of discontinuing the drug. The operative mortality rate was 4 percent in patients taking propranolol within 48 hours of surgery and 6 percent in all other patients. Seven risk factors, other than propranolol, were identified in those patients requiring inotropic support. The authors conclude that propranolol can be given safely within 24 to 48 hours of coronary artery surgery provided the patient is a satisfactory candidate for myocardial revascularization.
Topics: Angina Pectoris; Cardiac Surgical Procedures; Depression, Chemical; Humans; Myocardial Contraction; Myocardial Revascularization; Preoperative Care; Propranolol; Substance Withdrawal Syndrome
PubMed: 1237244
DOI: 10.1213/00000539-197509000-00003 -
Journal of Behavior Therapy and... Jun 2020Researchers have conceived of post-traumatic stress disorder (PTSD) as a disorder of memory, and proposed that blocking the impact of stress-related noradrenaline... (Clinical Trial)
Clinical Trial
BACKGROUND AND OBJECTIVES
Researchers have conceived of post-traumatic stress disorder (PTSD) as a disorder of memory, and proposed that blocking the impact of stress-related noradrenaline release in the aftermath of trauma may be a way of preventing the 'over-consolidation' of trauma-related memories. Experimental research in humans has been limited by typically focusing on declarative memory for emotional stories, and has mainly given propranolol before learning. In contrast, the clinical studies that we comprehensively review are hampered by practical challenges, such as reliably administering propranolol in a time window sufficiently close to the traumatic event. In this study, we aimed to assess the impact of both pre- and post-learning propranolol on emotional and declarative memory for an emotional scene, using the 'trauma film paradigm'.
METHODS
To control for drug and timing effects, participants received a pill (40 mg propranolol or placebo) both 60 min before and within 5 min after viewing a 12 min, emotionally arousing trauma film, and were assigned to one of the three conditions: propranolol-placebo (n = 25), placebo-propranolol (n = 25), or placebo-placebo (n = 25). We assessed participants' immediate emotional responses to the scene, as well as delayed impact (intrusions, Impact of Events Scale) and declarative memory.
RESULTS
Using Bayesian informative hypothesis testing, we found that pre-learning propranolol reduced the initial emotional impact of the 'trauma film'. However, we did not find strong evidence for an impact of pre- or post-learning propranolol on later consequences of having watched the emotional film (intrusions, Impact of Events, or tests of declarative memory). Exploratorily restricting analyses to women, we did find evidence suggesting that pre-encoding propranolol could reduce the rate of intrusions and self-reported negative impact of the emotional scene one week later.
LIMITATIONS
Floor effects in the delayed impact of the emotional scene could preclude observing differences as a function of propranolol, and propranolol dosage may need to be increased.
CONCLUSIONS
An impact of propranolol on encoding could raise difficulties in interpretation when only pre-encoding propranolol is used to make inferences about consolidation. We discuss the challenges of elucidating the mechanistic underpinnings of propranolol's reported effects on memory.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Bayes Theorem; Emotions; Female; Humans; Learning; Male; Memory; Mental Recall; Motion Pictures; Propranolol; Psychological Trauma; Young Adult
PubMed: 31122650
DOI: 10.1016/j.jbtep.2019.101480 -
Clinical Pharmacology and Therapeutics Jun 1977The intrinsic sinoatrial (SA) rate at rest and during exercise was measured in 5 normal male subjects after prolonged oral and acute intravenous administration of...
The intrinsic sinoatrial (SA) rate at rest and during exercise was measured in 5 normal male subjects after prolonged oral and acute intravenous administration of propranolol and atropine. At rest, the intrinsic SA rate was similar after both oral and intravenous propranolol. At the higher levels of power output on a cycle ergometer, cardiac rate was slower after oral than after intravenous propranolol. When the intravenous study was repeated with the use of an additional dose of propranolol, cardiac rate was lower at comparable levels of power output, but not as low as that after oral propanolol. Differences in responses were interpreted as reflecting varying degrees of beta blockade, the most complete being that after prolonged oral propranolol administration of 320 mg daily. The intravenous dose of propranolol usually used to obtain the "pharmacologically isolated heart" at rest is too small to induce full beta blockade in exercise.
Topics: Administration, Oral; Adult; Heart Rate; Humans; Infusions, Parenteral; Male; Physical Exertion; Propranolol; Rest
PubMed: 862308
DOI: 10.1002/cpt1977216700 -
British Medical Journal Aug 1976
Topics: Humans; Hypertension; Propranolol
PubMed: 947429
DOI: 10.1136/bmj.2.6031.367-d -
Ugeskrift For Laeger Dec 1979
Review
Topics: Female; Hemodynamics; Humans; Hypertension; Infant, Newborn; Pregnancy; Pregnancy Complications; Pregnancy Complications, Cardiovascular; Propranolol; Sympathetic Nervous System
PubMed: 392864
DOI: No ID Found -
British Journal of Clinical Pharmacology May 19781 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and...
