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Journal of the European Academy of... Feb 2020
Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Humans; Male; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Radiodermatitis
PubMed: 31660660
DOI: 10.1111/jdv.16033 -
Cutis Jun 2020
Topics: Aged; Female; Glucocorticoids; Humans; Prednisone; Radiodermatitis
PubMed: 32716998
DOI: No ID Found -
American Journal of Clinical Dermatology Jun 2016Radiodermatitis (radiation dermatitis, radiation-induced skin reactions, or radiation injury) is a significant side effect of ionizing radiation delivered to the skin... (Review)
Review
Radiodermatitis (radiation dermatitis, radiation-induced skin reactions, or radiation injury) is a significant side effect of ionizing radiation delivered to the skin during cancer treatment as well as a result of nuclear attacks and disasters, such as that which occurred in Fukushima in 2011. More specifically, 95 % of cancer patients receiving radiation therapy will develop some form of radiodermatitis, including erythema, dry desquamation, and moist desquamation. These radiation skin reactions result in a myriad of complications, including delays in treatment, diminished aesthetic appeal, and reduced quality of life. Recent technological advancements and novel treatment regimens have only been successful in partly ameliorating these adverse side effects. This article examines the current knowledge surrounding the pathogenesis, clinical manifestations, differential diagnoses, prevention, and management of radiodermatitis. Future research should examine therapies that incorporate the current understanding of the pathophysiology of radiodermatitis while measuring effectiveness using objective and universal outcome measures.
Topics: Dermatitis, Contact; Diagnosis, Differential; Erythema Multiforme; Humans; Neoplasms; Quality of Life; Radiodermatitis; Radiotherapy; Randomized Controlled Trials as Topic; Risk Factors; Self Care; Severity of Illness Index; Skin; Tinea
PubMed: 27021652
DOI: 10.1007/s40257-016-0186-4 -
Radiotherapy and Oncology : Journal of... Jun 2001Radiation recall represents the 'recalling' of an effect similar in appearance to that of an acute radiation reaction in a previously irradiated field. The recall is... (Review)
Review
Radiation recall represents the 'recalling' of an effect similar in appearance to that of an acute radiation reaction in a previously irradiated field. The recall is triggered by the administration of certain drugs days to years after the exposure to ionizing radiation. This review focuses almost exclusively on the skin manifestations of radiation recall to assemble the largest data base upon which to discuss this rare phenomenon. No absolute radiation dose threshold is apparent, but rather an interplay between dose and time before drug exposure seems to affect both the risk and speed of onset of recall. Recall usually occurs on first exposure to a particular recall-triggering drug. The skin reaction develops within minutes to days. The time to develop the reaction may be slightly longer for oral than intravenously administered drugs reflecting their bioavailability. Most drugs associated with recall are cytotoxics, but several other drugs may elicit the phenomenon. Individuals exposed to a number of potentially recall-triggering drugs reveal the marked drug specificity characteristic of the phenomenon. Skin reactions usually settle within a few days of stopping the triggering drug. The role of steroids or anti-histamines in affecting resolution is unclear. Drug rechallenge tends to produce either only a mild recurrence or no recurrence of recall. Steroids or dose reduction may favour uneventful rechallenge. A number of aetiological hypotheses on radiation recall exist. Using the available evidence these hypotheses are critically reviewed and a novel hypothesis based on radiation affecting local cutaneous immunological responses proposed.
Topics: Humans; Incidence; Radiodermatitis; Radiotherapy; Time Factors
PubMed: 11369064
DOI: 10.1016/s0167-8140(01)00328-0 -
The Breast Journal Jun 2021Radiation recall dermatitis is an inflammatory reaction of the skin, which occurs at previously irradiated areas, usually following a subsequent exposure to an...
Radiation recall dermatitis is an inflammatory reaction of the skin, which occurs at previously irradiated areas, usually following a subsequent exposure to an aggravating factor. Recall dermatitis can occur weeks to months after radiation, and the longest duration between radiation and dermatitis has been reported to be about 25 years. Here, we report a case of recurrent radiation recall dermatitis that developed spontaneously after 40 years following radiation for breast cancer. This case suggests that radiation recall dermatitis can occur much later than previously reported. In spite of this late presentation, topical anti-inflammatory agents managed the condition well.
Topics: Breast Neoplasms; Female; Humans; Radiodermatitis
PubMed: 33763948
DOI: 10.1111/tbj.14212 -
CMAJ : Canadian Medical Association... Feb 2010
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Dermatitis; Female; Humans; Radiodermatitis; Radionuclide Imaging
PubMed: 20026631
DOI: 10.1503/cmaj.090320 -
Practical Radiation Oncology 2021A case is descibed of radiation recall dermatitis in a patient treated with adjuvant radiation therapy followed by capecitabine for triple negative breast cancer with...
A case is descibed of radiation recall dermatitis in a patient treated with adjuvant radiation therapy followed by capecitabine for triple negative breast cancer with residual disease after neoadjuvant chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Female; Humans; Neoadjuvant Therapy; Neoplasm, Residual; Radiodermatitis; Triple Negative Breast Neoplasms
PubMed: 34157449
DOI: 10.1016/j.prro.2021.06.001 -
Annales de Dermatologie Et de... May 2019Radiation recall dermatitis is an uncommon inflammatory reaction of the skin appearing after several days to several years at the site of previous irradiation; it is...
INTRODUCTION
Radiation recall dermatitis is an uncommon inflammatory reaction of the skin appearing after several days to several years at the site of previous irradiation; it is precipitated by the use of triggering drugs, although rarely by BRAF or MEK inhibitors.
PATIENTS AND METHODS
We report an unusual case of recall dermatitis induced 3 months after initiation of vemurafenib and cobimetinib therapy.
DISCUSSION
Radiation recall dermatitis is a cutaneous reaction that must be known and which in rare cases such as ours may occur a long time after the end of radiotherapy.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Azetidines; Ear Auricle; Ear Neoplasms; Facial Dermatoses; Humans; MAP Kinase Kinase 1; Male; Melanoma; Middle Aged; Piperidines; Radiodermatitis; Skin Neoplasms; Vemurafenib
PubMed: 30981540
DOI: 10.1016/j.annder.2018.02.020 -
Annals of Oncology : Official Journal... Sep 1996
Review
Topics: Breast Neoplasms; Female; Humans; Middle Aged; Paclitaxel; Radiation-Sensitizing Agents; Radiodermatitis
PubMed: 8905038
DOI: 10.1093/oxfordjournals.annonc.a010730 -
Hematology/oncology and Stem Cell... Dec 2021
Review
Topics: Aminopyridines; Humans; Purines; Radiodermatitis
PubMed: 32413416
DOI: 10.1016/j.hemonc.2020.04.005