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The Journal of Pediatrics Jan 2023Acute kidney injury occurs frequently during pediatric diabetic ketoacidosis (DKA). We reviewed urinalyses from 561 children with DKA; pyuria was detected in 19% overall... (Review)
Review
Acute kidney injury occurs frequently during pediatric diabetic ketoacidosis (DKA). We reviewed urinalyses from 561 children with DKA; pyuria was detected in 19% overall and in 40% of children with more comprehensive urine testing (≥3 urinalyses) during DKA.
Topics: Child; Humans; Diabetic Ketoacidosis; Pyuria; Diabetes Mellitus, Type 1; Acute Kidney Injury
PubMed: 36084731
DOI: 10.1016/j.jpeds.2022.08.054 -
Clinical Infectious Diseases : An... Jun 2023Pre-existing lower urinary tract symptoms (LUTS), cognitive impairment, and the high prevalence of asymptomatic bacteriuria (ASB) complicate the diagnosis of urinary...
BACKGROUND
Pre-existing lower urinary tract symptoms (LUTS), cognitive impairment, and the high prevalence of asymptomatic bacteriuria (ASB) complicate the diagnosis of urinary tract infection (UTI) in older women. The presence of pyuria remains the cornerstone of UTI diagnosis. However, >90% of ASB patients have pyuria, prompting unnecessary treatment. We quantified pyuria by automated microscopy and flowcytometry to determine the diagnostic accuracy for UTI and to derive pyuria thresholds for UTI in older women.
METHODS
Women ≥65 years with ≥2 new-onset LUTS and 1 uropathogen ≥104 colony-forming units (CFU)/mL were included in the UTI group. Controls were asymptomatic and classified as ASB (1 uropathogen ≥105 CFU/mL), negative culture, or mixed flora. Patients with an indwelling catheter or antimicrobial pretreatment were excluded. Leukocyte medians were compared and sensitivity-specificity pairs were derived from a receiver operating characteristic curve.
RESULTS
We included 164 participants. UTI patients had higher median urinary leukocytes compared with control patients (microscopy: 900 vs 26 leukocytes/µL; flowcytometry: 1575 vs 23 leukocytes/µL; P < .001). Area under the curve was 0.93 for both methods. At a cutoff of 264 leukocytes/µL, sensitivity and specificity of microscopy were 88% (positive and negative likelihood ratio: 7.2 and 0.1, respectively). The commonly used cutoff of 10 leukocytes/µL had a poor specificity (36%) and a sensitivity of 100%.
CONCLUSIONS
The degree of pyuria can help to distinguish UTI in older women from ASB and asymptomatic controls with pyuria. Current pyuria cutoffs are too low and promote inappropriate UTI diagnosis in older women. Clinical Trials Registration. International Clinical Trials Registry Platform: NL9477 (https://trialsearch.who.int/Trial2.aspx?TrialID=NL9477).
Topics: Humans; Female; Aged; Pyuria; Urinary Tract Infections; Bacteriuria; Sensitivity and Specificity; ROC Curve
PubMed: 36806580
DOI: 10.1093/cid/ciad099 -
The American Journal of Medicine Jul 1983Excluding specimen contamination, bacteriuria indicates either urinary colonization (replication of bacteria in urine without evidence of tissue invasion) or urinary... (Review)
Review
Excluding specimen contamination, bacteriuria indicates either urinary colonization (replication of bacteria in urine without evidence of tissue invasion) or urinary tract infection (bacteriuria associated with clinical, histologic, or immunologic evidence of host injury). Practically speaking, measuring pyuria is the most readily available means of establishing the presence of host injury, thus differentiating colonization from infection. Careful studies have established the nonpathologic limits for pyuria (less than 10 leukocytes/mm3 in uncentrifuged urine) and have compared methods for its measurement. The most commonly used method, determination of cells per high power field in centrifuged urine, is not reproducible and does not correlate with either the actual leukocyte excretion rate or the cells per cubic millimeter as enumerated in a counting chamber. When clinical studies using the latter method of determining pyuria were reviewed, the following conclusions emerged: (1) 10 leukocytes/mm3 or greater occur in less than 1 percent of asymptomatic, nonbacteriuric patients but in greater than 96 percent of symptomatic men and women with significant bacteriuria; (2) most symptomatic women with pyuria but without significant bacteriuria have urinary infection either with bacterial uropathogens present in colony counts less than 10(5)/ml or with Chlamydia trachomatis; (3) women with asymptomatic bacteriuria probably should be divided into two subgroups: those with true asymptomatic infection (associated with pyuria) and those with transient, self-limited bladder colonization; and (4) most patients with catheter-associated bacteriuria also have pyuria and hence infection. In view of its potential value to both clinicians and microbiologists, pyuria should be accurately determined and expressed as cells per cubic millimeter in uncentrifuged urine.