1 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/-)-propranolol administration and remained unchanged during (+)-propranolol administration. 3 Hepatic extraction ratio was 74 +/- 1% (+/-)-propranolol and 79 +/- 2% for (+)-propranolol. 4 Total propranolol clearances were determined during the steady-state achieved by a constant infusion. A highly significant positive relationship was observed (r = +0.86; P less than 0.01) between hepatic blood flow and (+)-propranolol clearance. The slope of the curve was 1.05 +/- 0.27. 5 The result implies that the total clearance of (+)-propranolol constitutes an accurate estimation of basal hepatic blood flow in subjects with normal liver function.
Topics: Adult; Female; Hemodynamics; Humans; Indocyanine Green; Liver Circulation; Male; Propranolol
PubMed: 656285
DOI: 10.1111/j.1365-2125.1978.tb01655.x -
Journal of Clinical Pharmacy and... Dec 2010Eurycoma longifolia (E. longifolia), a herb commonly consumed for its aphrodisiac properties, is widely used by Asian males. This may include hypertensive patients... (Randomized Controlled Trial)
Randomized Controlled Trial
WHAT IS KNOWN AND BACKGROUND
Eurycoma longifolia (E. longifolia), a herb commonly consumed for its aphrodisiac properties, is widely used by Asian males. This may include hypertensive patients receiving propranolol which may cause sexual dysfunction as one of its side-effects. There is no published study of the potential pharmacokinetic interaction between propranolol and the herb.
OBJECTIVE
To study propranolol's pharmacokinetics when E. longifolia is consumed, comparing volunteers given either propranolol or a placebo.
METHODS
This is a placebo-controlled randomized single-blinded crossover study of the effect of a water-based extract of E. longifolia on the pharmacokinetics of a single dose of proporanolol (Inderal(®)) in 14 healthy non-smoker young males. Eighty milligram of propranonol was orally administered with (i) placebo (Lactose) or (ii) 200 mg of water-based extract of E. longifolia (0·0272 ± 0·0026%eurycomanone) following an overnight fasting. Blood samples were collected at 0, 0·5, 1, 1·5, 2, 3, 4, 6, 8 and 10 h for propranolol's plasma concentration determinations using a validated high-performance liquid chromatography (HPLC) method.
RESULTS AND DISCUSSION
When propranolol was administered with E. longifolia, its bioavailability (AUC0-∞) decreased by 29% while C(max) was reduced by 42% and T(max) was significantly prolonged by almost 86%. The terminal elimination half-life, however, was not significantly affected.
CONCLUSION
The bioavailability of propranolol is significantly decreased when consumed together with E. longifolia. The interaction is due to a reduction in absorption, rather than an increase in propranolol's metabolism. Although the pharmacodynamics of propranolol was not affected in healthy volunteers, caution is still advisable with co-administration of the drug and the herb.
Topics: Adult; Aphrodisiacs; Area Under Curve; Biological Availability; Cross-Over Studies; Eurycoma; Half-Life; Herb-Drug Interactions; Humans; Male; Phytotherapy; Plant Extracts; Plant Roots; Propranolol; Quassins; Sexual Dysfunction, Physiological; Single-Blind Method; Water; Young Adult
PubMed: 21054461
DOI: 10.1111/j.1365-2710.2009.01147.x -
JAMA Sep 1978The relationship between long-term propranolol hydrochloride therapy and subsequent coronary bypass operation was prospectively investigated in 119 patients who were...
The relationship between long-term propranolol hydrochloride therapy and subsequent coronary bypass operation was prospectively investigated in 119 patients who were grouped three ways: propranolol therapy continued in full dosage to operation (group A), propranolol therapy discontinued or tapered 24 to 72 hours preoperatively (group B), and no preoperative propranolol therapy (control group). During preoperative hospitalization, one patient in each group A and the control group suffered an increase in anginal symptoms compared with 15 patients in group B, three of whom also had new ventricular arrhythmias. During anesthesia up to the period of cardiopulmonary bypass, 26% of group A patients showed signs of ischemia (eg, ST segment deviation or ventricular arrhythmias) as compared with 51% of the control group and 70% of group B. Hypotension and bradycardia were not more common in group A patients. No differences among groups were noted in case of emergence from bypass, need for cardiac stimulants, or mortality.
Topics: Anesthetics; Angina Pectoris; Coronary Artery Bypass; Drug Interactions; Female; Humans; Male; Preoperative Care; Propranolol; Prospective Studies; Risk; Time Factors
PubMed: 308109
DOI: No ID Found