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Headache Jul 1977
Review
Topics: Animals; Humans; In Vitro Techniques; Migraine Disorders; Prostaglandins E; Rats
PubMed: 330466
DOI: 10.1111/j.1526-4610.1977.hed1703113.x -
L'Encephale 1990The authors assess the results of several studies, fundamental or clinical with therapeutic tests, to demonstrate a possible role of prostaglandins--specially of a... (Clinical Trial)
Clinical Trial Review
The authors assess the results of several studies, fundamental or clinical with therapeutic tests, to demonstrate a possible role of prostaglandins--specially of a possible lack of PGE1--in the pathogeny of certain forms of schizophrenia. The heterogeneousness of the results leads one to think there's heterogeneousness of the illness. Meanwhile, in certain cases, the contribution of a direct precursor of PGE1 the GLA, has given possible noticeable clinical results, mainly with deficiency symptoms.
Topics: Humans; Prostaglandins E; Schizophrenia; Schizophrenic Psychology
PubMed: 2265601
DOI: No ID Found -
Pediatric Cardiology 1982
Topics: Administration, Oral; Alprostadil; Dinoprostone; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Hemodynamics; Humans; Infant; Infant, Newborn; Infusions, Parenteral; Oxygen; Prostaglandins E
PubMed: 6956847
DOI: 10.1007/BF02426977 -
Acta Obstetricia Et Gynecologica... 1983
Review
Topics: Alprostadil; Animals; Dinoprost; Dinoprostone; Female; Humans; Male; Muscle Contraction; Prostaglandins; Prostaglandins E; Prostaglandins F; Ureter; Urethra; Urinary Bladder; Urinary Tract Physiological Phenomena; Urination Disorders
PubMed: 6344544
DOI: 10.3109/00016348309155198 -
Fertility and Sterility Apr 1987
Topics: Abortion, Induced; Dinoprostone; Female; Humans; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Prostaglandins E; Suppositories
PubMed: 3471533
DOI: 10.1016/s0015-0282(16)59134-1 -
British Medical Journal Sep 1979
Topics: Drug Stability; Female; Humans; Labor, Induced; Pessaries; Pregnancy; Prostaglandins E; Vaginal Creams, Foams, and Jellies
PubMed: 519197
DOI: 10.1136/bmj.2.6193.793 -
Biochimica Et Biophysica Acta Nov 1988Human seminal fluid contains prostaglandin (PG) E1, PGE2, 19-hydroxy-PGE1 and 19-hydroxy-PGE2 in large and variable amounts. 19-Hydroxy-PGE1 and 19-hydroxy-PGE2 are...
Human seminal fluid contains prostaglandin (PG) E1, PGE2, 19-hydroxy-PGE1 and 19-hydroxy-PGE2 in large and variable amounts. 19-Hydroxy-PGE1 and 19-hydroxy-PGE2 are formed from PGE1 and PGE2 by prostaglandin 19-hydroxylase, a cytochrome P-450 enzyme, in seminal vesicles. The hypothesis that genetic polymorphism of this enzyme might contribute to the variable concentrations of PGE1, PGE2, 19-hydroxy-PGE1 and 19-hydroxy-PGE2 was examined by analysis of seminal fluid of 40 normal men. E prostaglandins were measured with 17-phenyl-PGE2 as an internal standard by high-performance liquid chromatography on beta-cyclodextrin silica. Using the ratios of substrate/product, i.e., R1 = PGE1/19-hydroxy-PGE1 and R2 = PGE2/19-hydroxy-PGE2, as indicators of prostaglandin 19-hydroxylase capacity, a bimodal distribution of R values was found: nine men (23%) were slow hydroxylators (R1 greater than 0.45 and R2 greater than 0.45), while the remaining men were rapid hydroxylators (both R1 and R2 less than 0.45). Semen of slow hydroxylators and semen of the five most rapid hydroxylators (both R1 and R2 less than 0.10) differed in absolute amounts of PGE1 and PGE2 but not in 19-hydroxy-PGE1 and 19-hydroxy-PGE2. 20-Hydroxy-PGE1 and 20-hydroxy-PGE2 are formed from PGE1 and PGE2 by cytochrome P-450 in the vesicular glands and the ampullae of deferent ducts of the ram. Seminal fluid of five rams was analyzed for PGE1, PGE2, 20-hydroxy-PGE1 and 20-hydroxy-PGE2, and a large variation in substrate/product ratios was found. Polymorphism of cytochrome P-450 might contribute to variations in seminal prostaglandins in man and in sheep.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Prostaglandins E; Semen; Sheep; Species Specificity
