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Ophthalmic Genetics Dec 2016Epidemiological reports strongly indicate that pterygium is an ophthalmoheliosis: a sun-related eye disease. Familial occurrence of pterygium is rare but supports the...
Epidemiological reports strongly indicate that pterygium is an ophthalmoheliosis: a sun-related eye disease. Familial occurrence of pterygium is rare but supports the concept that heredity may predispose the conjunctiva to react abnormally to atmospheric-environmental stimuli. We describe a two generation Caucasian family of five members from the United Kingdom, four of whom developed pterygia in early adulthood with autosomal dominant inheritance. The present report confirms the significance of heredity in the pathogenesis of pterygium. Understanding the genetic basis of pterygium pathogenesis is clinically relevant, particularly in the management of patients who develop recurrent and aggressive pterygia at younger ages.
Topics: Adult; Aged; Female; Heredity; Humans; Male; Middle Aged; Pedigree; Pterygium; United Kingdom; Visual Acuity; White People
PubMed: 26933759
DOI: 10.3109/13816810.2015.1111911 -
American Journal of Medical Genetics.... Nov 2014We describe an adolescent Peruvian male with marked, aggressive ingrowth of conjunctiva (pterygium-like) over the cornea associated with keloid formation on his distal...
We describe an adolescent Peruvian male with marked, aggressive ingrowth of conjunctiva (pterygium-like) over the cornea associated with keloid formation on his distal limbs. He has in addition camptodactyly of all fingers and to some extent of his toes, and unusual skin pigmentations. He resembles an earlier described family from Norway in which a mother and two children showed a similar combination of signs. We present the follow-up of the Norwegian family. The entity resembles the Penttinen syndrome but can be differentiated due to the early aging in the latter, which is lacking in the presently reported entity. We suggest naming this entity ocular pterygium-digital keloid dysplasia. The condition follows likely an autosomal dominant pattern of inheritance.
Topics: Child; Child, Preschool; Facies; Fingers; Humans; Keloid; Male; Phenotype; Pterygium; Skin Pigmentation; Toes
PubMed: 25124224
DOI: 10.1002/ajmg.a.36713 -
The New Zealand Medical Journal 1953
Topics: Humans; Pterygium
PubMed: 13133145
DOI: No ID Found -
Genetic Counseling (Geneva, Switzerland) 1990The Lethal Multiple Pterygium Syndrome (LMPS) is characterised by lethality, multiple pterygia and frequently hydrops and/or hygroma colli. In this paper, we review 36... (Review)
Review
The Lethal Multiple Pterygium Syndrome (LMPS) is characterised by lethality, multiple pterygia and frequently hydrops and/or hygroma colli. In this paper, we review 36 published cases, discuss the clinical features, pathogenesis, differential diagnosis and mode(s) of inheritance. Most cases were diagnosed in the second trimester of pregnancy by hydrops/hygroma colli at ultrasonography and/or stillbirth. Pterygia were present in two or more body areas overlying predominantly the large joints; joint contractures always accompany the pterygia. Facial features are: hypertelorism, antimongoloïd slanting of the palpebral fissures, flattened nasal bridge with hyproplastic nasal alae, micrognathia and cleft palate. Lung hypoplasia is the rule. Except for hypoplastic bones there were no consistent radiological findings. Cerebral abnormalities were occasionally found; muscular atrophy was mentioned in a number of cases. Chromosome abnormalities were never reported. Based on clinical presentation we propose an "early type" of LMPS and a "late type" of LMPS. Besides, we consider the cases described by Herva as a separate "Finnish type" LMPS. We found an excess of male cases, especially in young fetuses. LMPS is known as an autosomal recessive inherited trait. X-linked recessive inheritance however cannot be excluded in an isolated male case or in a sibship with males only. The Finnish type of LMPS appears to be an autosomal recessive trait.
Topics: Contracture; Diagnosis, Differential; Face; Female; Genes, Lethal; Humans; Hydrops Fetalis; Karyotyping; Lung; Pregnancy; Pregnancy Complications; Pterygium; Syndrome
PubMed: 2222917
DOI: No ID Found -
European Journal of Ophthalmology Jul 2023To measure the central corneal thickness (CCT) using anterior segment optical coherence tomography (AS-OCT) in older adults with and without pterygium from the Brazilian...
