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Biochemical Clinics 1963
Review
Topics: Acid-Base Equilibrium; Acids; Alkalosis; Ammonium Compounds; Bicarbonates; Carbon Dioxide; Hydrogen-Ion Concentration; Kidney; Metabolism; Physiology; Potassium; Quaternary Ammonium Compounds; Respiration; Urine
PubMed: 14095790
DOI: No ID Found -
The American Journal of Physiology Jun 1999The white rat offers a valuable teaching model to demonstrate the in situ anatomy, homeostatic control, and function of the mammalian renal system. Students in the...
The white rat offers a valuable teaching model to demonstrate the in situ anatomy, homeostatic control, and function of the mammalian renal system. Students in the upper-level physiology class at Dickinson College are responsible for formulating a set of testable hypotheses as to the possible compensatory mechanisms that will result from a unilateral nephrectomy in the rat. To test their hypotheses, each group of students is made responsible for induction and maintenance of anesthesia, removal of the left kidney, closure, and recovery of the animal in their experiment. Before and 1 wk after nephrectomy, blood samples are collected via tail section for measurement of hematocrit and plasma creatinine concentrations. Pooling data across all student groups (n = 6) for pre- and postnephrectomy hematocrit and creatinine values allows students to run statistical comparisons testing their hypotheses. This laboratory experience in integrative physiology is a successful exercise in introducing fundamentals of experimental design and, most importantly, provides students with an appreciation for the process of humane use of animals in research and teaching.
Topics: Animals; Education, Medical, Undergraduate; Kidney; Male; Models, Animal; Nephrectomy; Physiology; Rats
PubMed: 16211671
DOI: 10.1152/advances.1999.276.6.S79 -
American Journal of Physiology. Renal... Jul 2007
Topics: Kidney; Physiology
PubMed: 17459955
DOI: 10.1152/ajprenal.00189.2007 -
American Journal of Physiology. Renal... Nov 2004This essay looks at the historical significance of five APS classic papers that are freely available online: Wearn JT and Richards AN. Observations on the composition of...
This essay looks at the historical significance of five APS classic papers that are freely available online: Wearn JT and Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in the renal tubules. Am J Physiol 71: 209-227, 1924 (http://ajplegacy.physiology.org/cgi/reprint/71/1/209). Richards AN and Walker AM. Methods of collecting fluid from known regions of the renal tubules of Amphibia and of perfusing the lumen of a single tubule. Am J Physiol 118: 111-120, 1936 (http://ajplegacy.physiology.org/cgi/reprint/118/1/111). Walker AM and Hudson CL. The reabsorption of glucose from the renal tubule in Amphibia and the action of phlorhizin upon it. Am J Physiol 118: 130-143, 1936 (http://ajplegacy.physiology.org/cgi/reprint/118/1/130). Walker AM and Oliver J. Methods for the collection of fluid from single glomeruli and tubules of the mammalian kidney. Am J Physiol 134: 562-579, 1941 (http://ajplegacy.physiology.org/cgi/reprint/134/3/562). Walker AM, Bott PA, Oliver J, and MacDowell MC. The collection and analysis of fluid from single nephrons of the mammalian kidney. Am J Physiol 134: 580-595, 1941 (http://ajplegacy.physiology.org/cgi/reprint/134/3/580).
Topics: Absorption; Animals; Dogs; Glomerular Filtration Rate; Glucose; Glycosuria; History, 20th Century; Kidney Glomerulus; Kidney Tubules; Physiology
PubMed: 15475539
DOI: 10.1152/classicessays.00019.2004 -
Advances in Physiology Education Dec 2019
Topics: Adrenergic Neurons; Angiotensin II; Comprehension; Curriculum; Glomerular Filtration Rate; Humans; Kidney; Models, Anatomic; Models, Cardiovascular; Physiology; Renal Circulation; Renin-Angiotensin System; Sympathetic Nervous System; Teaching
PubMed: 31642704
DOI: 10.1152/advan.00080.2018 -
The American Journal of Physiology Dec 1998
Review
Topics: Acid-Base Equilibrium; Education, Continuing; Humans; Kidney; Physiology; Teaching; Water-Electrolyte Balance
PubMed: 16161233
DOI: 10.1152/advances.1998.275.6.S114 -
American Journal of Physiology. Renal... Apr 2019
Topics: Cardiovascular Physiological Phenomena; Female; Humans; Kidney; Leadership; Male; Metabolism; Physiology; Sex Characteristics; Societies, Scientific; United States
PubMed: 30759024
DOI: 10.1152/ajprenal.00019.2019 -
Advances in Physiology Education Dec 2004Renal clearance is one of the more difficult concepts for students of physiology to learn. We hypothesized that this difficulty is rooted in a student's misunderstanding... (Review)
Review
Renal clearance is one of the more difficult concepts for students of physiology to learn. We hypothesized that this difficulty is rooted in a student's misunderstanding of virtual volume. This was tested by having students select from several drawings the one they thought plasma would look like after a certain volume of it has been cleared of sodium by the kidneys. About half the participating students selected plasma pictured as having a certain volume of it devoid of sodium molecules. That is, their misconception of clearance seemed to be due to a lack of understanding about virtual volume, a deficiency which is reinforced by the classic definition of clearance. To address this misconception, a demonstration was devised in which a beaker of concentrated colored water was used to represent plasma before renal clearance, a beaker of the same concentrated colored water in which the top third had been replaced by clear mineral oil was used to represent what the definition of clearance said would happen to plasma after a third of it had been cleared of sodium, and a beaker of dilute colored water was used to represent what really happens to plasma when a certain volume of it is cleared of a solute. Incorporating this demonstration into discussions of renal clearance helped students to understand this concept, as evidenced by improved scores on related questions.
Topics: Humans; Kidney; Models, Anatomic; Nephrology; Physiology; Sodium
PubMed: 15545350
DOI: 10.1152/advan.00021.2004 -
Physiological Genomics Jan 2004
Topics: Animals; Cardiovascular Diseases; Gene Expression Profiling; Genomics; Humans; Kidney Diseases; Oligonucleotide Array Sequence Analysis; Physiology
PubMed: 14726600
DOI: 10.1152/physiolgenomics.00195.2003 -
Pediatric Clinics of North America Aug 1964
Topics: Adolescent; Angiography; Angiotensins; Biopsy; Blood Pressure Determination; Child; Diagnosis; Humans; Hypertension; Hypertension, Renal; Infant; Kidney; Kidney Diseases; Kidney Function Tests; Pathology; Physiology; Regional Blood Flow; Renin
PubMed: 14328546
DOI: 10.1016/s0031-3955(16)31591-7