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The American Journal of Surgical... Aug 1988The prostate gland contains three major glandular regions--the peripheral zone, the central zone, and the transition zone--which differ histologically and biologically....
The prostate gland contains three major glandular regions--the peripheral zone, the central zone, and the transition zone--which differ histologically and biologically. The central zone is relatively resistant to carcinoma and other disease; the transition zone is the main site of origin of prostate hyperplasia. There are also several important nonglandular regions concentrated in the anteromedial portion of the gland. Each glandular zone has specific architectural and stromal features. In all zones, both ducts and acini are lined by secretory epithelium. In each zone, there is a layer of basal cells beneath the secretory lining, as well as interspersed endocrine-paracrine cells. Frequent deviations from normal histology include post-inflammatory atrophy, basal cell hyperplasia, benign nodular hyperplasia, atypical adenomatous hyperplasia, and duct-acinar dysplasia. These lesions may at times be confused with carcinoma, especially in biopsy material.
Topics: Biopsy; Humans; Male; Prostate; Prostatic Diseases; Prostatic Hyperplasia; Prostatitis
PubMed: 2456702
DOI: 10.1097/00000478-198808000-00003 -
JAMA Oct 1961
Topics: Disease; Humans; Male; Prostate; Prostatic Diseases; Prostatism; Uremia; Urinary Bladder Diseases; Urinary Bladder Neck Obstruction
PubMed: 13887610
DOI: 10.1001/jama.1961.03040420036008 -
The Journal of Urology May 2008
Topics: Animals; Biomarkers; Chronic Disease; Diagnosis, Differential; Diagnostic Imaging; Humans; Male; Pelvic Pain; Prostate; Prostatitis
PubMed: 18405757
DOI: 10.1016/j.juro.2008.03.001 -
Transactions. American Urological... 1952
Topics: Humans; Male; Orthopedic Procedures; Prostate; Prostatism; Urologic Surgical Procedures
PubMed: 13064714
DOI: No ID Found -
Bulletin of Experimental Biology and... Jan 2021We performed a complex morphological study of biopsy samples of prostate gland from 30 men (mean age 46±11 years) with chronic abacterial prostatitis who were exposed...
We performed a complex morphological study of biopsy samples of prostate gland from 30 men (mean age 46±11 years) with chronic abacterial prostatitis who were exposed unfavorable anthropogenic factors. The ultrastructural heterogeneity of smooth muscle cells was shown, among which cells with destructive changes in organelles predominated, solitary cells with signs of secretory function were revealed. Most endothelial cells in microvessels were characterized by low pinocytotic activity, destruction of organelles; focal hyperplastic ultrastructural changes were noted in some endotheliocytes. Along with fibroblasts, the stroma contained single mast cells; no inflammatory infiltration was revealed. The results of the study attested to complex mechanisms of remodeling of the prostate gland stroma in chronic abacterial prostatitis involving microvessels, smooth muscle cells, and probably mast cells, which determines the development of degenerative, destructive, and fibrotic processes.
Topics: Adult; Chronic Disease; Endothelial Cells; Humans; Male; Middle Aged; Myocytes, Smooth Muscle; Prostate; Prostatitis
PubMed: 33452988
DOI: 10.1007/s10517-021-05073-y -
Nihon Hinyokika Gakkai Zasshi. the... Apr 1993
Review
Topics: Biopsy; Emphysema; Granuloma; Humans; Male; Prostate; Prostatitis; Ultrasonography
PubMed: 8492505
DOI: 10.5980/jpnjurol1989.84.625 -
The Journal of Urology Jan 1967
Topics: Body Fluids; Humans; Male; Prostate; Prostatitis
PubMed: 6016200
DOI: 10.1016/S0022-5347(17)63000-3 -
European Urology May 2014
Reply from authors re: Charalampos Mamoulakis. A plea for higher-quality data for GreenLight laser technology in the context of surgical benign prostatic obstruction trials: the GOLIATH study-fact or fiction in the era of evidence-based urology? Eur Urol 2014;65:943-5.
Topics: Humans; Laser Therapy; Male; Prostate; Prostatectomy; Prostatic Hyperplasia; Prostatism
PubMed: 24388437
DOI: 10.1016/j.eururo.2013.12.013 -
The Journal of Urology Dec 2004Since few men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have culturable bacteria by traditional approaches, we used sensitive molecular methods to...
PURPOSE
Since few men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have culturable bacteria by traditional approaches, we used sensitive molecular methods to determine presence of fastidious microorganisms.
MATERIALS AND METHODS
We evaluated 135 men with CP/CPPS by standardized clinical evaluation, and by lower tract localization cultures and chamber counts of expressed prostatic secretions of leukocytes. We excluded from study patients with bacteriuria, bacterial prostatitis, urethritis or positive urethral cultures. Prostate biopsy was obtained using a double-needle technique to limit contamination. We chose molecular approaches because previous studies had used culture antigen detection in urine, urethral swabs and expressed prostatic secretions. However, interpretation of such studies is complicated because urogenital samples often acquire bacteria while passing through the urethra. We used specific and broad-spectrum polymerase chain reaction (PCR) assays.
RESULTS
Only 10 (8%) of the 135 subjects had positive specific PCR assays, including Mycoplasmia genitalium, Chlamydia trachomatis and Trichomonas vaginalis. Our findings suggested that C. trachomatis, T. vaginalis and M. genitalium may be identified in some patients with CP/CPPS, even among men with no evidence of urethritis and with negative urethral cultures and other assays. The broad-spectrum PCR assays provided the most provocative findings. DNA encoding tetracycline resistance was identified in 25% of subjects, and 77% of subjects had evidence of 16S rDNAs. The white blood cell concentration in the prostatic secretions correlated with identification of 16S rDNAs in prostate tissue (p <0.01).
CONCLUSIONS
Delineating the precise role of these organisms in the etiology of CP/CPPS may help define better diagnostic and treatment algorithms.
Topics: Chronic Disease; Genitalia, Male; Humans; Male; Mycoplasma genitalium; Pelvic Pain; Polymerase Chain Reaction; Prostate; Prostatitis; Syndrome; Urethritis; Virginia; Washington
PubMed: 15538207
DOI: 10.1097/01.ju.0000144291.05839.a0 -
Seminars in Roentgenology Oct 1999
Review
Topics: Acute Disease; Diagnosis, Differential; Endosonography; Humans; Male; Prostate; Prostatitis
PubMed: 10553607
DOI: 10.1016/s0037-198x(99)80009-1