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Indian Journal of Physiology and... 2007Premenstrual syndrome (PMS) is a universal problem of women of reproductive age group. No satisfactory treatment is available to treat this syndrome till date. Sixty... (Randomized Controlled Trial)
Randomized Controlled Trial
Premenstrual syndrome (PMS) is a universal problem of women of reproductive age group. No satisfactory treatment is available to treat this syndrome till date. Sixty female patients with PMS in age group of 20-45 years were interviewed. A detailed history and 20 premenstrual symptoms were included for making the diagnosis of PMS. Premenstrual symptom score of each patient was recorded before treatment. Patients were followed up monthly for 3 months after starting treatment, to ascertain the change in score. The patients were divided into 3 groups of 20 patients each - control group, bromocriptine group and pyridoxine group. In control group, patients were kept on ferrous sulphate tablet 100 mg for 3 months, as placebo. There was no significant change in the premenstrual symptoms score at the end of the study period in control group. Bromocriptrine 2.5 mg twice a day and pyridoxine 100 mg/day showed a significant reduction in the mean premenstrual symptom score after 3 months of treatment. It is concluded that both the drugs are effective for treatment of premenstrual syndrome but, pyridoxine showed significantly higher response rate and lesser incidence of side effects than bromocriptine.
Topics: Adult; Bromocriptine; Female; Humans; Middle Aged; Premenstrual Syndrome; Pyridoxine
PubMed: 18476391
DOI: No ID Found -
East African Medical Journal Aug 1989Nine Nigerian children, with infantile spasms, 4 boys and 5 girls age 2.5-15 months, were treated with high doses of vitamin B6. Unlike results from some European and...
Nine Nigerian children, with infantile spasms, 4 boys and 5 girls age 2.5-15 months, were treated with high doses of vitamin B6. Unlike results from some European and Japanese centres, our results have not been encouraging. Possible reasons for this poor response are suggested.
Topics: Administration, Oral; Electroencephalography; Female; Humans; Infant; Male; Nigeria; Pyridoxine; Spasms, Infantile
PubMed: 2606037
DOI: No ID Found -
Nutrition Reviews Jan 1981
Review
Topics: Animals; Biological Assay; Biological Availability; Dietary Fiber; Drug Stability; Food; Food Analysis; Food Handling; Humans; Intestinal Absorption; Pyridoxal; Pyridoxal Phosphate; Pyridoxamine; Pyridoxine
PubMed: 6261196
DOI: 10.1111/j.1753-4887.1981.tb06700.x -
Bioorganic & Medicinal Chemistry Jul 2013A series of 13 phosphonium salts on the basis of pyridoxine derivatives were synthesized and their antibacterial activity against clinically relevant strains was tested...
A series of 13 phosphonium salts on the basis of pyridoxine derivatives were synthesized and their antibacterial activity against clinically relevant strains was tested in vitro. All compounds were almost inactive against gram-negative bacteria and exhibited structure-dependent activity against gram-positive bacteria. A crucial role of ketal protection group in phosphonium salts for their antibacterial properties was demonstrated. Among synthesized compounds 5,6-bis[triphenylphosphonio(methyl)]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine dichloride (compound 20) was found to be the most effective towards Staphylococcus aureus and Staphylococcus epidermidis strains (MIC 5μg/ml). The mechanism of antibacterial activity of this compound probably involves cell penetration and interaction with genomic and plasmid DNA.
Topics: Anti-Bacterial Agents; Bacteria; Cells, Cultured; Fibroblasts; Humans; Molecular Structure; Organophosphorus Compounds; Pyridoxine; Skin
PubMed: 23683836
DOI: 10.1016/j.bmc.2013.04.051 -
Journal of Paediatrics and Child Health 2007Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants. Life-long therapy with pyridoxine is required for...
Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants. Life-long therapy with pyridoxine is required for prevention of seizure recurrence and for an optimum intellectual outcome. With the availability of newer biochemical confirmatory tests, the conventional pyridoxine-withdrawal test is being used less frequently for diagnosis. This report describes an infant whose parents were non-compliant with pyridoxine therapy and proposes that pyridoxine-withdrawal test may be useful in demonstrating to parents the need for life-long pyridoxine therapy, thereby reducing non-compliance.
Topics: Humans; India; Infant; Male; Patient Compliance; Pyridoxine; Seizures; Treatment Outcome
PubMed: 17635690
DOI: 10.1111/j.1440-1754.2007.01142.x -
Journal of the American College of... Dec 1995The use of vitamin B6 supplements is widespread today. Doses used are often elevated far above the physiological range and reach levels up to 600-fold higher than... (Comparative Study)
Comparative Study Review
The use of vitamin B6 supplements is widespread today. Doses used are often elevated far above the physiological range and reach levels up to 600-fold higher than recommended dietary allowances for healthy people. While the toxic effects caused by chronic high doses of vitamin B6 have been described earlier, pharmacokinetic data on vitamin B6 supplements are rare. This article reviews the pharmacokinetic data of vitamin B6 from human subjects.
Topics: Aging; Circadian Rhythm; Erythrocytes; Humans; Pyridoxine; Sex Characteristics
PubMed: 8598418
DOI: 10.1080/07315724.1995.10718546 -
Vitamins and Hormones 2001In spite of the rather simple structure of pyridoxal 5'-phosphate (I), a member of the vitamin B6 group, the elucidation of its de novo biosynthesis remained largely... (Review)
Review
In spite of the rather simple structure of pyridoxal 5'-phosphate (I), a member of the vitamin B6 group, the elucidation of its de novo biosynthesis remained largely unexplored until recently. Experiments designed to investigate the formation of the vitamin B6 pyridine nucleus mainly concentrated on Escherichia coli. The results of tracer experiments with radioactive and stable isotopes, feeding experiments, and molecular biological studies led to the prediction that 4-hydroxy-L-threonine (VIII, R = H) and 1-deoxy-D-xylulose (VII, R = H) are precursors which are assembled to yield the carbon-nitrogen skeleton of vitamin B6. At this point, the involvement of the phosphorylated forms of these precursors in this assembly seems quite clear. However, vitamin B6 biosynthesis in organisms other than E. coli remains largely unknown. Toxic derivatives of vitamin B6, such as ginkgotoxin, occurring in higher plants may be suitable targets to gain further insight into this tricky problem.
