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Journal of the American Dental... Sep 1970
Topics: Adolescent; Adult; Dental Pulp Exposure; Dental Pulp Test; Female; Humans; Male; Middle Aged; Pain; Pulpitis; Radiography
PubMed: 5271058
DOI: 10.14219/jada.archive.1970.0293 -
Deutsche Stomatologie (Berlin, Germany... 1991Resulting from clinical observation the relations between acute and chronical pulpitis and pulpitis chronica clausa, regressive metamorphoses and pulpal biomorphose are... (Review)
Review
Resulting from clinical observation the relations between acute and chronical pulpitis and pulpitis chronica clausa, regressive metamorphoses and pulpal biomorphose are examined by histological findings and the literature. The etiological, nosological and pathohistological differentiation of this process is discussed. With the rising up of endodontological therapy needs into the middle and higher age the chronical inflammatorical and biomorphological events are more important. Proposals for diagnostics, differentiation and in the role wainting up instead of a early therapy are made.
Topics: Chronic Disease; Dental Caries; Humans; Pulpitis
PubMed: 1816865
DOI: No ID Found -
Neuroimmunomodulation 2021This study investigated the clinical values of miR-27a-3p for pulpitis patients, and its association with TLR4.
INTRODUCTION
This study investigated the clinical values of miR-27a-3p for pulpitis patients, and its association with TLR4.
METHODS
Sixty-six patients with pulpitis and 34 cases without pulpitis were recruited; the pulp tissue and serum samples were collected from each participant. Real-time polymerase chain reaction was used for measurement of gene expression levels. The diagnosis values were assessed by the receiver operating characteristic curve. The target gene of miR-27a-3p was confirmed by the luciferase reporter assay.
RESULTS
MiR-27a-3p was downregulated in both serum and pulp tissue of pulpitis patients. MiR-27a-3p could distinguish pulpitis patients from healthy controls and might be a predictor for the development of irreversible pulpitis. A high level of TLR4 was also detected in both peripheral blood monocytes and pulp tissues from pulpitis patients and showed a negative association with the miR-27a-3p level. TLR4 was a direct target gene of miR-27a-3p.
DISCUSSION/CONCLUSION
MiR-27a-3p might be a promising biomarker for the diagnosis of pulpitis and predict the development of irreversible pulpitis. MiR-27a-3p might be involved in the pathogenesis of pulpitis via targeting TLR4.
Topics: Gene Expression; Humans; MicroRNAs; Pulpitis
PubMed: 34237753
DOI: 10.1159/000516136 -
Nihon Shika Ishikai Zasshi Feb 1967
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Biomolecules May 2023Despite advancements in dental pain management, one of the most common reasons for emergency dental care is orofacial pain. Our study aimed to determine the effects of...
Despite advancements in dental pain management, one of the most common reasons for emergency dental care is orofacial pain. Our study aimed to determine the effects of non-psychoactive constituents in the treatment of dental pain and related inflammation. We tested the therapeutic potential of two non-psychoactive constituents, cannabidiol (CBD) and β-caryophyllene (β-CP), in a rodent model of orofacial pain associated with pulp exposure. Sham or left mandibular molar pulp exposures were performed on Sprague Dawley rats treated with either vehicle, the phytocannabinoid CBD (5 mg/kg i.p.) or the sesquiterpene β-CP (30 mg/kg i.p.) administered 1 h pre-exposure and on days 1, 3, 7, and 10 post-exposure. Orofacial mechanical allodynia was evaluated at baseline and post-pulp exposure. Trigeminal ganglia were harvested for histological evaluation at day 15. Pulp exposure was associated with significant orofacial sensitivity and neuroinflammation in the ipsilateral orofacial region and trigeminal ganglion. β-CP but not CBD produced a significant reduction in orofacial sensitivity. β-CP also significantly reduced the expression of the inflammatory markers AIF and CCL2, while CBD only decreased AIF expression. These data represent the first preclinical evidence that non-psychoactive cannabinoid-based pharmacotherapy may provide a therapeutic benefit for the treatment of orofacial pain associated with pulp exposure.
Topics: Rats; Animals; Pulpitis; Cannabinoids; Rats, Sprague-Dawley; Nociception; Inflammation; Cannabidiol; Cannabis; Facial Pain
PubMed: 37238715
DOI: 10.3390/biom13050846 -
International Endodontic Journal Oct 2023To assess the clinical and radiographic outcome of partial pulpotomy by comparing MTA Angelus and Total Fill BC, as pulpotomy agents, in mature teeth with deep caries... (Randomized Controlled Trial)
Randomized Controlled Trial
Treatment outcome of partial pulpotomy using two different calcium silicate materials in mature permanent teeth with symptoms of irreversible pulpitis: A randomized clinical trial.
AIM
To assess the clinical and radiographic outcome of partial pulpotomy by comparing MTA Angelus and Total Fill BC, as pulpotomy agents, in mature teeth with deep caries and symptoms indicative of irreversible pulpitis.
METHODOLOGY
The study was designed as a parallel-two arm, double-blind, randomized superiority clinical trial registered at www.
CLINICALTRIALS
gov (NCT04870398). Symptomatic mature permanent teeth with deep caries fulfilling the inclusion criteria were randomly treated using either MTA Angelus or Total Fill BC. A partial pulpotomy was performed and following complete haemostasis, the capping material was placed over the remaining pulp tissue and a postoperative periapical radiograph was taken. Clinical and radiographic follow-up evaluation was performed for a median time of 2 years, whereas levels of pain intensity were evaluated preoperatively and for 7 days after intervention using Visual Analogue Scale. For the primary outcome (failure/success of treatment), the Kaplan-Meier survival curves for the capping materials were plotted and a log-rank test for equality of survivor functions was applied. A multivariable random effects Cox Regression model was also applied. For the secondary outcome (postoperatively reported pain), a multivariable mixed effects ordinal logistic regression was structured.
