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Revue Roumaine de Physiologie... 1992The recent findings on the close relation between the nervous and immune systems have led to the developing of a new interdisciplinary field: psychoneuroimmunology. This... (Review)
Review
The recent findings on the close relation between the nervous and immune systems have led to the developing of a new interdisciplinary field: psychoneuroimmunology. This review outlines the topic of the research, the limits and the future trends of psychoneuroimmunology, emphasizing the reciprocal relationship between biological and psychological processes.
Topics: Behavior; Humans; Immune System; Mental Disorders; Nervous System Physiological Phenomena; Personality; Psychoneuroimmunology; Psychotropic Drugs; Stress, Psychological
PubMed: 1472551
DOI: No ID Found -
Rhode Island Medical Journal Nov 1990Complex interactions among the nervous, endocrine, and immune systems have been documented and these are currently being studied at the cellular and molecular levels... (Review)
Review
Complex interactions among the nervous, endocrine, and immune systems have been documented and these are currently being studied at the cellular and molecular levels with ever more powerful tools. They have an important impact on diseases affecting the three systems, in particular on autoimmune and infectious diseases of the nervous system. In time neuroimmunological diseases and psychoneuroimmunological relationships may become as "respectable" as the more familiar neuroendocrine diseases and relationships.
Topics: Humans; Psychoneuroimmunology
PubMed: 2263853
DOI: No ID Found -
Psychoneuroendocrinology Jun 2018Despite the high prevalence of neural and immune disorders, their etiology and molecular mechanisms remain poorly understood. As the zebrafish (Danio rerio) is... (Review)
Review
Despite the high prevalence of neural and immune disorders, their etiology and molecular mechanisms remain poorly understood. As the zebrafish (Danio rerio) is increasingly utilized as a powerful model organism in biomedical research, mounting evidence suggests these fish as a useful tool to study neural and immune mechanisms and their interplay. Here, we discuss zebrafish neuro-immune mechanisms and their pharmacological and genetic modulation, the effect of stress on cytokines, as well as relevant models of microbiota-brain interplay. As many human brain diseases are based on complex interplay between the neural and the immune system, here we discuss zebrafish models, as well as recent successes and challenges, in this rapidly expanding field. We particularly emphasize the growing utility of zebrafish models in translational immunopsychiatry research, as they improve our understanding of pathogenetic neuro-immune interactions, thereby fostering future discovery of potential therapeutic agents.
Topics: Animals; Brain; Brain Diseases; Disease Models, Animal; Humans; Mental Disorders; Psychoneuroimmunology; Translational Research, Biomedical; Zebrafish
PubMed: 29609110
DOI: 10.1016/j.psyneuen.2018.03.014 -
International Dental Journal Dec 2022Psychoneuroimmunology (PNI) is an area of interdisciplinary research exploring the complex interactions within the immuno-neuro-endocrine system in response to... (Review)
Review
Psychoneuroimmunology (PNI) is an area of interdisciplinary research exploring the complex interactions within the immuno-neuro-endocrine system in response to psychosocial influences. Such influences can trigger neurological changes, leading to immunological effects related to the emergence and course of various diseases. This concise clinical review explores the role of PNI in oral medicine in three exemplary models of oral disease: periodontitis, herpes labialis, and oral lichen planus. Previous literature has shown that psychosocial stress is related to exacerbations in these three oral diseases and to poorer overall oral health. The presumed biological mechanisms affect the activity of stress axes, i.e. the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), and subsequent immune system dysregulation. Although these PNI mechanisms remain poorly understood, several stress reduction interventions in clinical oral medicine have already yielded promising results. In future work, the elucidation of pathways within PNI networks will require carefully designed studies with sensitive methodology, e.g. the integrative single-case design. A biopsychosocial approach has the potential to move disease models in oral medicine from simple connections rooted in empirical dualism and reductionism to the establishment of network-based models. Further research on these complex connections should lead to novel clinical approaches and preventive strategies in oral medicine.
Topics: Humans; Psychoneuroimmunology; Stress, Psychological; Oral Medicine
PubMed: 36184323
DOI: 10.1016/j.identj.2022.07.002 -
Brain, Behavior, and Immunity Aug 2020The Psychoneuroimmunology Research Society (PNIRS) created an official Chinese regional affiliate in 2012, designated PNIRS. Now, just eight years later, the program has... (Review)
Review
The Psychoneuroimmunology Research Society (PNIRS) created an official Chinese regional affiliate in 2012, designated PNIRS. Now, just eight years later, the program has been so successful in advancing the science of psychoneuroimmunology that it has expanded to the whole of Asia-Oceania. In 2017, PNIRS became PNIRS. Between 2012 and 2019, this outreach affiliate of PNIRS organized seven symposia at major scientific meetings in China as well as nine others in Taiwan, Japan, South Korea, Australia and New Zealand. This paper summarizes the remarkable growth of PNIRS. Here, regional experts who have been instrumental in organizing these PNIRS symposia briefly review and share their views about the past, present and future state of psychoneuroimmunology research in China, Taiwan, Australia and Japan. The newest initiative of PNIRS is connecting Asia-Pacific laboratories with those in Western countries through a simple web-based registration system. These efforts not only contribute to the efforts of PNIRS to serve a truly global scientific society but also to answer the imperative call of increasing diversity in our science.
