-
Journal Francais D'ophtalmologie May 2018Pterygium surgery is marked by the possibility of recurrences; one of the techniques which results in the least recurrences is conjunctival autograft. Fixation of the... (Clinical Trial)
Clinical Trial
INTRODUCTION
Pterygium surgery is marked by the possibility of recurrences; one of the techniques which results in the least recurrences is conjunctival autograft. Fixation of the conjunctiva had traditionally been accomplished with sutures. In recent years, conjunctival grafting has also been performed with fibrin glue. Even more recently, with a view towards improving the quality of postoperative results, some surgeons recommend the use of autologous blood. This study aims to evaluate the stability of this latest method of graft fixation, while assessing its postoperative results.
METHODOLOGY
After diagnosis of pterygium, the patients underwent pterygium surgery with a conjunctival graft fixated with autologous blood. They were then monitored for one year, at 24h postoperatively, then seven days, 15 days, one month 3months, and every 3months thereafter.
RESULTS
In totl, 84.21 % of the patients demonstrated stable postoperative fixation; 5.26 % of patients experienced significant displacement of the graft. After one year of follow-up, 15.79 % of patients experienced recurrent pterygium. Recurrences were more frequent in younger patients and in patients with previous recurrence.
CONCLUSION
Pterygium surgery by conjunctival graft fixated with autologous blood is a safe surgery, with results similar to other pterygium surgery techniques with conjunctival autograft. However, this technique has the advantage less irritation, no risk of transmitting infection and lower cost.
Topics: Adult; Aged; Autografts; Conjunctiva; Female; Humans; Male; Middle Aged; Ophthalmologic Surgical Procedures; Postoperative Complications; Pterygium; Recurrence; Surgical Wound Dehiscence; Sutureless Surgical Procedures; Transplantation, Autologous; Visual Acuity; Young Adult
PubMed: 29776761
DOI: 10.1016/j.jfo.2017.10.007 -
American Journal of Ophthalmology Feb 1953
Topics: Humans; Ophthalmologic Surgical Procedures; Pterygium
PubMed: 13016756
DOI: No ID Found -
Indian Journal of Ophthalmology Mar 1983
Topics: Adult; Aged; Conjunctival Diseases; Conjunctival Neoplasms; Cysts; Female; Humans; Male; Middle Aged; Pterygium
PubMed: 6662569
DOI: No ID Found -
The British Journal of Ophthalmology May 1962
Topics: Humans; Ophthalmologic Surgical Procedures; Pterygium
PubMed: 18170784
DOI: 10.1136/bjo.46.5.315 -
Indian Journal of Pediatrics 1997Severely involved female child with Multiple Pterygium Syndrome (Escobar) is described. She had the typical findings of the syndrome such as multiple pterygiums,...
Severely involved female child with Multiple Pterygium Syndrome (Escobar) is described. She had the typical findings of the syndrome such as multiple pterygiums, characteristic facial appearance, genital anomalies. She also had bilateral optic atrophy. This is the first case described so far with optic atrophy in Multiple Pterygium Syndrome (Escobar).
Topics: Abnormalities, Multiple; Arm; Atrophy; Child; Consanguinity; Face; Female; Foot Deformities, Congenital; Genitalia, Female; Humans; Optic Nerve; Pterygium; Spine; Syndrome
PubMed: 10771823
DOI: 10.1007/BF02795791 -
Romanian Journal of Morphology and... 2011Pterygium represents an epithelial hyperplasia associated with fibro-vascular growth. It is an active process, associate with cellular proliferation, remodeling of the...
Pterygium represents an epithelial hyperplasia associated with fibro-vascular growth. It is an active process, associate with cellular proliferation, remodeling of the connective tissue, angiogenesis and inflammation. The aim of this study consists of emphasizing angiogenesis involvement in the pterygium pathogeny. The material used for this study consisted of 21 pterygion fragments surgically removed in the Ophthalmology Clinic of the Emergency County Hospital, Craiova. Nine patients were men, 22 were women, and they were aged between 58 and 81 years. Ten fragments of epibulbar conjunctiva from the vicinity of the sclero-corneal limbus were used as control tissue. They were initially histological processed by paraffin inclusion. The immunohistochemical processing was made in the Histological, Histopathological and Immunohistochemical Techniques Laboratory of the University of Medicine and Pharmacy of Craiova. The working technique used was ABC÷HRP (Avidin complexed with biotinylated peroxidase). Angiogenesis in the pterygion was investigated with CD31 marker that allows the identification of the vascular endothelium and the establishment of the vascular microdensity and with VEGF, which allowed the identification of the main source of proangiogenic factors in pterygium. Our study emphasized the existence of a much richer vascularization at the level of the pterygium, compared with the one of the normal conjunctiva. The respective blood vessels were best represented in the subepithelial conjunctive, due to the increased necessities of the proliferating pterygium epithelium. The morphology of the blood vessels is specific for the neoformation vessels, which have a small caliber, are branched and have a rarely visible lumen. The investigation of the vascular microdensity has shown the existence of an intense angiogenesis process at the level of the pterygium and the overexpression of the VEGF, mainly in the proliferating structures of the pterygium, plead for the pathogenic involvement of this growth factor in the development of the pterygium.
Topics: Aged; Aged, 80 and over; Conjunctiva; Female; Humans; Male; Middle Aged; Neovascularization, Pathologic; Pterygium; Vascular Endothelial Growth Factors
PubMed: 21892527
DOI: No ID Found -
Journal Francais D'ophtalmologie Dec 2023To optimize the pterygium management by delineating the role of sutureless, glueless conjunctival graft.