PubMed: 3196735
DOI: 10.1016/0005-2760(88)90294-9 -
Prostaglandins Oct 1983
Review
Topics: Alprostadil; Animals; Blood Platelets; Digestive System; Gastric Acid; Gastrointestinal Motility; Platelet Aggregation; Prostaglandins E; Vasodilation
PubMed: 6361908
DOI: 10.1016/0090-6980(83)90189-2 -
Molecules (Basel, Switzerland) Jun 2011Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced... (Review)
Review
Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl ε-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo.
Topics: Animals; Humans; Molecular Structure; Prostaglandins E
PubMed: 21705973
DOI: 10.3390/molecules16075333 -
Journal of the Oslo City Hospitals 1989Similar distributions of prostaglandins in urine and renal venous blood both during prostaglandin infusion and stimulated synthesis indicated a vascular origin for both... (Review)
Review
Similar distributions of prostaglandins in urine and renal venous blood both during prostaglandin infusion and stimulated synthesis indicated a vascular origin for both urinary and renal venous PGE2 and PGI2. Various stimulation procedures demonstrated that the renal vasculature releases PGE2 and PGI2 in a fixed proportion. Renal degradation of circulating prostaglandins was not influenced by ureteral occlusion and seems to be mainly confined to the blood vessels. The vascular capacity for both synthesis and degradation was much greater for PGE2 than for PGI2. Urinary PGE2 was shown to be of renal origin, but constituted a small and variable fraction of renally produced PGE2, making it a poor estimate of renal PGE2 synthesis. Urinary 6-keto-PGF1 alpha may originate from renal PGI2 production or from circulating 6-keto-PGF1 alpha which readily appears in the urine. Equimolar infusions of PGE2 and PGI2 demonstrated that PGI2 was a more potent stimulator of renin release than PGE2, but the difference seemed to be mainly due to differences in degradation and not to differences in intrinsic potency. Prostaglandins stimulated renin release only when the intrarenal mechanisms for renin release were activated and not at control blood pressure and free urine flow. beta-adrenoceptor agonists stimulated renin release independently of activation of the macula densa, but required activation of the hemodynamic mechanism. Ethacrynic acid activated both the hemodynamic and the macula densa mechanism, but had no direct stimulatory effect on renin release. PGE2 and PGI2 were released during autoregulatory vasodilation, but neither PGE2 nor PGI2 participated in the autoregulatory mechanism. Autoregulatory and prostaglandin mediated vasodilation seems to be independent. Descending autoregulatory vasodilation was demonstrated during successive reductions in RAP, but a more simultaneous dilation of all preglomerular vessels was indicated during successive elevations of ureteral pressure. This difference may be due to participation of TGF together with the myogenic mechanism in autoregulation of RBF. Participation of TGF may also explain why prostaglandin and renin release dissociate during successive reductions in RAP, but increase in parallel during successive elevations of ureteral pressure. It also explains why maximal renin release induced both by the hemodynamic and the macula densa mechanism coincides with the breaking point of the RBF autoregulatory curve, and why loop diuretics induce complete autoregulatory vasodilation at control blood pressure.
Topics: Animals; Dogs; Hemodynamics; Prostaglandins E; Renal Circulation; Renin
PubMed: 2693665
DOI: No ID Found