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Seminars in Cutaneous Medicine and... Dec 1996Since the first description by Saltzstein in 1959, the denomination of drug-induced pseudolymphoma was used to describe two cutaneous adverse drug reactions with a... (Review)
Review
Since the first description by Saltzstein in 1959, the denomination of drug-induced pseudolymphoma was used to describe two cutaneous adverse drug reactions with a histological picture mimicking malignant lymphoma. On the basis of clinical presentation, this term includes two different patterns: (1) hypersensitivity syndrome which begins acutely in the first 2 months after the initiation of the drug and associates fever, a severe skin disease with characteristic infiltrated papules and facial edema or an exfoliative dermatitis, lymphadenopathy, hematologic abnormalities (hypereosinophilia, atypical lymphocytes) and organ involvement such as hepatitis, carditis, interstitial nephritis, or interstitial pneumonitis. The cutaneous histological pattern shows a lymphocytic infiltrate, sometimes mimicking a cutaneous lymphoma, and the mortality rate is about 10%. When organ involvement exists, corticosteroids are often prescribed with dramatic improvement. Relapses may occur. (2) drug-induced pseudolymphoma which has a more insidious beginning with nodules and infiltrated plaques appearing several weeks after the beginning of the drug without constitutional symptoms. A pseudolymphoma pattern is seen on cutaneous histological slides. Complete improvement is usual after drug withdrawal, but a delayed lymphoma is possible. To decrease the ambiguity of the denomination of hypersensitivity syndrome, we propose the term of DRESS (Drug Rash with Eosinophilia and Systemic Symptoms).
Topics: Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity; Eosinophilia; Humans; Hydantoins; Hypersensitivity, Delayed; Prognosis; Pseudolymphoma; Skin Diseases; Sulfonamides; Syndrome
PubMed: 9069593
DOI: 10.1016/s1085-5629(96)80038-1 -
Journal of Neuro-oncology Apr 2000Intracranial pseudolymphoma is a rare tumor of the central nervous system. A 35-year-old woman presented with a frontal subcutaneous tumor. Magnetic resonance imaging...
Intracranial pseudolymphoma is a rare tumor of the central nervous system. A 35-year-old woman presented with a frontal subcutaneous tumor. Magnetic resonance imaging revealed a left frontal meningeal tumor involving subcutaneous tissue without bone involvement. The mass was completely removed and the histological aspect of all tumor sections was that of a lymphoid hyperplasia with polyclonal proliferation. These findings were characteristic of pseudolymphoma defined as a hyperplasia of follicular and diffuse lymphoid type with assessment of its polyclonality by immunophenotyping on frozen sections, completed by molecular biology techniques.
Topics: Adult; Brain; Brain Neoplasms; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Pseudolymphoma
PubMed: 10982160
DOI: 10.1023/a:1006414717891 -
Deutsches Arzteblatt International May 2022
Topics: Anti-Bacterial Agents; Humans; Lyme Disease; Pseudolymphoma
PubMed: 36017988
DOI: 10.3238/arztebl.m2022.0015 -
JAMA Dermatology Jun 2022
Topics: Antibodies, Monoclonal, Humanized; Humans; Pseudolymphoma; Skin Diseases; Skin Neoplasms
PubMed: 35416914
DOI: 10.1001/jamadermatol.2022.0613 -
Histology and Histopathology Oct 2012The term pseudolymphoma refers to a heterogeneous group of benign reactive T-cell or B-cell lymphoproliferative processes of diverse causes that simulate lymphoma... (Review)
Review
The term pseudolymphoma refers to a heterogeneous group of benign reactive T-cell or B-cell lymphoproliferative processes of diverse causes that simulate lymphoma clinically and histologically but usually undergo spontaneous remission. Its pathogenesis is still unclear. The prognosis is good although some evidence suggests that pseudolymphoma may progress to lymphoma. Pseudolymphoma of the urinary tract is extremely rare. We herein report a case of pseudolymphoma of the renal sinus in a 70-year-old man, associated with a high grade urothelial carcinoma of the bladder and to a prostatic adenocarcinoma (Gleason score 6). A brief review of the literature is included. The kidney showed a well-defined, whitish soft mass which involved the renal sinus. Microscopically, the lesion of the renal sinus consisted of a proliferation of small to medium size lymphocytes (CD20 positive and Bcl-2 negative) sometimes arranged in hyperplastic follicular structures. The diagnosis was confirmed by molecular studies which showed an oligopolyclonal IgH rearrangement. To the best of our knowledge, this is the second case of pseudolymphoma with a complete molecular characterization ever described in the renal sinus and the first one associated with multiple urogenital carcinomas.
