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Indian Journal of Medical Sciences 1974
Topics: Adult; Anemia, Sideroblastic; Humans; Male; Pyridoxine
PubMed: 4435927
DOI: No ID Found -
Vitamins and Hormones 1968
Topics: Anemia; Female; Humans; Male; Middle Aged; Pyridoxine
PubMed: 5713372
DOI: 10.1016/s0083-6729(08)60774-8 -
Clinica Chimica Acta; International... Sep 1994The utilization of a usual dose of intravenously infused pyridoxine (100 mg pyridoxine hydrochloride) was investigated in ten healthy males. Blood plasma and...
The utilization of a usual dose of intravenously infused pyridoxine (100 mg pyridoxine hydrochloride) was investigated in ten healthy males. Blood plasma and erythrocytes were investigated by means of high-performance liquid chromatography. Detectable metabolites in blood plasma were pyridoxine, pyridoxal 5'-phosphate, pyridoxal and 4-pyridoxic acid. In erythrocytes pyridoxine, pyridoxal 5'-phosphate, pyridoxal, and pyridoxamine 5'-phosphate were found. From their concentration-time curves rate constants of elimination and invasion, volume of distribution (pyridoxine) and the areas under the curves were calculated. Values for concmax and tmax are reported. A comparison with earlier results of oral pyridoxine administration revealed a better utilization after intravenous than after oral application, i.e. a greater build-up of coenzyme forms. A regulatory phenomenon in erythrocytes caused by high doses of pyridoxine is described. In view of the potential toxicity of pyridoxine the doses used in parenteral nutrition are called into question.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Pyridoxal; Pyridoxal Phosphate; Pyridoxamine; Pyridoxine
PubMed: 7988052
DOI: 10.1016/0009-8981(94)90226-7 -
The Journal of Nutrition Nov 1993Pyridoxine-5'-beta-D-glucoside (PNG), which is abundant in various plant-derived food products, has been shown to be poorly utilized in male rats and adult men. To...
Pyridoxine-5'-beta-D-glucoside (PNG), which is abundant in various plant-derived food products, has been shown to be poorly utilized in male rats and adult men. To assess the metabolic utilization of PNG during pregnancy and the availability to the fetus, [3H]PNG and [14C]pyridoxine (PN) were orally administered to 15-d pregnant rats for direct assessment of the intestinal absorption, tissue distribution, and urinary excretion of the radioisotopes. The level of 3H was significantly greater in the liver, and urinary excretion of 3H tended to be lower than that of 14C. The relative distribution of 3H among the groups of B-6 vitamers within the liver was similar to that for 14C. There was greater uptake by the fetus of 3H than of 14C. There was no difference in the relative concentrations of 3H and 14C among the groups of B-6 vitamers within the fetus. Results of this study suggest that the metabolic utilization of PNG is similar to that of PN during pregnancy. Therefore, the availability of vitamin B-6 derived from maternal PNG seems to be similar to that of vitamin B-6 derived from maternal PN.
Topics: Administration, Oral; Animals; Biological Availability; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Female; Fetus; Glucosides; Intestinal Absorption; Liver; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Pyridoxine; Rats; Tissue Distribution; Tritium
PubMed: 8229303
DOI: 10.1093/jn/123.11.1875 -
Annals of the New York Academy of... Sep 1969
Topics: Cycloserine; Humans; Male; Middle Aged; Neurons; Pyridoxine; Seizures
PubMed: 5262029
DOI: 10.1111/j.1749-6632.1969.tb54286.x -
Biochimica Et Biophysica Acta Aug 1980Evidence, obtained with in situ perfused rat liver, indicated that pyridoxine is taken up from the perfusate by a non-concentrative process, followed by metabolic...