Topics: Bacteria; Bacteriuria; Escherichia coli; Female; Humans; Male; Pyuria; Specimen Handling; Urinary Bladder; Urinary Catheterization; Urinary Tract Infections
PubMed: 6349345
DOI: 10.1016/0002-9343(83)90073-6 -
Annals of Emergency Medicine Oct 2022
Topics: Fever; Humans; Male; Pyuria; Urinary Tract Infections
PubMed: 36153059
DOI: 10.1016/j.annemergmed.2022.05.033 -
The New England Journal of Medicine Jun 2015
Topics: Female; Humans; Infections; Male; Pyuria; Sexually Transmitted Diseases; Urine
PubMed: 26061856
DOI: 10.1056/NEJMc1504516 -
The New England Journal of Medicine Jun 2015
Topics: Female; Humans; Infections; Male; Pyuria; Sexually Transmitted Diseases; Urine
PubMed: 26061857
DOI: 10.1056/NEJMc1504516 -
The New England Journal of Medicine Jun 2015
Topics: Female; Humans; Infections; Male; Pyuria; Sexually Transmitted Diseases; Urine
PubMed: 26061855
DOI: 10.1056/NEJMc1504516 -
The American Journal of Medicine Sep 2022Pyuria is often used as an import marker in the diagnosis of urinary tract infection. The interpretation of pyuria may be especially important in patients with...
BACKGROUND
Pyuria is often used as an import marker in the diagnosis of urinary tract infection. The interpretation of pyuria may be especially important in patients with nonspecific complaints. There is a paucity of data to demonstrate the utility of pyuria alone in the diagnosis of bacteriuria or urinary tract infection. This study aims to further define the relationship of pyuria and positive bacterial growth in urine culture, as well as the diagnostic utility of different urine white blood cell cutoff points.
METHOD
A total of 46,127 patients older than the age of 18 were selected from the inpatient population of HCA Healthcare System Capital Division. Urine microscopy results were stratified by white blood cell count and correlated with positivity of urine culture bacterial growth. The optimal urine white blood cell cutoff was derived based on the receiver operating characteristic curve plot.
RESULTS
Urine microscopy finding of white blood cell 0-5 cell/hpf, 5-10 cell/hpf, 10-25 cell/hpf, and higher than 25 cell/hpf was associated with 25.4%, 28.2%, 33%, and 53.8% rates of bacteriuria, respectively. The receiver operating characteristic curve plot demonstrated that pyuria alone did not provide adequate diagnostic accuracy to predict bacteriuria. The optimal cutoff point for the best combination of sensitivity and specificity was found to be 25 cell/hpf.
CONCLUSION
Pyuria alone provides inadequate diagnostic accuracy for predicting bacteriuria. Urine white blood cell count greater than 25 cell/hpf was found to be the optimal cutoff to detect bacteriuria. The result of this study supports the current guideline recommendation against antibiotic treatment based on urine analysis alone. It also informs future design of randomized controlled trial that investigates interventional strategies for patients with pyuria and nonspecific complaints.
Topics: Bacteriuria; Humans; Microscopy; Pyuria; Urinalysis; Urinary Tract Infections
PubMed: 35580716
DOI: 10.1016/j.amjmed.2022.04.022 -
Comprehensive Therapy 2000Sterile pyuria is not an uncommon laboratory finding. This article explores the major causes of sterile pyuria, including infectious, systemic, structural and... (Review)
Review
Sterile pyuria is not an uncommon laboratory finding. This article explores the major causes of sterile pyuria, including infectious, systemic, structural and physiologic, and drug-related causes. It also discusses the differential diagnosis of eosinophiluria and the basic workup of sterile pyuria.
Topics: Diagnosis, Differential; Humans; Pyuria
PubMed: 10984817
DOI: 10.1007/s12019-000-0001-1 -
Clinical Infectious Diseases : An... Apr 2021Asymptomatic bacteriuria and pyuria in healthy women often trigger inappropriate antimicrobial treatment, but there is a paucity of data on their prevalence and... (Observational Study)
Observational Study
BACKGROUND
Asymptomatic bacteriuria and pyuria in healthy women often trigger inappropriate antimicrobial treatment, but there is a paucity of data on their prevalence and persistence.
METHODS
To evaluate the prevalence and persistence of asymptomatic bacteriuria and pyuria in women at high risk of recurrent urinary tract infection, we conducted an observational cohort study in 104 healthy premenopausal women with a history of recurrent urinary tract infection with daily assessments of bacteriuria, pyuria, and urinary symptoms over a 3-month period.
RESULTS
The mean age of participants was 22 years, and 74% were white. Asymptomatic bacteriuria events (urine cultures with colony count ≥105 CFU/mL of a uropathogen on days with no symptomatic urinary tract infection diagnosed) occurred in 45 (45%) women on 159 (2.5%) of 6283 days. Asymptomatic bacteriuria events were most commonly caused by Escherichia coli, which was present on 1.4% of days, with a median duration of 1 day (range, 1-10). Pyuria occurred in 70 (78%) of 90 evaluable participants on at least 1 day and 25% of all days on which no symptomatic urinary tract infection was diagnosed. The positive predictive value of pyuria for E. coli asymptomatic bacteriuria was 4%.
CONCLUSIONS
In this population of healthy women at high risk of recurrent urinary tract infection, asymptomatic bacteriuria is uncommon and, when present, rarely lasts more than 2 days. Pyuria, on the other hand, is common but infrequently associated with bacteriuria or symptoms. These data strongly support recommendations not to screen for or treat asymptomatic bacteriuria or pyuria in healthy, nonpregnant women.
Topics: Adult; Bacteriuria; Escherichia coli; Female; Humans; Pyuria; Urinalysis; Urinary Tract Infections; Young Adult
PubMed: 32179902
DOI: 10.1093/cid/ciaa274