PURPOSE
To measure the central corneal thickness (CCT) using anterior segment optical coherence tomography (AS-OCT) in older adults with and without pterygium from the Brazilian Amazon Region Eye Survey (BARES).
METHODS
BARES is a population-based epidemiological cross-sectional study conducted in Parintins city. Participants were residents ≥45 years of age identified through a door-to-door interview. Eligible participants were invited for a comprehensive eye exam. Pterygium occurrence and severity were assessed by ophthalmologists through slit-lamp examination considering its location (nasal or/and temporal) and severity (lesion with extension <3 mm, ≥3 mm not reaching the pupillary margin or ≥3 mm reaching the pupillary margin). CCTs were obtained and measurements from the more severely affected eye were included. Images were analyzed offline by masked observers.
RESULTS
A total of 671 subjects, 533 (79.4%) with pterygium in at least one eye and 138 (20.6%) without pterygium in either eye, were examined. The mean CCT evaluated by multiple linear regression and adjusted for demographic variables and pterygium severity was 521 ± 34 μm (median = 521; range = 304-665). Decreased CCT was significantly associated with age and pterygium severity. Individuals aged 65-74 years had CCT 7 μm thinner than those aged 45-54 years ( = 0.044), individuals aged 75 years and older had CCT 15 μm thinner than those aged 45-54 years ( = 0.001), and eyes with severe pterygium had CCT 33 μm thinner than eyes without pterygium ( < 0.001).
CONCLUSIONS
The CCT analysis in this population-based sample shows that a thinner cornea is associated with pterygium severity and older age.
Topics: Humans; Aged; Middle Aged; Pterygium; Tomography, Optical Coherence; Cross-Sectional Studies; Cornea; Reproducibility of Results; Corneal Pachymetry
PubMed: 36726300
DOI: 10.1177/11206721231154433 -
Ophthalmic Plastic and Reconstructive... Dec 1994Although complications associated with the use of beta radiation after pterygium surgery can occur, the author has found the use of beta radiation to be beneficial in... (Review)
Review
Although complications associated with the use of beta radiation after pterygium surgery can occur, the author has found the use of beta radiation to be beneficial in preventing recurrences when used with pterygium surgery. An effective surgical regime of pterygium surgery is presented. A procedure made up of steps that tend to prevent revascularization of the operative site after pterygium surgery will decrease the recurrence rate. The use of strontium 90 and the mechanism of action of beta ray therapy in treatment of the pterygium is discussed. Few complications have occurred in > 200 surgically treated cases of pterygium with postoperative beta radiation administered with a strontium 90 applicator. No cases of radiation cataract have been observed.
Topics: Beta Particles; Combined Modality Therapy; Conjunctiva; Humans; Postoperative Care; Pterygium; Recurrence; Strontium Radioisotopes
PubMed: 7865444
DOI: 10.1097/00002341-199412000-00004 -
Journal Francais D'ophtalmologie Jun 2024
Review
Topics: Humans; Conjunctival Neoplasms; Pterygium; Carcinoma in Situ; Male; Female; Middle Aged
PubMed: 38490939
DOI: 10.1016/j.jfo.2024.104149 -
Cornea Jul 2014The aim of this study was to investigate the relationship between pterygium and a decrease in the corneal endothelial cell density (ECD) in patients with unilateral...
PURPOSE
The aim of this study was to investigate the relationship between pterygium and a decrease in the corneal endothelial cell density (ECD) in patients with unilateral primary pterygium.
METHODS
In this retrospective cross-sectional study, 90 consecutive patients with unilateral primary pterygium were enrolled from January 2010 to June 2012. Corneal ECD was measured in both eyes, and the fellow eyes were considered as controls. The relationship between the percentage of pterygium to cornea and a decrease in the ECD was analyzed. An increase in astigmatism in eyes with pterygium was evaluated for association with decreased ECD using the Pearson correlation test.