Evidence, obtained with in situ perfused rat liver, indicated that pyridoxine is taken up from the perfusate by a non-concentrative process, followed by metabolic trapping. These conclusions were reached on the basis of the fact that at low concentrations (0.125 microM), the 3H of [3H]pyridoxine accumulated against a concentration gradient, but high concentrations (333 microM) of pyridoxine or 4-deoxypyridoxine prevented this apparent concentrative uptake. Under no conditions did the tissue water:perfusate concentration ratio of [3H]pyridoxine exceed unity. The perfused liver rapidly converted the labeled pyridoxine to pyridoxine phosphate, pyridoxal phosphate and pyridoxamine phosphate and released a substantial amount of pyridoxal and some pyridoxal phosphate into the perfusate. Since muscle and erythrocytes failed to oxidize pyridoxine phosphate to pyridoxal phosphate, it is suggested that the liver plays a major role in oxidizing dietary pyridoxine and pyridoxamine as their phosphate esters to supply pyridoxal phosphate which then reaches to other organs chiefly as circulating pyridoxal.
Topics: Absorption; Animals; Biological Transport; Body Water; Erythrocytes; In Vitro Techniques; Liver; Male; Muscles; Perfusion; Pyridoxine; Rats; Tritium
PubMed: 7397240
DOI: 10.1016/0304-4165(80)90059-8 -
European Journal of Clinical Nutrition Jan 1997
Review
Topics: Animals; Biological Availability; Diet; Food; Humans; Intestinal Absorption; Pyridoxine
PubMed: 9023480
DOI: No ID Found -
The American Journal of Medical... Jan 1983A wealth of information has accumulated over the past several decades with respect to the B-complex vitamins and their roles in health and disease. This paper focuses on... (Review)
Review
A wealth of information has accumulated over the past several decades with respect to the B-complex vitamins and their roles in health and disease. This paper focuses on a member of the B complex, vitamin B6, reviewing its biochemical functions, associated disease states, and laboratory evaluation.
Topics: Adult; Animals; Chemical Phenomena; Chemistry; Child; Female; Humans; Infant; Metabolism, Inborn Errors; Pyridoxal Phosphate; Pyridoxine; Rats; Transaminases; Tryptophan; Vitamin B 6 Deficiency
PubMed: 6342384
DOI: No ID Found -
The New England Journal of Medicine Apr 1985We measured urinary oxalate and glycolate excretion before and during pyridoxine administration (2 to 200 mg per day) in four patients with primary hyperoxaluria. In two...
We measured urinary oxalate and glycolate excretion before and during pyridoxine administration (2 to 200 mg per day) in four patients with primary hyperoxaluria. In two patients with type I primary hyperoxaluria, urinary oxalate and glycolate excretion fell markedly in response to a physiologic dose of pyridoxine of 2 mg per day and became completely normal when the dose was increased to 25 mg per day. In the other two patients, who had a different type of primary hyperoxaluria (normal urinary glycolate excretion), there was no response to 2 mg of pyridoxine per day. In one of these patients, doses of 25 and 50 mg per day were also ineffective, but a moderate reduction in oxalate excretion took place with 200 mg per day; in the other patient there was a moderate reduction in oxalate excretion with 25 mg of pyridoxine per day. Our findings suggest that the degree of hyperoxaluria in this disorder may be only slight or moderate if the patient has been ingesting a pyridoxine-rich diet or multivitamin tablets containing small amounts of pyridoxine. Our results also suggest that smaller doses of pyridoxine than those heretofore employed should be tried in patients with primary hyperoxaluria.
Topics: Child; Female; Glycolates; Humans; Kidney Calculi; Metabolism, Inborn Errors; Oxalates; Oxalic Acid; Pyridoxine
PubMed: 3974685
DOI: 10.1056/NEJM198504113121504 -
Annals of the New York Academy of... 1990
Review
Topics: Abnormalities, Drug-Induced; Animals; Humans; Nervous System Diseases; Pyridoxine
PubMed: 2192616
DOI: 10.1111/j.1749-6632.1990.tb28064.x