Topics: Escherichia coli; Ginkgo biloba; Organophosphates; Phosphorylation; Plants, Medicinal; Pyridoxine; Threonine
PubMed: 11153264
DOI: 10.1016/s0083-6729(01)61004-5 -
Seizure May 2024The main objective of this study was to evaluate the neurological consequences of delayed pyridoxine administration in patients diagnosed with Pyridoxin Dependent... (Observational Study)
Observational Study
BACKGROUND
The main objective of this study was to evaluate the neurological consequences of delayed pyridoxine administration in patients diagnosed with Pyridoxin Dependent Epilepsies (PDE).
MATERIALS AND METHODS
We reviewed 29 articles, comprising 52 genetically diagnosed PDE cases, ensuring data homogeneity. Three additional cases were included from the General Pediatric Operative Unit of San Marco Hospital. Data collection considered factors like age at the first seizure's onset, EEG reports, genetic analyses, and more. Based on the response to first-line antiseizure medications, patients were categorized into four distinct groups. Follow-up evaluations employed various scales to ascertain neurological, cognitive, and psychomotor developments.
RESULTS
Our study includes 55 patients (28 males and 27 females), among whom 15 were excluded for the lack of follow-up data. 21 patients were categorized as "Responder with Relapse", 11 as "Resistant", 6 as "Pyridoxine First Approach", and 2 as "Responders". The neurological outcome revealed 37,5 % with no neurological effects, 37,5 % showed complications in two developmental areas, 15 % in one, and 10 % in all areas. The statistical analysis highlighted a positive correlation between the time elapsed from the administration of pyridoxine after the first seizure and worse neurological outcomes. On the other hand, a significant association was found between an extended latency period (that is, the time that elapsed between the onset of the first seizure and its recurrence) and worse neurological outcomes in patients who received an unfavorable score on the neurological evaluation noted in a subsequent follow-up.
CONCLUSIONS
The study highlights the importance of early recognition and intervention in PDE. Existing medical protocols frequently overlook the timely diagnosis of PDE. Immediate administration of pyridoxine, guided by a swift diagnosis in the presence of typical symptoms, might improve long-term neurological outcomes, and further studies should evaluate the outcome of PDE neonates promptly treated with Pyridoxine.
Topics: Humans; Pyridoxine; Epilepsy; Male; Female; Anticonvulsants; Infant, Newborn; Vitamin B Complex; Infant
PubMed: 38735085
DOI: 10.1016/j.seizure.2024.04.012 -
Bioorganic & Medicinal Chemistry Dec 2018Two series of novel pyridoxine-based azaheterocyclic analogs of feruloyl methane (Dehydrozingerone, DZG) were synthesized, and their biological activity against a panel...
Two series of novel pyridoxine-based azaheterocyclic analogs of feruloyl methane (Dehydrozingerone, DZG) were synthesized, and their biological activity against a panel of tumor and normal cell lines was evaluated in vitro. The most active compounds possessed expressed cytotoxic activity, which was comparable to cytotoxic activity of doxorubicin and significantly higher than that of DZG, and a remarkable selectivity for the studied cancer cell lines as compared to the normal cells. The leading compound and DZG initiated arrest of the cell cycle in the G2/M phase, preventing normal division and further transition of daughter cells to the G0/G1 phase. Similar to DZG, but with higher efficiency, the leading compound was able to inhibit migration activity and, therefore, invasiveness of tumor cells. It also increased concentration of reactive oxygen species in tumor cells, induced depolarization of mitochondrial membranes and initiated apoptosis accompanied by disruption of integrity of cytoplasmic cell membranes. By contrast to DZG, the leading compound did not possess antioxidant properties. The obtained data make the described chemotype a promising starting point for the development of new anticancer agents.
Topics: Alkenes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Methane; Models, Molecular; Molecular Structure; Pyridoxine; Structure-Activity Relationship
PubMed: 30429098
DOI: 10.1016/j.bmc.2018.10.031 -
The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III).Food and Chemical Toxicology : An... Mar 1988The effect of vitamin E, folic acid, pyridoxine (vitamin B6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also...
The effect of vitamin E, folic acid, pyridoxine (vitamin B6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour (III) also known as ammonia caramel colour (beer type; AC) has been examined. It was found that the reduction in the number of circulating lymphocytes in rats fed AC could be prevented by the addition of pyridoxine to the diet. The activity of AC in reducing the number of circulating lymphocytes also closely resembled that of the pyridoxine antagonist 4'-deoxypyridoxine. After the isolation and identification of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), comparative studies indicated that THI was the component of AC responsible for reducing the number of circulating lymphocytes. Although the effect of AC was reduced or prevented by increasing dietary pyridoxine, the lymphocyte reduction associated with the administration of THI was not materially affected by the dietary level of pyridoxine.
Topics: Animals; Candy; Carbohydrates; Diet; Food Coloring Agents; Imidazoles; Leukocyte Count; Lymphocytes; Male; Organic Chemicals; Pyridoxine; Rats; Rats, Inbred Strains; Vitamins
PubMed: 3366420
DOI: 10.1016/0278-6915(88)90119-6