PURPOSE
To optimize the pterygium management by delineating the role of sutureless, glueless conjunctival graft.
MATERIALS AND METHODS
This was a prospective cohort study carried out at the Centre hospitalier universitaire de Cocody between October 1st, 2021 and March 31st, 2022. It analyzed a series of 36 cases of stage I, II and III pterygium by Cornand's classification, who underwent surgery by a sutureless conjunctival graft technique without biological glue.
RESULTS
Demographically, 33.3% of our study population were between 30 and 40 years of age, with a mean of 47.86 years. The patients showed a female preponderance, 53%, with a male:female ratio of 0.89. At the clinical level, 75% of our population presented for ocular redness, 84% had a nasal pterygium, and 75% were stage 2. In terms of postoperative course and appearance, we observed 80.55% graft stability, 5.56% graft retraction, 2.78% graft displacement, and 11.11% graft loss. At the conclusion of follow-up, we noted an 8.33% recurrence rate.
DISCUSSION
The use of intraoperative blood ensures patient safety and postoperative comfort. This technique demonstrates satisfactory results with primary, nasal pterygia.
CONCLUSION
Conjunctival autograft without sutures or biological glue might be a very promising surgical alternative in the surgical treatment of pterygium.
Topics: Humans; Male; Female; Middle Aged; Pterygium; Prospective Studies; Tissue Adhesives; Follow-Up Studies; Suture Techniques; Recurrence; Cote d'Ivoire; Conjunctiva; Transplantation, Autologous; Fibrin Tissue Adhesive; Postoperative Complications
PubMed: 37770319
DOI: 10.1016/j.jfo.2023.03.036 -
Journal of Medical Genetics May 1990
Topics: Diagnosis, Differential; Face; Genitalia; Humans; Incidence; Infant, Newborn; Male; Muscles; Pterygium; Syndrome
PubMed: 2352260
DOI: 10.1136/jmg.27.5.320 -
Turkish Journal of Ophthalmology Dec 2023To determine the roles of small GTP-binding proteins Rac1, Rac2, and Rac3 expression in pterygial tissue and to compare these expressions with normal conjunctival tissue.
OBJECTIVES
To determine the roles of small GTP-binding proteins Rac1, Rac2, and Rac3 expression in pterygial tissue and to compare these expressions with normal conjunctival tissue.
MATERIALS AND METHODS
Seventy-eight patients with primary pterygium were enrolled. Healthy conjunctival graft specimens obtained during pterygium surgery were used as control tissue. The real-time polymerase chain reaction method on the BioMark HD dynamic array system was utilized in genomic mRNA for the gene expression analysis. Protein expressions were analyzed using western blot and immunohistochemical methods.
RESULTS
, and gene expressions in pterygial tissues were not markedly elevated when compared to the control specimens (p>0.05). As a very low level of gene expression was observed, further protein expression analysis was performed for the Rac2 and Rac3 proteins. Western blot and immunohistochemical analysis of Rac2 and Rac3 protein expression revealed no significant differences between pterygial and healthy tissues (p>0.05).
CONCLUSION
This is the first study to identify the contribution of Rac proteins in pterygium. Our results indicate that the small GTP-binding protein Rac may not be involved in pterygium pathogenesis.
Topics: Humans; Pterygium; Conjunctiva; rac GTP-Binding Proteins; Blotting, Western
PubMed: 38014881
DOI: 10.4274/tjo.galenos.2023.93765 -
Indian Journal of Pathology &... 2022p16 is an important tumor suppressor gene and responsible for regulating the cell cycle. Diffuse positivity with p16 in the cervix and head/neck carcinomas can be...
CONTEXT
p16 is an important tumor suppressor gene and responsible for regulating the cell cycle. Diffuse positivity with p16 in the cervix and head/neck carcinomas can be regarded as a surrogate marker of the presence of high-risk human papillomavirus (HPV).
AIM
The aim of our study was to search the existence of p16 expression in pterygium. We also analyzed the association of p16 expression with epithelial dysplasia and HPV expression.
SUBJECTS AND METHODS
The study enrolled 75 cases of pterygium. The conjunctival tissues of 10 patients excised by the strabismus surgery were used as control group. All of the slides were stained with p16 via the immunohistochemical method.
RESULTS
49 (65%) of pterygiums showed low-grade epithelial dysplasia. None of the control groups showed dysplasia. Positive expression of p16 in patient group was significantly higher (P < 0.001). Staining percentage (SP) of p16 was between 0 and 26% in pterygium; mean SP was 5.1%. There was no staining in the control group. A total of 59 (72%) pterygium cases were positive with p16. Appoximately 42 of 49 (85%) cases with dysplasia showed p16 staining. There was a significant relation between dysplasia and positive expression of p16 (P < 0.001).
CONCLUSIONS
P16 is significantly expressed in pterygium and correlated with epithelial dysplasia. Furthermore, the existence of p16 expression suggests that HPV is a possible ethiological factor in pterygium. We think that examination of p16 expression and analysis of HPV DNA in p16 positive cases can help us to understand the etiopathogenesis of the disease better.
Topics: Biomarkers, Tumor; Carcinoma in Situ; Conjunctiva; Cyclin-Dependent Kinase Inhibitor p16; DNA, Viral; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Papillomavirus Infections; Pterygium
PubMed: 35435356
DOI: 10.4103/IJPM.IJPM_1152_20