RESULTS
The percentage of pterygium to cornea ranged from 3.5% to 65.2%, with a median of 12.35%. The difference in the corneal ECD between eyes with pterygium and control eyes ranged from +9.6% to -37.7%, with a median of -9.75%. The results of the Pearson correlation statistical test showed a strong logarithmic correlation between a decrease in the corneal ECD and the percentage of pterygium to cornea (R = 0.688, P < 0.001). An increase in astigmatism was correlated with a decrease in the ECD in eyes with pterygium.
CONCLUSIONS
Pterygium is related to a decrease in corneal ECD. Surgical intervention should be considered in patients with extensive pterygium involvement in the cornea or a significant increase in astigmatism.
Topics: Adult; Aged; Aged, 80 and over; Astigmatism; Cell Count; Corneal Endothelial Cell Loss; Cross-Sectional Studies; Endothelium, Corneal; Female; Humans; Male; Middle Aged; Pterygium; Retrospective Studies
PubMed: 24858021
DOI: 10.1097/ICO.0000000000000149 -
International Journal of Molecular... Jul 2000Pterygium is a lesion of the corneoscleral limbus which tends to grow in size, often recurs after surgical excision and is associated with exposure to solar light.... (Review)
Review
Pterygium is a lesion of the corneoscleral limbus which tends to grow in size, often recurs after surgical excision and is associated with exposure to solar light. Additionally, a family history is frequently reported. Loss of heterozygosity (LOH), increased P53 expression and the presence of oncogenic viruses, such as human papilloma virus (HPV) and herpes simplex virus (HSV), have been detected in pterygia, supporting the possible neoplastic nature of the lesion. Co-infection by HSV and HPV as well as LOH at some loci have also been correlated with clinical features, such as postoperative recurrence and history of conjunctivitis. A possible model of pterygium formation is proposed, in which genetic predisposition, environmental factors and viral infection(s) participate in a multi-step process. Future research may lead to new ways of pterygium treatment such as anti-viral or gene therapy.
Topics: Animals; Eye Neoplasms; Herpesvirus 1, Human; Humans; Loss of Heterozygosity; Microsatellite Repeats; Papillomaviridae; Pterygium; Sunlight; Tumor Suppressor Protein p53
PubMed: 10851263
DOI: No ID Found -
Management of pterygium with surgery and radiation therapy. The North Florida Pterygium Study Group.International Journal of Radiation... Jan 1994To compare our results in the management of pterygium using a higher total dose with other reported results. (Clinical Trial)
Clinical Trial Comparative Study Review
PURPOSE
To compare our results in the management of pterygium using a higher total dose with other reported results.
METHODS AND MATERIALS
Between 1971 and 1991, 690 patients were treated with complete surgical excision followed by beta irradiation for primary or recurrent pterygium. Of these patients, 129 had two or more areas involving both eyes for a total of 825 lesions treated. Only 17 patients (2%) had temporal lesions with the rest of the patients having nasal pterygia. All patients underwent complete surgical resection of the pterygium before undergoing radiation therapy. One hundred forty-nine patients had undergone previous surgical resection alone but developed recurrence. After surgical excision, all patients were treated with Strontium-90 applicators starting immediately within 24 hr of surgery. Our standard policy was six weekly applications, each delivering a surface dose of 1000 cGy. The total dose delivered was 6000 cGy. Minimum follow-up was 1 year with a median of greater than 8 years.
RESULTS
There were only fourteen recurrences (1.7%) out of a total of 825 lesions treated. Nine of the fourteen patients received suboptimal therapy undergoing less than five applications of Strontium-90. There were no major complications.
CONCLUSION
The combination of surgical excision followed by adequate Strontium-90 applications is highly effective in the management of pterygium. The optimal total dose appears to be in the range of 2000 cGy to 6000 cGy.
Topics: Adult; Aged; Aged, 80 and over; Brachytherapy; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Pterygium; Strontium Radioisotopes
PubMed: 8270429
DOI: 10.1016/0360-3016(94)90146-5