Topics: Asia; Australia; China; Japan; Psychoneuroimmunology; Republic of Korea; Taiwan
PubMed: 32304882
DOI: 10.1016/j.bbi.2020.04.026 -
Seminars in Gastrointestinal Disease Jan 1999Psychoneuroimmunology is the scientific field that investigates linkages between the brain, behavior, and the immune system and the implications of these linkages for... (Review)
Review
Psychoneuroimmunology is the scientific field that investigates linkages between the brain, behavior, and the immune system and the implications of these linkages for physical health and disease. Recent evidence suggests that both naturalistic and laboratory stressors can alter enumerative and functional aspects of the human immune system. Chronic stress may increase vulnerability to infectious disease; however, the role of stress in the course of inflammatory bowel disease remains unclear. Because there are large individual differences in psychological response to stress, it is important to consider the role of cognitive and affective responses to stress. Depression has been associated with functional immune decrements and immune overactivation. Cognitive states such as perceived control, views of the self, and views of the future have been associated with immune parameters and health in some studies. Very few controlled clinical trials have been conducted to determine if psychosocial interventions can impact the immune system and the progression of medical conditions. There is suggestive evidence for the health benefits of relaxation training, cognitive-behavioral stress management, and support groups; but, there is little research on many other psychosocial interventions in widespread use for medical conditions. An evidence-based discussion of this research literature with interested patients may help them make informed decisions regarding adjunctive treatments.
Topics: Affect; Cognition; Depression; Humans; Immune System; Neoplasms; Psychoneuroimmunology; Stress, Psychological
PubMed: 10065769
DOI: No ID Found -
Brain, Behavior, and Immunity Mar 2021
Review
Topics: Immune System; Psychoneuroimmunology; Stress, Psychological
PubMed: 33383146
DOI: 10.1016/j.bbi.2020.12.023 -
Brain, Behavior, and Immunity Jul 2018
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Brain, Behavior, and Immunity Aug 2020The future of psychoneuroimmunology requires breakthrough technology discoveries. These next generation technologies need to address the unique challenges that are... (Review)
Review
The future of psychoneuroimmunology requires breakthrough technology discoveries. These next generation technologies need to address the unique challenges that are raised by imaging and measuring the activity of the neuroimmune interface in health and disease. The complexity of this challenge is centred around the multidimensionality of the neuroimmune system. These include novel challenges of capturing potent and rare biological signals over long times and vast anatomical distances. Here is a summary of the outcomes of the investments made by the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics which was presented as part of the PNIRSAsia-Pacific symposium at the 2019 International Brain Research Organization.
Topics: Australia; Brain; Immune System; Psychoneuroimmunology
PubMed: 32289367
DOI: 10.1016/j.bbi.2020.04.029 -
Behavioral and Cognitive Neuroscience... Jun 2004Psychoneuroimmunology (PNI) emerged in the neurosciences in the late 1970s to early 1980s and has extended to influence the fields of psychology, psychiatry,... (Review)
Review
Psychoneuroimmunology (PNI) emerged in the neurosciences in the late 1970s to early 1980s and has extended to influence the fields of psychology, psychiatry, endocrinology, physiology, and the biomedical research community. This review documents the journey of PNI from the early 1980s to the present. Today, we recognize that the highly complex immune system interacts with an equally complex nervous system in a bidirectional manner. Evolutionarily old signals continue to play a role in these communications, as do mechanisms for protection of the host. The disparity between physical and psychological stressors is only an illusion. Host defense mechanisms respond in adaptive and meaningful ways to both. The present review will describe a new way of thinking about evolutionarily old molecules, heat shock proteins, adding to a body of evidence suggesting that activation of the acute stress response is a double-edged sword that can both benefit and derail optimal immunity.
Topics: Forecasting; Heat-Shock Proteins; History, 20th Century; History, 21st Century; Humans; Nitric Oxide; Psychoneuroimmunology; Sick Role; Stress, Physiological
PubMed: 15537988
DOI: 10.1177/1534582304269027