RESULTS
One hundred and thirty-seven teeth in 123 patients underwent partial pulpotomy using randomly either MTA Angelus (N = 74) or Total Fill BC (n = 63). The percentage failure for MTA Angelus and Total Fill BC was 10.8% (8/74) and 17.5% (11/63), respectively, but the difference was not statistically significant [adjusted HR: 1.83; 95% confidence interval (CI): 0.68, 4.91; p = .23]. Weak evidence was found that secondary caries involvement may impose a 3.54 times greater hazard for treatment failure (adjusted HR: 3.54; 95% CI: 1.00, 12.51; p = .05). For each passing minute of procedural bleeding control, there was also a 57% higher hazard for treatment failure (adjusted HR: 1.57; 95% CI: 0.99, 2.48; p = .05). The odds for higher postoperative pain were 4.73 times greater for the Total Fill BC compared to MTA Angelus (adjusted OR: 4.73; 95% CI: 2.31, 9.66; p < .001).
CONCLUSIONS
Both materials exhibited similar and favourable outcome rates after partial pulpotomy in teeth with deep caries and symptoms of irreversible pulpitis. Total Fill BC was associated with a higher level of postoperative pain intensities.
Topics: Humans; Pulpitis; Pulpotomy; Calcium Compounds; Silicates; Oxides; Treatment Outcome; Drug Combinations; Aluminum Compounds
PubMed: 37452640
DOI: 10.1111/iej.13955 -
Oral Surgery, Oral Medicine, and Oral... Jul 1972
Topics: Animals; Dental Amalgam; Dental Caries; Dental Cavity Preparation; Dental Pulp; Disease Models, Animal; Gutta-Percha; Haplorhini; Pulpitis
PubMed: 4624753
DOI: 10.1016/0030-4220(72)90278-2 -
Deutsche Zahn-, Mund-, Und... 1966
Topics: Humans; Pulpitis
PubMed: 5230091
DOI: No ID Found -
Medicina Oral, Patologia Oral Y Cirugia... 2004At present, the majority of the treatments that are performed in the clinic are due to disease entities involving the dental pulp and periapex. Dental pulp is a richly...
At present, the majority of the treatments that are performed in the clinic are due to disease entities involving the dental pulp and periapex. Dental pulp is a richly vascularized and innervated tissue, enclosed by surrounding tissues that are incapable of expanding, such as dentin. It has terminal blood flow and small-gauge circulatory access the periapex. All of these characteristics severely constrain the defensive capacity of the pulp tissue when faced with the different aggressions it may be subjected to. Pulp tissue can also be affected by a retrograde infection, arising from the secondary canaliculi, from the periodontal ligament or from the apex during the course of periodontitis. Due to the fact that periapical disease is almost inevitably preceded by pulp disease, we shall begin by describing the causes of pulp disease and will then proceed to a discussion of the causes of periapical disease. The course of illness and classification of these pathological entities will depend on the aetiology involved. We will analyse pulp necrosis and pulp degeneration that are capable of triggering reversible apical periodontitis or irreversible apical periodontitis.
Topics: Dental Pulp Necrosis; Disease Progression; Humans; Periapical Periodontitis; Pulpitis
PubMed: 15580137
DOI: No ID Found -
Journal of Endodontics Dec 2022Cracked teeth with reversible pulpitis can be managed with orthodontic bands in the interim before definitive restorations. The aim of this study was to determine...
INTRODUCTION
Cracked teeth with reversible pulpitis can be managed with orthodontic bands in the interim before definitive restorations. The aim of this study was to determine short-term outcomes of these teeth following orthodontic band placement. The time taken for definitive pulp diagnoses after orthodontic band placement and associated prognostic factors was also analyzed.
METHODS
One hundred twenty-five patients with a cracked tooth with reversible pulpitis each were recruited. Preoperative data including patient and tooth factors were collected. Cracked teeth were banded and reviewed until symptoms resolved before referral for coronal coverage. Kaplan-Meier and Cox analyses were performed to analyze pulp survival of these teeth. Prognostic factors were investigated using Pearson's chi-square and Student's t-test.
RESULTS
One hundred twenty-two cracked teeth were analyzed. One hundred thirteen (92.6%) teeth had the pulpitis resolved within 2 months (median 40.0; interquartile range 28-61). The median time taken for progression to irreversible pulpitis or pulp necrosis for teeth that required root canal treatment was 3 months (median 90.0; interquartile range 68-110). No prognostic factors were associated with the resolution of pulpal symptoms. However, higher preoperative triggered pain scores (P < .05, hazards ratio 1.547) and absence of a distal marginal ridge crack (P < .05, hazards ratio 0.638) were correlated with a longer duration before definitive pulp diagnoses.
CONCLUSION
Following orthodontic band placement, a normal pulp diagnosis was achieved in 92.6% of cracked teeth with preoperative reversible pulpitis. Definitive pulp diagnoses could be determined in approximately 2 months. Teeth with higher preoperative triggered pain scores may require a longer review period.
Topics: Humans; Pulpitis; Prospective Studies; Cracked Tooth Syndrome; Dental Pulp Necrosis; Pain
PubMed: 36150561
DOI: 10.1016/j.joen.2022.09.002