Topics: Adenocarcinoma; Aged; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Humans; Kidney Diseases; Male; Neoplasms, Multiple Primary; Prostatic Neoplasms; Pseudolymphoma; Urinary Bladder Neoplasms
PubMed: 22936451
DOI: 10.14670/HH-27.1327 -
Der Hautarzt; Zeitschrift Fur... Feb 2022The term cutaneous pseudolymphoma (C-PSL) is defined in the literature as a benign, reactive lymphoproliferation that clinically and/or histopathologically imitates...
The term cutaneous pseudolymphoma (C-PSL) is defined in the literature as a benign, reactive lymphoproliferation that clinically and/or histopathologically imitates cutaneous lymphoma. The exact etiopathogenesis has not been fully elucidated to date. A distinction is made between primary, idiopathic PSL without an identifiable cause and secondary PSL with a known stimulus. We report the occurrence of pseudolymphoma after treatment with medicinal leeches (hirudotherapy). To the best of our knowledge, a total of only nine cases of cutaneous PSL after hirudotherapy have been reported in the literature to date.
Topics: Humans; Lymphoma, Non-Hodgkin; Pseudolymphoma; Skin Neoplasms
PubMed: 33884433
DOI: 10.1007/s00105-021-04812-6 -
Scandinavian Journal of Rheumatology 2001Sjögren's syndrome (SS) is known to be associated with pseudolymphoma in several organs. We describe a patient with SS complicated by a hepatic pseudolymphoma. Although... (Review)
Review
Sjögren's syndrome (SS) is known to be associated with pseudolymphoma in several organs. We describe a patient with SS complicated by a hepatic pseudolymphoma. Although the development of a hepatic pseudolymphoma is extremely rare, this disorder should be taken into consideration in the differential diagnosis of space occupying lesions related to autoimmune diseases such as SS.
Topics: Female; Humans; Liver; Liver Diseases; Magnetic Resonance Imaging; Middle Aged; Pseudolymphoma; Sjogren's Syndrome
PubMed: 11324789
DOI: 10.1080/03009740151095466 -
Acta Dermatovenerologica Croatica : ADC Jun 2019Pseudolymphoma is a benign, reversible, inflammatory, reactive, and polyclonal lymphocyte proliferation, which regresses spontaneously or heals after elimination of the...
Pseudolymphoma is a benign, reversible, inflammatory, reactive, and polyclonal lymphocyte proliferation, which regresses spontaneously or heals after elimination of the causal factor. A female patient, aged 33, presented with a painful, erythematosus, radiant tumor formation on the skin in the temporal region. The patient had enlarged lymph nodes on the right side of the neck before the appearance of that tumor formation. The dermatoscopic finding was nonspecific. After the tumor biopsy was performed, the diagnosis of reactive lymphatic proliferation - pseudolymphoma or cutaneous lymphoma of B-cell immunophenotype - was established histologically. After we completely excised the skin change, the immunohistochemical finding indicated fluoride skin lymphocyte hyperplasia of B- and T-lymphocytes. The results of other findings were normal (serologic test for Borrelia burgdoferi, ultrasound of the cervical and supraclavicular lymph nodes, as well as ultrasound of the abdomen and axillary and inguinal regions). However, the etiology of the disease remains unknown. This case report confirms that the correlation between clinical presentation, dermatoscopic examination, histologic and immunohistochemical analysis, and the therapy response is crucial for diagnosis of pseudolymphoma and patient outcome.
Topics: Adult; Biopsy; Dermoscopy; Diagnosis, Differential; Face; Female; Humans; Pseudolymphoma; Skin Diseases
PubMed: 31351507
DOI: No ID Found -
BMJ Case Reports Oct 2018
Topics: Analgesics; Biopsy; Diagnosis, Differential; Female; Gabapentin; Humans; Middle Aged; Pseudolymphoma; Skin Diseases
PubMed: 30344158
DOI: 10.1136/bcr-2018-227245 -
RoFo : Fortschritte Auf Dem Gebiete Der... May 2023
Topics: Humans; Pseudolymphoma; Diagnosis, Differential; Hypothalamus, Posterior; Neoplasms
PubMed: 36791770
DOI: 10.1055/a-1997-9041